Failure Mode And Reliability Analysis Of Frame Structure

In reliability analysis, the correlation between the primary failure mode of a frame structure and other failure modes is very complicated. At present, there are a number of issues associated with the implementation of reliability analysis, including the complex calculation procedure, the low calculation efficiency, and the difficulty in identifying the primary failure mode, etc. Following the framework of reliability analysis for hybrid systems, the reliability of a two-story frame structure is investigated. The internal force distribution in all structural members is analyzed using the numerical method of Finite Element Method (FEM). The critical structural element is calculated, which can help to evaluate the primary failure mode of the frame structure. Once local failure occurs, the internal force redistributes in the system. The pattern of progressive failure of frame structure is then analyzed. The developed numerical model can provide the real-time performance for the structure, which is further employed to conduct reliability analysis. This study demonstrates that the reliability analysis method for hybrid system can reflect the true performance of the structure more realistically.The present work is partially supported by the National Natural Science Foundation of China (Grant Nos. 51204029, 51474050, 51874076 and U1602232) which are gratefully appreciated

The Poverty Alleviation and Immigration Practice Model Effect Research in Liulin

Abstract By the way of field investigation and statistical analysis, I have carried on investigation to Liulin, migrant village and I have learnt something about migration forms, mainly interaction patterns of villages and towns aggregation model. This article mainly analyzes the work and the necessity of immigration for poverty alleviation and the actual effect of the two modes in Lilulin. Moreover, I put forward some suggestions to model improvement and hope that I can do some useful things to poverty reduction in Liulin. At the same time, it can provide favorable help for building a harmonious society

Inherited Wolff–Parkinson–White Syndrome

Wolff–Parkinson–White (WPW) syndrome is a congenital disorder of cardiac conduction system characterized by electrocardiographic preexcitation and episodes of paroxysmal supraventricular tachycardia. It is caused by a cardiac developmental defect in the electrical insulation between the atria and the ventricles due to the presence of an accessory pathway. WPW syndrome is a common cause of supraventricular tachycardia with benign prognosis. However, this clinical entity also predisposes patients to an increased risk of sudden cardiac death, especially in the setting of preexcited atrial fibrillation. WPW syndrome is usually sporadic and of unknown etiology in most cases. During the past 10 years, a significant heritable factor is increasingly recognized. Identification of the genetic basis among patients with WPW syndrome has important implications for understanding the molecular mechanism of ventricular preexcitation and the development of therapeutic strategies for risk stratification and management. The goal of this review is to examine the previous studies on hereditary variants, as well as to outline potential future avenues toward defining the heritability of WPW syndrome

PO-238 Urinary metabolomics study on the anti-depression effect of different exercise modes on CUMS model rats

Objective To study the effects of different exercise modes on CUMS depression model rats by 1H-NMR metabolomics technique, and to explore the mechanism of exercise anti-depression and to find the best exercise mode. Methods Forty-eight male SD rats were divided into control group (group C), model group (group M), aerobic exercise group (group A), and resistance exercise group (group R), 12 per group. The group C was routinely reared, chronic mild unpredictable stress + orphaned 8 weeks to establish a depression model of CUMS rats. In the 5th week of modeling, rats in group A and group R were trained in aerobic and resistance exercise for 4 weeks. The changes of body mass were observed during the experiment. The effects of exercise on the behavior of CUMS rats were observed by sucrose preference experiment and open field experiment. The levels of plasma BDNF, CORT and 5-HT were measured to reveal the pathological changes of the model. 1H-NMR metabolomics techniques combined with multivariate statistical analysis methods were used to investigate the regulation of urinary endogenous metabolites and the regulation of metabolic pathways in CUMS depression rats.  Results 1) After four weeks of modeling, compared with the group C, the body weight, saccharide water preference rate, the crossing number and the number of erectings in the group M, group A and group R were significantly lower (P<0.05 or P< 0.01), indicating that the modeling was successful; after eight weeks of modeling, compared with the group C, the body weight, saccharide water preference rate, the crossing number and the number of erectings in the group M, was significantly lower (P<0.01). There was no significant difference in the group A and group R. 2)Compared with group C, the levels of BDNF and 5-HT in group M were significantly decreased (P<0.05 or P<0.01), the level of CORT was significantly increased (P<0.01), and the levels of BDNF, 5-HT and CORT in group A were not significantly different, the CORT levels were significantly increased in group R(P <0.01), BDNF and 5-HT levels were not significantly different; compared with group M, BDNF, 5-HT levels in group A were significantly increased (P <0.05) and the level of CORT was significantly decreased (P<0.01), the levels of BDNF and 5-HT in group R were significantly increased (P<0.01), but there was no significant difference in CORT level. Compared with group A, the levels of BDNF and 5-HT in group R were not significant,but CORT levels increased significantly (P<0.05). 3)A total of 14 potential biomarkers in the urine of CUMS depression model rats were found . Compared with group C, the levels of leucine, valine, lactic acid, citric acid, inositol, pyruvic acid, β-hydroxybutyric acid, acetoacetic acid, trimethylamine, pantothenic acid, β-hydroxyisovaleric acid, alanine and succinic acid in the urine of group M were significantly increased, and the level of α-ketoglutaric acid was significantly decreased (P<0.05 or P<0.01). Group A can significantly callback 8 potential biomarkersof leucine, lactic acid, citric acid, pyruvic acid, β-hydroxybutyric acid, alanine, lactic acid and pantothenic acid (P<0.05 or P<0.01) , the group R can significantly callbackt the 6 potential biomarkers of lactic acid, acetoacetic acid, inositol, trimethylamine, β-hydroxy isovaleric acid and alanine. Two types of exercise can regulate urinary metabolites in depressed rats. 4) 1H-NMR metabolic pathway analysis showed that aerobic exercise mainly improves the urine metabolism of depressed rats by regulating TCA cycle, pantothenic acid and COA biosynthesis, and pyruvate metabolism. The resistance exercise mainly improved the urine metabolism characteristics of depressed rats by regulating the synthesis and degradation of ketone bodies, pyruvate metabolism and inositol phosphate metabolism. Conclusions Aerobic exercise and resistance exercise all can effectively improve depressive symptoms, adjust the urine biomarkers of depressed rats to varying degrees, which may be related to different metabolic pathways involved in exercise modes. &nbsp

Switching fractioned R-CHOP cycles to standard r-chop cycles guided by endoscopic ultrasonography in treating patients with primary gastric diffuse large B-cell lymphoma

© 2020 Liu et al. Background: Primary gastric diffuse large B-cell lymphoma (PG-DLBCL) is a common subtype of extranodal non-Hodgkin lymphoma (NHL), with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) as the commonly used treatment regimen. However, full cycles of standard R-CHOP present the risk of severe bleeding or perforation, even leading to emergency surgery, especially for those with deep lesions in their first 1–2 cycles of treatment. This study aims to explore the safety and efficacy of fractioned R-CHOP (rituximab d0, 50% dose of CHOP d1 and d5) followed by standard R-CHOP cycles in PG-DLBCL patients guided by endoscopic ultrasonography (EUS). Patients and Methods: Thirty-one PG-DLBCL patients were analyzed in this retrospective study. All patients had lesions infiltrated to at least the 3rd layer of the stomach under EUS at baseline. Patients switched to standard R-CHOP if they showed the reduced infiltrated layers and restricted lesions after fractioned R-CHOP cycles. Results: The overall response rate, 5-year progression-free survival (PFS) and overall survival (OS) of patients in our study were 93.5%, 75% and 84%, respectively. No treatment delay or dosage reduction from gastric adverse event was observed. None of the patients in our study suffered from severe bleeding or perforation during the treatment. Kaplan–Meier analyses showed that PG-DLBCL patients characterized by multiple localization, lesions ≥3cm, having B symptoms, lower serum albumin level, and elevated LDH level were associated with worse PFS and OS. Conclusion: Our data indicate that it might be an effective approach in treating deeply infiltrated PG-DLBCL patients by switching fractioned R-CHOP to standard R-CHOP cycles guided by EUS

PO-217 Plasma metabolomics study on the anti-depression effect of different exercise modes on CUMS model rats

Objective Objective: To study the anti-depression effect of different modes of exercise on CUMS rats and explore the mechanism by 1 H-NMR metabonomics methods. Methods Methods: Healthy male SD rats were got on sugar consumption training within one week of adaptive feeding, rats with similar scores were then randomly divided into control group (group C), model group (group M), aerobic exercise group (group A), and resistance exercise group (group R) by open field test. Chronic unpredictable mild stress (CUMS) procedure was conducted for four weeks, assess the success or failure of the model through behavioral indicators (rat increased amount of body weight, sucrose preference, crossings and rearings in open field test). The rats that were successfully modeled continued to undergo CUMS procedure for four weeks, and the rats in group A and group R were given different exercise training at the same time. After the end of training, the rats were executed and the blood sample was taken from the abdominal aorta to determine plasma superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-PX) activity and malondialdehyde (MDA) content. In order to further explore the mechanism of action of different exercise modes, the plasma was analyzed by 1H-HMR metabonomics technique and the metabolic pathways were analyzed by metaboAnalyst. Results Results: 1) After 4 weeks of CUMS, the behavioral indicators of group M, group A and group R were significantly lower than those of group C (p＜0.05，p＜0.01，p＜0.001), indicating that the rat model of CUMS was prepared successfully. 2) After 4 weeks of exercise intervention, the behavioral indicators, SOD, CAT and GSH-PX activities of rats in group C, group A and group R were significantly higher than those in group M(p＜0.05，p＜0.01), MDA content is significantly lower than that in group M (p＜0.01), there was no significant difference in behavioral and biochemical indicators between the group A and the group R. 3)A total of fifteen pathological markers were found in group M, such as isoleucine, valine, N-acetyl glycoprotein and so on (P<0.05 and VIP>1). Six metabolites among the fifteen pathological markers reverted significantly afteraerobic exercise training (P<0.05 or P<0.001), such as N-acetyl glycoprotein, leucine, lactic acid, LDL, glucose and acetoacetate, which mainly involved in 3 metabolic pathways including ketone bodies, butanoate metabolism, and biosynthesis of branched-chain amino acids. Another six metabolites reverted significantly after resistance exercise training (P<0.01 or P<0.001), such as lactic acid, glucose, creatine phosphate, acetoacetic acid, inositol and choline, which mainly involved in 3 metabolic pathways including ketone bodies, butanoate metabolism, and inositol phosphate metabolism. The above results suggest that both modes of exercise can improve the characteristics of plasma metabolites of depressed rats. Conclusions Conclusion: Different modes of exercise can effectively improve depressive symptoms, reduce the oxidative stress and adjust the plasma biomarkers of depressed rats to varying degrees, which may be related to different metabolic pathways involved in exercise modes. &nbsp

Prevalence of picky eating behaviour in Chinese school-age children and associations with anthropometric parameters and intelligence quotient. A cross-sectional study

AbstractPrevious studies have demonstrated the importance of eating behaviour regarding dietary variety and nutrient intake of children. However, the association between picky eating and growth of children is still a topic of debate. This study sought to estimate the prevalence of picky eating and to identify possible associations with the growth of school-age children in China. In this survey, 793 healthy children aged 7–12 years were recruited from nine cities and rural areas in China using a multi-stage cluster sampling method. Data collected included socio-demographic information and parents' perceptions of picky eating using a structured questionnaire, nutrient intake using 24-hour dietary recall, weight and height using body measurements, and intelligence using the Wechsler Intelligence Scale for Children. Blood samples were collected and analysed for minerals. The prevalence of picky eating reported by parents was 59.3% in children. Compared with non-picky eaters, picky eaters had a lower dietary intake of energy, protein, carbohydrates, most vitamins and minerals, and lower levels of magnesium, iron, and copper in the blood (p < 0.05), and also had a 0.184 z-score lower in height for age (95% CI: −0.332, 0.036; p = 0.015), a 0.385 z-score lower in weight for age (95% CI: −0.533, −0.237; p < 0.001), a 0.383 z-score lower in BMI for age (95% CI: −0.563, −0.203; p < 0.001), and scored 2.726 points higher on the intelligence test (95% CI: 0.809, 4.643; p = 0.006) when adjusted for children's birth weight and food allergy, mothers' education, and family income. Picky eating behaviour towards meat, eggs and vegetables showed negative associations with growth. Picky eating behaviour is prevalent in school-age children in China and may have a negative effect on growth

PO-194 Urinary metabolomics study on effects of Rhodiola on Marathon Amateurs after Quantitative Exercise Load

Objective To study&nbsp;the effect of Chinese medicine Rhodiola on oxidative stress injury in amateur marathon runners after quantitative exercise load&nbsp;(20 km) and explore its mechanism. Methods Eight marathon amateurs were divided into four groups according to different test time, including before and after quantitative exercise load&nbsp;(group C and group CE), before and after quantitative exercise load&nbsp;after taking a month of the Rhodiola&nbsp;(group MC and group ME). The participants had serum superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC) and malondialdehyde (MDA), as well as myocardial enzyme index - creatine kinase (CK), lactate dehydrogenase (LDH), creatine kinase isoenzyme (CK-MB) and glutamic oxaline aminotransferase (AST/GOT) activity&nbsp;evaluated. In order to further explore the mechanism of action of Rhodiola, the urine&nbsp;was analyzed by 1H-HMR&nbsp;metabonomics technique. Results 1) Compared with group C, the activity of&nbsp;serum CK, LDH and AST/GOT&nbsp;of group CE increased significantly (P&lt;0.01 or P&lt;0.05), MDA content and SOD activity also increased significantly (P&lt;0.05). A total of fifteen potential biomarkers were found in group CE, such&nbsp;as valine, lactic acid, 2- hydroxy isobutyric acid and so on (P&lt;0.05 and VIP&gt;1). 2) Compared with group CE, the activity of serum CK and AST/GOT&nbsp;and the content of MDA of group ME decreased significantly (P&lt;0.05), eleven metabolites among the fifteen potential biomarkers reverted significantly (P&lt;0.01 or P&lt;0.05), which mainly involved in 4 metabolic pathways&nbsp;including alanine, aspartic acid and glutamic acid metabolism and so on. Conclusions Rhodiola can enhance the antioxidant capacity and improve myocardial damage of&nbsp;marathon amateurs after quantitative exercise&nbsp;load, which may&nbsp;be due to&nbsp;increased&nbsp;synthesis and utilization of aminoacyl-tRNA and other amino acids