The in vivo and in vitro studies of drug milk: Plasma distribution and assessing the risk to infant

Master'sMASTER OF SCIENCE (PHARMACY

VIGraph: Self-supervised Learning for Class-Imbalanced Node Classification

Class imbalance in graph data poses significant challenges for node classification. Existing methods, represented by SMOTE-based approaches, partially alleviate this issue but still exhibit limitations during imbalanced scenario construction. Self-supervised learning (SSL) offers a promising solution by synthesizing minority nodes from the data itself, yet its potential remains unexplored. In this paper, we analyze the limitations of SMOTE-based approaches and introduce VIGraph, a novel SSL model based on the self-supervised Variational Graph Auto-Encoder (VGAE) that leverages Variational Inference (VI) to generate minority nodes. Specifically, VIGraph strictly adheres to the concept of imbalance when constructing imbalanced graphs and utilizes the generative VGAE to generate minority nodes. Moreover, VIGraph introduces a novel Siamese contrastive strategy at the decoding phase to improve the overall quality of generated nodes. VIGraph can generate high-quality nodes without reintegrating them into the original graph, eliminating the "Generating, Reintegrating, and Retraining" process found in SMOTE-based methods. Experiments on multiple real-world datasets demonstrate that VIGraph achieves promising results for class-imbalanced node classification tasks

Biomineralization Induced by Colletotrichum acutatum: A Potential Strategy for Cultural Relic Bioprotection

Colletotrichum acutatum is a fungus capable of biomineralization reported in our previous study. In this paper, we compared the ability of this fungus to induce mineralization under different calcium sources, pH levels, and differing carbon availability. Here we found that organic acids, the alkalinity of the environment, and low carbon conditions were major factors influencing calcium carbonate precipitation. High performance liquid chromatography showed that citric acid was a metabolite produced by C. acutatum, and that other organic acids including formic, propionic, α-ketoglutaric, lactic, and succinic acids can be used by this fungus to promote CaCO3 formation. Based on these findings, the mechanism of the biomineralization induced by C. acutatum should be divided into three processes: secreting organic acid to dissolve limestone, utilizing the acid to increase the alkalinity of the microenvironment, and chelating free calcium ions with extracellular polymeric substances or the cell surface to provide a nucleation site. Interestingly, we found that hydroxyapatite rather than calcium carbonate could be produced by this fungus in the presence of phosphate. We also found that the presence of acetic acid could inhibit the transformation of vaterite to calcite. Further, we evaluated whether the proliferation of C. acutatum could influence the deterioration of stone relics. We found that low carbon conditions protected calcium carbonate from dissolution, indicating that the risk of degradation of limestone substrates caused by C. acutatum could be controlled if the fungi were used to consolidate or restore stone monuments. These results suggest that C. acutatum-induced biomineralization may be a useful treatment for deteriorated stone relics