1 research outputs found
Transition-Metal-Free C(sp<sup>3</sup>)–H Hydroxylation of 2‑Oxindoles with Peroxides via Radical Cross-Coupling Reaction in Water
Without
employing any transition metal, organic solvent or other
additive, a novel, economical, and environmentally attractive strategy
has been described for the CÂ(sp<sup>3</sup>)–H hydroxylation
of 2-oxindoles with peroxides via radical cross-coupling reaction
exposed to air in water. This transformation features a wide substrate
scope, operational simplicity, and mild reaction conditions, thus
offering a concise approach to various 3-hydroxy-2-oxindoles. In addition,
a radical pathway was involved in this hydroxylation through mechanistic
studies