Acid-Induced Multicolor Fluorescence of Pyridazine Derivative

Smart luminescent materials that are responsive to external stimuli have received considerable attention. Here, we report a new D–A type 1,2-pyridiazine derivative (3,4,5,6-tetrakis­(4-methoxyphenyl)­pyridazine (<b>TPP</b>)) exhibiting turn-on fluorescence upon acid exposure both in solution and in the solid state. The protonation of the 1,2-pyridiazine ring caused a variation in the emission colors of the acidification species from blue (406 nm) to orange-red (630 nm) with a huge Δλ_em (224 nm). As a result, a synthetic rainbow of emission in solution could be achieved from one single molecule, and white photoluminescence was readily tuned by controlled protonation. A trifluoroacetic acid (TFA)-sensor film made from <b>TPP</b> was demonstrated as a TFA-sensitive surface with high sensitivity and reversibility. On the basis of these findings, we constructed a solid-state <b>TPP</b> film with a photoacid generator and demonstrated data encryption and decryption via a cascade protonation reaction that was well controlled by UV light

<i>N</i>,<i>N</i>′‑Bicarbazole: A Versatile Building Block toward the Construction of Conjugated Porous Polymers for CO₂ Capture and Dyes Adsorption

<i>N</i>,<i>N</i>′-Bicarbazole with almost spatially vertical structure was synthesized by a facile method and was demonstrated as a versatile building block for conjugated microporous polymers (CMPs) through transition metal catalyzed coupling polymerizations including Yamamoto, Suzuki, and Sonogashira polymerizations. The porosities and morphologies of four <i>N</i>,<i>N</i>′-bicarbazole-based CMPs were systematically studied and compared. With high surface area, good thermal stability and microporous structure, the CMP synthesized by Yamamoto polymerization exhibited excellent adsorption capacities of CO₂ and organic dyes, and the maximum adsorption capacity of methylene blue (MB) in water reached up to 1016 mg g^–1. The good adsorption properties of <i>N</i>,<i>N</i>′-bicarbazole CMPs could be a good candidate for potential applications in water purification and treatment

Thiophene-Fused 1,10-Phenanthroline and Its Conjugated Polymers

A novel type of π-extended 1,10-phenanthroline, specifically with fused thiophene groups at the less exploited 3-, 4-, 7-, and 8-positions of the phenanthroline ring, and its conjugated polymers were designed and synthesized. The current developed route is based on the Bischler–Napieralski cyclization of the (1,2-phenylene)­diamide precursor, which offers a facile and versatile strategy for preparing soluble and well-defined 1,10-phenanthroline derivatives and their analogues. High molecular weight poly­(phenanthroline-<i>co</i>-fluorene)­s with good solubility in common organic solvents or water were prepared by palladium-catalyzed Suzuki–Miyaura–Schlüter polycondensation. The optical responsive properties of these thiophene-fused 1,10-phenanthroline-containing polymers have demonstrated these polymers could be a good candidate for potential applications as luminescent chemosensor materials thanks to the specific repeating unit along the backbone

Tuning the Mechanochromic Luminescence of BOPIM Complexes by Rational Introduction of Aromatic Substituents

Considering the great advantages of boron 2-(2′-pyridyl)­imidazole (BOPIM) based dyes, such as facile synthesis, high fluorescence quantum yield, large Stokes shift, and good thermal stability, three BOPIM complexes (<b>BOMPIM-Ph</b>, <b>BOPIM-Th</b>, and <b>BOPIM-TTh</b>) with different aromatic side groups have been developed. Their crystal structures and photophysical and mechanochromic luminescence properties were systematically studied. It was found that their solid state emission and mechanochromic behaviors are related to the side group. High color contrast reversible mechanochromism and piezochromism were observed for the three analogues, while <b>BOPIM-TTh</b> with more bulky thienothiophene groups showed a more sensitive and pronounced mechanochromic response. Steric and electronic effects of the aromatic donating substitutes were proved playing significant roles in regulating the intermolecular interactions and intramolecular charge transfer effect. Fine-tuning the molecular structures of such kind of BOPIM dyes allows convenient modulation of their optical properties and mechano-responsive behaviors

<i>S</i>,<i>N</i>‑Heteroacene-Based Conjugated Microporous Polymers as Fluorescent Sensors and Effective Antimicrobial Carriers

The synthetic control over pore structure and multifunctionality remain highly desirable for conjugated microporous polymers (CMPs). Here, we demonstrate that the 1,10-phenanthroline-like <i>S</i>,<i>N</i>-heteroacenes are ideal building blocks to construct a new kind of CMPs by Sonogashira polymerization. The enlarged conjugation and rigidity of the repeating units played a vital role in the formation of permanent micropores with large specific surface areas. The versatility of these CMPs for applications as fluorescent sensors and highly efficient antimicrobial carriers was explored. These fluorescent and electron-rich conjugated frameworks exhibit an optical sensing performance toward nitroaromatic explosives with a good selectivity and sensitivity. Moreover, for the first time, CMPs were used as heterogeneous antimicrobial carriers. The high microporosity, as well as the heterogeneous features of these CMPs, with specific interaction sites with silver, allows them efficient loading of silver nanoparticles with a well controlled size for effective antimicrobial activity

Thiophene-Fused 1,10-Phenanthroline and Its Conjugated Polymers

A novel type of π-extended 1,10-phenanthroline, specifically with fused thiophene groups at the less exploited 3-, 4-, 7-, and 8-positions of the phenanthroline ring, and its conjugated polymers were designed and synthesized. The current developed route is based on the Bischler–Napieralski cyclization of the (1,2-phenylene)­diamide precursor, which offers a facile and versatile strategy for preparing soluble and well-defined 1,10-phenanthroline derivatives and their analogues. High molecular weight poly­(phenanthroline-<i>co</i>-fluorene)­s with good solubility in common organic solvents or water were prepared by palladium-catalyzed Suzuki–Miyaura–Schlüter polycondensation. The optical responsive properties of these thiophene-fused 1,10-phenanthroline-containing polymers have demonstrated these polymers could be a good candidate for potential applications as luminescent chemosensor materials thanks to the specific repeating unit along the backbone

Hybrid Principal Component Analysis Denoising Enables Rapid, Label-Free Morpho-Chemical Quantification of Individual Nanoliposomes

Laser tweezers Raman spectroscopy enables multiplexed, quantitative chemical and morphological analysis of individual bionanoparticles such as drug-loaded nanoliposomes, yet it requires minutes-scale acquisition times per particle, leading to a lack of statistical power in typical small-sized data sets. The long acquisition times present a bottleneck not only in measurement time but also in the analytical throughput, as particle concentration (and thus throughput) must be kept low enough to avoid swarm measurement. The only effective way to improve this situation is to reduce the exposure time, which comes at the expense of increased noise. Here, we present a hybrid principal component analysis (PCA) denoising method, where a small number (∼30 spectra) of high signal-to-noise ratio (SNR) training data construct an effective principal component subspace into which low SNR test data are projected. Simulations and experiments prove the method outperforms traditional denoising methods such as the wavelet transform or traditional PCA. On experimental liposome samples, denoising accelerated data acquisition from 90 to 3 s, with an overall 4.5-fold improvement in particle throughput. The denoised data retained the ability to accurately determine complex morphochemical parameters such as lamellarity of individual nanoliposomes, as confirmed by comparison with cryo-EM imaging. We therefore show that hybrid PCA denoising is an efficient and effective tool for denoising spectral data sets with limited chemical variability and that the RR-NTA technique offers an ideal path for studying the multidimensional heterogeneity of nanoliposomes and other micro/nanoscale bioparticles

Sequencing analysis of p.S339L mutation in the <i>TLN2</i> gene (DNA).

<p>(A) Unaffected member (IV:2) of the family. (B) Patient (IV:1) with heterozygous p.S339L mutation. (C) Serine at position 339 is highly conserved across different animal species. (D) Cartoon representation of the model structure of the TLN2 protein by PyMOL 1.7 based on the CPHmodels-3.2: The serine and the mutated leucine at position 339 are shown as ball-and-stick models.</p

Camptodactyly phenotype and heart-associated characters in the <i>TLN2</i> p.S339L carriers.

<p>Camptodactyly phenotype and heart-associated characters in the <i>TLN2</i> p.S339L carriers.</p

Subcellular localization of TLN2.

<p>(A) Wild type TLN2. (B) The p.S339L mutant TLN2.</p