1 research outputs found
Siderophore Conjugates of Daptomycin are Potent Inhibitors of Carbapenem Resistant Strains of <i>Acinetobacter baumannii</i>
Development
of resistance to antibiotics is a major medical problem. One approach
to extending the utility of our limited antibiotic arsenal is to repurpose
antibiotics by altering their bacterial selectivity. Many antibiotics
that are used to treat infections caused by Gram-positive bacteria
might be made effective against Gram-negative bacterial infections,
if they could circumvent permeability barriers and antibiotic deactivation
processes associated with Gram-negative bacteria. Herein, we report
that covalent attachment of the normally Gram-positive-only antibiotic,
daptomycin, with iron sequestering siderophore mimetics that are recognized
by Gram-negative bacteria, provides conjugates that are active against
virulent strains of <i>Acinetobacter baumannii</i>, including
carbapenemase and cephalosporinase producers. The result is the generation
of a new set of antibiotics designed to target bacterial infections
that have been designated as being of dire concern