Time and magnitude of responses were estimated from the time course microarray data using 1

5-fold expression changes as a threshold (C), and then used as coordinates in a scatter-plot. Tentative target genes were identified as shown in Fig 1.<p><b>Copyright information:</b></p><p>Taken from "Identification of , , and downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data"</p><p>http://www.biomedcentral.com/1471-2164/9/269</p><p>BMC Genomics 2008;9():269-269.</p><p>Published online 3 Jun 2008</p><p>PMCID:PMC2424064.</p><p></p

Examples of tentative target genes responding differentially to the suppression of , , and

<p><b>Copyright information:</b></p><p>Taken from "Identification of , , and downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data"</p><p>http://www.biomedcentral.com/1471-2164/9/269</p><p>BMC Genomics 2008;9():269-269.</p><p>Published online 3 Jun 2008</p><p>PMCID:PMC2424064.</p><p></p

Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary-1

or testis by at least two-fold. Functional categories of genes were assembled from GO annotations and from PubMed.<p><b>Copyright information:</b></p><p>Taken from "Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary"</p><p>http://www.biomedcentral.com/1741-7007/6/24</p><p>BMC Biology 2008;6():24-24.</p><p>Published online 3 Jun 2008</p><p>PMCID:PMC2426674.</p><p></p

microRNAs differentially expressed at PND1 and PND70.

<p>microRNAs differentially expressed at PND1 and PND70.</p

HSP70 and SREBP1 expression in livers of 10 week old mice.

<p>A. Western blot analysis of HSP70 and SREBP1. The SREBP1 fragment shown is the 68 kDa cleavage fragment. B. Densitometric quantitation of western blots. Signals for each protein were normalized to GAPDH and mean of controls (#’s 1–4) was set = 1. Representative of triplicate blots shown. * = p<0.05.</p

Identification and analyses of 51 genes differentially expressed at both PND1 and PND70.

<p>A. Intersection of genes differentially expressed at PND1 and PND70. B. Hierarchical clustering of 51 genes differentially expressed at both PND 1 and PND70. C. Principal component analysis of 51 genes differentially expressed at both PND 1 and PND70. (Arrows added for clarity) D. Pathway Architect analysis of 51 genes differentially expressed at both PND 1 and PND70.</p

Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary-2

or testis by at least two-fold. Functional categories of genes were assembled from GO annotations and from PubMed.<p><b>Copyright information:</b></p><p>Taken from "Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary"</p><p>http://www.biomedcentral.com/1741-7007/6/24</p><p>BMC Biology 2008;6():24-24.</p><p>Published online 3 Jun 2008</p><p>PMCID:PMC2426674.</p><p></p

Interactome maps of differentially expressed mRNAs in livers of arsenic-exposed mice.

<p>A. PND1; B. PND70. Major hubs are annotated.</p

Gene ontology of differentially expressed microRNA target mRNAs.

<p>Gene ontology of differentially expressed microRNA target mRNAs.</p

Transcription factor binding sites enriched in gene promoters of differentially expressed mRNAs that are targets of differentially expressed microRNAs in PND1 mice.

<p>A total of 101 unique Entrez gene IDs are gene targets of induced or suppressed microRNAs and appear in the gene list of differentially expressed mRNAs at PND1. A total 17 transcription factors are enriched for this gene set with a P-value <0.05.</p