HAPPEN TO BE FASHIONABLE? : NEW PRACTICE CREATION THROUGH THE SEQUENCE OF MULTIPLE ACTORS

In contrast to previous research, this paper illustrates a process in which institutional entrepreneurs play less significant roles in creating a new practice. We drew on a historical case study that deals with the emergence of a new practice of emphasizing fashionable design of a type of clothing known as meisen. In the historical case study, multiple actors played distinctive and essential roles, which, as a whole, led to the creation of a new practice.

Rbとp53は、膵神経内分泌腫瘍形成において異なる役割を果たす

京都大学新制・論文博士博士(医学)乙第13418号論医博第2226号新制||医||1052(附属図書館)京都大学大学院医学研究科医学専攻(主査)教授 羽賀 博典, 教授 長船 健二, 教授 伊藤 貴浩学位規則第4条第2項該当Doctor of Medical ScienceKyoto UniversityDFA

ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration

The cellular events that precede myelination in the peripheral nervous system require rapid and dynamic morphological changes in the Schwann cell. These events are thought to be mainly controlled by axonal signals. But how signals on the axons are coordinately organized and transduced to promote proliferation, migration, radial sorting, and myelination is unknown. We describe that the axonal signal neuregulin-1 (NRG1) controls Schwann cell migration via activation of the atypical Dock180-related guanine nucleotide exchange factor (GEF) Dock7 and subsequent activation of the Rho guanine triphosphatases (GTPases) Rac1 and Cdc42 and the downstream c-Jun N-terminal kinase. We show that the NRG1 receptor ErbB2 directly binds and activates Dock7 by phosphorylating Tyr-1118. Dock7 knockdown, or expression of Dock7 harboring the Tyr-1118–to–Phe mutation in Schwann cells, attenuates the effects of NRG1. Thus, Dock7 functions as an intracellular substrate for ErbB2 to promote Schwann cell migration. This provides an unanticipated mechanism through which ligand-dependent tyrosine phosphorylation can trigger the activation of Rho GTPase-GEFs of the Dock180 family

Positions of Point-Nodes in Borocarbide Superconductor YNi2B2C

To determine the superconducting gap function of YNi2B2C, we calculate the local density of states (LDOS) around a single vortex core with the use of Eilenberger theory and the band structure calculated by local density approximation assuming various gap structures with point-nodes at different positions. We also calculate the angular-dependent heat capacity in the vortex state on the basis of the Doppler-Shift method. Comparing our results with the STM/STS experiment, the angular-dependent heat capacity and thermal conductivity, we propose the gap-structure of YNi2B2C, which has the point-nodes and gap minima along . Our gap-structure is consistent with all results of angular-resolved experiments.Comment: 7 pages, 5 figure

DETERMINATION OF INPUT LASER ENERGY FOR MELTING POWDER LAYERS OF VARIOUS THICKNESSES IN HIGH-SPEED PBF-LB/P USING NEARINFRARED LASER AND ABSORBENT

The rate of production of PBF-LB/P can be increased by increasing the layer thickness. However, this reduces the part resolution in the stacking direction. To obtain both a high rate of production and high part resolution, layer thickness adjustment in accordance with part geometry can be effective. Optimizing the input laser energy with respect to the layer thickness ensures sufficient melting and part strength. According to previous studies, the use of a nearinfrared laser and absorbent can increase penetration depth or depth of fusion. However, the optical properties of the powder bed can vary significantly depending on the layer thickness, and, therefore, the input energy that actually contributes to melting also changes with layer thickness. This study proposes a method for determining the input laser energy for various layer thickness without trial and error by estimating the amount of energy required to melt the powder layer while accounting for the optical properties of the bed.Mechanical Engineerin