(3E,5E)-3,5-Bis(4-hy­droxy-3,5-di­methoxy­benzyl­idene)oxan-4-one monohydrate

In the title compound, C23H24O8·H2O, the six-membered ring of the oxan-4-one (tetra­hydro­pyran-4-one) ring displays an envelope conformation with the heterocyclic O atom at the flap position. The dihedral angles between the terminal benzene rings is 37.23 (10)°. Classical intermolecular O—H⋯O and weak C—H⋯O hydrogen bonds are present in the crystal structure

The Silencing of RECK Gene is Associated with Promoter Hypermethylation and Poor Survival in Hepatocellular Carcinoma

Background: To evaluate the promoter methylation status of RECK gene and mRNA expression in patients with hepatocellular carcinoma (HCC)

Erzhi Pill® Repairs Experimental Liver Injury via TSC/mTOR Signaling Pathway Inhibiting Excessive Apoptosis

The present study aimed to investigate the mechanism of hepatoprotective effect of Erzhi Pill (EZP) on the liver injury via observing TSC/mTOR signaling pathway activation. The experimental liver injury was induced by 2-acetylaminofluorene (2-AAF) treatment combined with partial hepatectomy (PH). EZP treated 2-AAF/PH-induced liver injury by the therapeutic and prophylactic administration. After the administration of EZP, the activities of aspartic transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AKP), and gamma-glutamyl transpeptidase (γ-GT) were decreased, followed by the decreased levels of hepatocyte apoptosis and caspase-3 expression. However, the secretion of albumin, liver weight, and index of liver weight were elevated. Microscopic examination showed that EZP restored pathological liver injury. Meanwhile, Rheb and mammalian target of rapamycin (mTOR) activation were suppressed, and tuberous sclerosis complex (TSC) expression was elevated in liver tissues induced by 2-AAF/PHx and accompanied with lower-expression of Bax, Notch1, p70S6K, and 4E-EIF and upregulated levels of Bcl-2 and Cyclin D. Hepatoprotective effect of EZP was possibly realized via inhibiting TSC/mTOR signaling pathway to suppress excessive apoptosis of hepatocyte

Examining resilience in local adaptation policies – pilot studies in Taipei and Tainan, Taiwan

Resilience has gained considerable attention over recent years in both theories and decision-making practices. In Taiwan, the term resilience is generally considered as a synonym for adaptation. This may limit the use of the notion. By understanding resilience in terms of adaptation and mitigation, we identify six attributes for assessment. The assessment is addressed in local level climate change adaptation policies in two selected cities. The city of Taipei represents places where local adaptation policies were directed mainly by the national government. The city of Tainan represents places where the municipal government plays a more critical role in framing these policies. This can result in different policymaking considerations. The assessment points out that the proposed actions of these policies are broader than a general understanding of adaptation. Mitigation strategies are addressed and sometimes highly recommended. Because of this, we can interpret these actions as resilience strategies covered under the use of the term adaptation. The notion of resilience does not stay on the rhetorical level alone. It is happening in shaping decisions – without using the terminology directly. The broadness of the resilience notion, in spite of being abstract, can provide a more general framework for cross-sectorial discussion and collaboration in policy-making. This is particularly important for dealing with complex issues, such as climate-related disturbances, which cannot be managed by a single group of professions

Active Transport and Health Outcomes: Findings from a Population Study in Jiangsu, China

To investigate the prevalence of active transport (AT, defined as walking or bicycling for transport) and to explore the association between AT and health outcomes, we conducted a population-based cross-sectional study in Jiangsu, China, where walking and bicycling are still the main modes of transport. In this study, 8400 community residents aged 18 or above were interviewed following a multistage random sampling method (100% response rate). Face-to-face questionnaire survey data, anthropometric measurements, and biochemical data from blood tests were collected. Results show that 49.6% of the subjects, as part of daily transport, actively traveled on average 5.3 days per week, 53.5 minutes per day, and 300.3 minutes per week. There was an inverse correlation between AT and some health outcomes: AT respondents had a higher prevalence of cholesterol disorder; AT respondents who actively travelled every day had a higher risk of diabetes, whilst AT respondents with shorter daily or weekly duration had a lower risk of obesity, central obesity, and cholesterol disorder. Moreover, AT influences more health aspects among urban residents than among rural residents. Findings of this study do not support the notion that AT is beneficial to population health. Further research is needed in determining the negative side effects of AT