The Effects of Yoga on College Students\u27 Mental Health: A Systematic Review

The mental health of college students is an increasingly serious public health problem. Effective and healthy interventions are needed. More and more research has been conducted on yoga, but there are few randomized controlled trials (RTC) on effects of yoga intervention on students\u27 mental health. Therefore, this study examined effects of quality of yoga intervention on mental health in college students. We used PubMed (Medline), Cochrane, Web of Science, CNKI, VIP Chinese Science and Technology Journal Database (VIP) and WanFang Database to search randomized controlled trials (RCTs) of yoga intervention in college students\u27 mental health. After the screening, 17 articles met the requirements and were included along with the utilization of the Cochrane bias risk assessment tool Rob2.0 to evaluate the quality of the included articles. Of 17 articles reviewed, three articles were rated as low risk of bias , five articles were rated as possibly at risk of bias , and nine articles were rated as high risk of bias . The 17 studies predominantly consist of low methodological quality and lack multi-centered, large-sample collaborative research. Almost all researchers mentioned the use of randomization in their articles, but they did not indicate which randomization method was used. There was no description of allocation concealment, blinding, case shedding, case follow-up etc., and it was impossible to judge whether the trial design was correct, or whether random grouping was, indeed, undertaken. This study found that most of the so-called randomized controlled trials are doubtful, which virtually reduces the strength and credibility of this study. Therefore, improving the research quality of yoga intervention and standardizing the writing of scientific research articles are the problems need to be solved in the current field of sports psychology research in China. Current evidence shows that yoga exercise can relax the body and mind, thereby improving the level of mental health, and complete yoga (exercise, breathing, meditation) significantly relieves the symptoms of depression. Performing yoga postures and exercises promotes blood circulation, effectively improves sleep, and regulates breathing to stabilize autonomic nerves, relieve stress, and eliminate mental tension. In the future, yoga practice can be used as a non-medical intervention to treat mental illness. The quality of the current randomized controlled trials of yoga intervention in the mental health of college students is generally low. Randomized controlled trials with reasonable methodological design, strict implementation, and sufficient follow-up time are still needed. It is recommended that researchers should strengthen the systematic study of clinical trial methodology and strictly refer to the Cochrane manual list for clinical research reports in order to improve the quality of literature reports

Cyprinus carpio Decoction Improves Nutrition and Immunity and Reduces Proteinuria through Nephrin and CD2AP Expressions in Rats with Adriamycin-Induced Nephropathy

Cyprinus carpio decoction (CCD) is a well-known Chinese food medicine formula, accepted widely as a useful therapy in preventing edema and proteinuria caused by renal disease. However, the mechanism underlying this effect remains unclear. The current study investigated the potential mechanism of CCD in alleviating nephropathy induced by adriamycin (ADR) in rats. 70  eight-week-old Wistar rats were randomly divided into normal, model, fosinopril, YD, YG groups. All rats except for the normal group received 6.5 mg/kg·bw of ADR injection into the vena caudalis once. Different doses of CCD (11.3 and 22.5 g kg−1) were lavaged to rats in YD and YG groups, respectively. Then the serum biochemical values of the total protein (TP), albumin (ALB), blood urea nitrogen (BUN), creatinine (Cr), electrolyte levels, and the urinary protein (UP) content in 12 hr urine were measured. Interleukin-4 (IL-4) and interferon (INF-γ) were measured by enzyme-like immunosorbent assay (ELISA). The pathomorphological analysis was observed using light and electron microscopy, and the expressions of nephrin and CD2-associated protein (CD2AP) in renal tissues were determined by immunohistochemical assay. The results indicated that CCD can relieve ADR-induced nephropathy (ADN) by improving the nutrition status, regulating the immunity, and inhibiting proteinuria by increasing nephrin and CD2AP expressions

Dysregulation of circulating T follicular helper cell subsets and their potential role in the pathogenesis of syphilis

IntroductionThe role of the host immune response could be critical in the development of Treponema pallidum (Tp) infection in individuals with latent syphilis. This study aims to investigate the alterations in T follicular helper T (Tfh) cell balance among patients with secondary syphilis and latent syphilis.Methods30 healthy controls (HCs), 24 secondary syphilis patients and 41 latent syphilis patients were enrolled. The percentages of total Tfh, ICOS+ Tfh, PD-1+ Tfh, resting Tfh, effector Tfh, naïve Tfh, effector memory Tfh, central memory Tfh,Tfh1, Tfh2, and Tfh17 cells in the peripheral blood were all determined by flow cytometry.ResultsThe percentage of total Tfh cells was significantly higher in secondary syphilis patients compared to HCs across various subsets, including ICOS+ Tfh, PD-1+ Tfh, resting Tfh, effector Tfh, naïve Tfh, effector memory Tfh, central memory Tfh, Tfh1, Tfh2, and Tfh17 cells. However, only the percentages of ICOS+ Tfh and effector memory Tfh cells showed significant increases in secondary syphilis patients and decreases in latent syphilis patients. Furthermore, the PD-1+ Tfh cells, central memory Tfh cells, and Tfh2 cells showed significant increases in latent syphilis patients, whereas naïve Tfh cells and Tfh1 cells exhibited significant decreases in secondary syphilis patients when compared to the HCs. However, no significant change was found in resting Tfh and effector Tfh in HCs and secondary syphilis patients or latent syphilis patients.DiscussionDysregulated ICOS+ Tfh or effector memory Tfh cells may play an important role in immune evasion in latent syphilis patients

Continuous variable entanglement enhancement and manipulation by a sub-threshold type-II optical parametric amplifier

We experimentally demonstrate that the quantum entanglement between amplitude and phase quadratures of optical modes produced from a non-degenerate optical parametric amplifier (NOPA) can be enhanced and manipulated phase-sensitively by means of another NOPA. When both NOPAs operate at de-amplification, the entanglement degree is increased at the cavity resonance of the second NOPA. When the first NOPA operates at de-amplification and the second one at amplification, the spectral features of the correlation variances are significantly changed. The experimental results are in good agreement with the theoretical expectation

Matched-pair analysis of the impact of low-dose postoperative radiotherapy on prognosis in patients with advanced hypopharyngeal squamous cell carcinoma without positive surgical margins and extracapsular extension

BackgroundWe conducted a comparative analysis between low and high-dose postoperative radiotherapy in patients with hypopharyngeal squamous cell carcinoma (HPSCC) in stage III or IV without positive surgical margins and extracapsular extension (ECE). Propensity score matching (PSM) was used to eliminate confounding factors and reduce bias.MethodsThe matched-pair analysis included 156 patients divided into two groups: the low-dose radiotherapy group (LD-RT 50 Gy, 78 cases) and the high-dose radiotherapy group (HD-RT 60 Gy, 78 cases). Both cohorts were statistically comparable in terms of age, gender, subsite, and TNM classification.ResultsThe median follow-up time was 49 months (ranging from 5 to 100 months). The overall survival (OS) rate, progression-free survival (PFS) rate, locoregional control rate (87% vs. 85.7%; p = 0.754), distant metastases-free survival (79.2% vs. 76.6%; p = 0.506), and the occurrence of second primary tumors (96.1% vs. 93.5%; p = 0.347) showed no significant differences between the LD-RT group and the HD-RT group. The 3-year OS was 64.9% and 61% in the low-dose and high-dose group, respectively, and 63% in the entire group (p = 0.547). The 3-year PFS was 63.6% and 54.5% (p = 0.250), respectively, and the 3-year PFS of the entire group was 59.1%. Multivariate analyses revealed that pathological T and N classification, and pathological differentiation were associated with 3-year OS, PFS, and LRFS and were independent prognostic factors (p < 0.05). LD-RT was not associated with an increased risk of death and disease progression compared to HD-RT.ConclusionThe results of postoperative low-dose radiotherapy did not show inferiority to those of high-dose radiation for patients with advanced hypopharyngeal cancer without positive surgical margins and ECE in terms of OS, PFS, locoregional control, and metastases-free survival

Promicanje pravedne raspodjele kvalitetnog odgoja i obrazovanja u ranom djetinjstvu u ruralnim i urbanim područjima u Kini: studija slučaja modela ruralno-urbanog kontinuuma

Through the case of the rural-urban continuum model in China, this study aimed at evaluating the effectiveness of local government’s policy intervention in promoting equitable quality of early childhood education in rural and urban areas through multi-stakeholders’ voices. With simultaneous mixed method approach and self-developed instruments, the authors collected 891 valid parent questionnaires, 184 teacher questionnaires, 52 observational evaluation scales, and conducted interviews with 13 kindergarten principals and 6 administrators. The data were analysed by SPSS and NVIVO Plus. The findings show that a) rural and urban parents’ satisfaction levels had significant difference in terms of kindergartens’ cost and environment conditions; b) rural and urban teachers exhibited significant difference only when evaluating their professional attitudes and access to material support; c) researchers found no significant difference in quality of play activities and group teaching between rural and urban kindergarten classes, while significant difference was found in child care activities; d) principals perceived positively the effectiveness of the RUC model, yet had big concerns about teachers’ quality, and e) government intervention was proved to be a key factor enhancing equitable quality in rural and urban areas.Cilj ove studije je, putem slučaja trajnog modela ruralno-urbanog razvoja u Kini, glasovima više dionika provesti evaluaciju učinkovitosti intervencija lokalnih vlada na razini politika u promoviranje pravedne kvalitete predškolskog odgoja i obrazovanja u ruralnim i urbanim područjima. Primjenom pristupa istodobno kombiniranih metoda i instrumenata koje su istraživači sami razvili, autori su izradili 891 upitnik za roditelje, 184 upitnika za učitelje, 52 evaluacijska upitnika, te su proveli intervjue s 13 ravnatelja dječjih vrtića i 6 administratora. Podatke su analizirali s pomoću SPSS i NVIVO Plus. Rezultati pokazuju: a) da se razina zadovoljstva cijenom vrtića i uvjetima uvelike razlikuje između ruralnih i urbanih roditelja, b) da se ruralni i urbani učitelji uvelike razlikuju samo u evaluaciji svojih profesionalnih stavova i pristupa materijalnoj podršci, c) da istraživači nisu našli značajne razlike u kvaliteti aktivnosti igara i grupnom podučavanju između sati u ruralnim i urbanim vrtićima; značajne razlike su ustanovljene u aktivnostima skrbi za djecu, d) da ravnatelji učinkovitost modela RUC ocjenjuju pozitivno, no dosta ih se brine o kvaliteti učitelja, e) da su se vladine intervencije pokazale ključnim čimbenikom u povećanju pravedne kvalitete obrazovanja u ruralnim i urbanim područjima

Proteomics study of changes in soybean lines resistant and sensitive to Phytophthora sojae

<p>Abstract</p> <p>Background</p> <p><it>Phytophthora sojae </it>causes soybean root and stem rot, resulting in an annual loss of 1-2 billion US dollars in soybean production worldwide. A proteomic technique was used to determine the effects on soybean hypocotyls of infection with <it>P. sojae</it>.</p> <p>Results</p> <p>In the present study, 46 differentially expressed proteins were identified in soybean hypocotyls infected with <it>P. sojae</it>, using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization tandem time of flight (MALDI-TOF/TOF). The expression levels of 26 proteins were significantly affected at various time points in the tolerant soybean line, Yudou25, (12 up-regulated and 14 down-regulated). In contrast, in the sensitive soybean line, NG6255, only 20 proteins were significantly affected (11 up-regulated and 9 down-regulated). Among these proteins, 26% were related to energy regulation, 15% to protein destination and storage, 11% to defense against disease, 11% to metabolism, 9% to protein synthesis, 4% to secondary metabolism, and 24% were of unknown function.</p> <p>Conclusion</p> <p>Our study provides important information on the use of proteomic methods for studying protein regulation during plant-oomycete interactions.</p

Integrated Management of Industrial and Municipal Wastewater in China. - Demonstration Project in Jiaxing, Zhejiang Province

Årsliste 2000The city of Jiaxing in Zhejiang Province is a medium-size, rapidly expanding Chinese city located in a flat landscape with numerous canals. These are used for navigation, fishing, aquaculture and as drinking and industrial water source, but also as recipients for domestic and industrial wastewater and runoff from agriculture, paved roads and solid waste landfills in the area. The canals are severely polluted. NIVA has been assisting Jiaxing Environmental Protection Bureau (JEPB) in finding solutions to the local wastewater problems. The industry in the area discharges substantial quantities of potentially toxic wastewater to the sewer systems. There are, however, good possibilities for cleaner production routines in various factories. Several measures facilitate the transport of sewage to the nearby Hangzhou Bay, and sewage treatment processes before final disposal have been identified. The project has identified current and future wastewater production and recipient status. Based on pilot-plant operation and computer models a complete system for sewage collection and treatment has been suggested. This is based on transport of untreated sewage to Hanfzhou Bay where the construction of a sewage treatment plant is planned. The treatment methodology is based on a flexible chemically enhanced primary treatment (CEPT), followed by a biological step at a later stage. The project findings put emphasis on knowledge transfer and strengthening of JEPB resources to find solutions to the water-related problems in the city. In addition a detailed abatement plan should be developed, taking existing water quality, user interests and future water quality objectives into account.Direktoratet for Utviklingshjelp (NORAD

High expression of ubiquitin-conjugating enzyme 2C (UBE2C) correlates with nasopharyngeal carcinoma progression

BACKGROUND: Overexpression of ubiquitin-conjugating enzyme 2C (UBE2C) has been detected in many types of human cancers, and is correlated with tumor malignancy. However, the role of UBE2C in human nasopharyngeal carcinoma (NPC) is unclear. In this study, we investigated the role of aberrant UBE2C expression in the progression of human NPC. METHODS: Immunohistochemical analysis was performed to detect UBE2C protein in clinical samples of NPC and benign nasopharyngeal tissues, and the association of UBE2C expression with patient clinicopathological characteristics was analyzed. UBEC2 expression profiles were evaluated in cell lines representing varying differentiated stages of NPC and immortalized nasopharyngeal epithelia NP-69 cells using quantitative RT-PCR, western blotting and fluorescent staining. Furthermore, UBE2C was knocked down using RNA interference in these cell lines and proliferation and cell cycle distribution was investigated. RESULTS: Immunohistochemical analysis revealed that UBE2C protein expression levels were higher in NPC tissues than in benign nasopharyngeal tissues (P<0.001). Moreover, high UBE2C protein expression was positively correlated with tumor size (P=0.017), lymph node metastasis (P=0.016) and distant metastasis (P=0.015) in NPC patients. In vitro experiments demonstrated that UBE2C expression levels were inversely correlated with the degree of differentiation of NPC cell lines, whereas UBE2C displayed low level of expression in NP-69 cells. Knockdown of UBE2C led to significant arrest at the S and G2/M phases of the cell cycle, and decreased cell proliferation was observed in poorly-differentiated CNE2Z NPC cells and undifferentiated C666-1 cells, but not in well-differentiated CNE1 and immortalized NP-69 cells. CONCLUSIONS: Our findings suggest that high expression of UBE2C in human NPC is closely related to tumor malignancy, and may be a potential marker for NPC progression

SiNiSan Ameliorates the Depression-Like Behavior of Rats That Experienced Maternal Separation Through 5-HT1A Receptor/CREB/BDNF Pathway

Background: Early adverse life stress is an important dangerous factor in the development of psychiatric disorders, particularly depression. Available clinical antidepressant agents, such as fluoxetine, [a selective serotonin reuptake inhibitor (SSRI)], are unsatisfactory because of their side effects. SiNiSan (SNS) is a classic Chinese medicine prescription regarded to disperse stagnated liver qi to relieve qi stagnation. Therefore, this study was designed to detect the effects and molecular mechanism of SNS treatment in rats subjected to maternal separation (MS).Method: Male neonatal Wistar rats were divided into six groups including control + ddH2O, MS + ddH2O, MS + fluoxetine (5 g/kg), MS + SNS -low dose (2.5 g/kg), MS + SNS -medium dose (5 g/kg), MS + SNS -high dose (10 g/kg). The volume of drugs and ddH2O in each group are according to the weight of rats every day (10 mL/kg). Each group comprised 16 pups with 8 young and 8 adult pups. Except for the control group, all MS groups were separated from their mothers for 4 h/day from 9:00 to 13:00 during postnatal days (PNDs) 1 to 21. After MS, the six groups were intragastrically administered with ddH2O, fluoxetine, and different doses of SNS until PND 28 (for young pups) and PND 56 (for adult pups). The pups were weighed every day, and depression-like behavior was assessed by sucrose preference test, open field test, and forced swimming test. Serotonin 1A (5-HT1A) receptor, phosphorylated protein kinase A (p-PKA) substrate, cAMP response element-binding protein (CREB), p-CREB and brain-derived neurotrophic factor (BDNF) in the hippocampus were examined by Western blot, and in situ 5-HT1A receptor expression was measured by IHC.Results: Young and adult MS rats exhibited depression-like behavior. However, the depression-like behavior was ameliorated by SNS in both age groups. The levels of 5-HT1A receptor, p-CREB, and BDNF in the hippocampus were reduced in young and adult MS rats. SNS treatment significantly up-regulated the expression of 5-HT1A receptor, p-CREB, and BDNF in the hippocampus of adult MS rats. However, few significant effects on the protein expression were observed in the young MS rats.Conclusion: MS in infancy could develop depression-like behavior in young and adult. SNS treatment may perform antidepressant effects on young and adult MS rats through the BDNF/PKA/CREB pathway