331 research outputs found
Polysaccharide-based nanomedicines for cancer immunotherapy: a review
Cancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate
tumors by immunotherapeutics. However, direct administration of “naked” immunotherapeutic agents (such as
nucleic acids, cytokines, adjuvants or antigens without delivery vehicles) often results in: (1) an unsatisfactory
efficacy due to suboptimal pharmacokinetics; (2) strong toxic and side effects due to low targeting (or off-target)
efficiency. To overcome these shortcomings, a series of polysaccharide-based nanoparticles have been developed
to carry immunotherapeutics to enhance antitumor immune responses with reduced toxicity and side effects.
Polysaccharides are a family of natural polymers that hold unique physicochemical and biological properties, as
they could interact with immune system to stimulate an enhanced immune response. Their structures offer
versatility in synthesizing multifunctional nanocomposites, which could be chemically modified to achieve high
stability and bioavailability for delivering therapeutics into tumor tissues. This review aims to highlight recent
advances in polysaccharide-based nanomedicines for cancer immunotherapy and propose new perspectives on
the use of polysaccharide-based immunotherapeutics.info:eu-repo/semantics/publishedVersio
Genetic Variants at Newly Identified Lipid Loci Are Associated with Coronary Heart Disease in a Chinese Han Population
Recent genome-wide association studies (GWAS) have mapped several novel loci influencing blood lipid levels in Caucasians. We sought to explore whether the genetic variants at newly identified lipid-associated loci were associated with CHD susceptibility in a Chinese Han population. and 0.001, respectively).We identified two novel SNPs (rs599839 and rs16996148) at newly identified lipid-associated loci that were significantly associated with CHD susceptibility in a Chinese Han population
CGMP: cloud-assisted green multimedia processing
With continued advancements of mobile computing and communications, emerging novel multimedia services and applications have attracted lots of attention and been developed for mobile users, such as mobile social network, mobile cloud medical treatment, mobile cloud game. However, because of limited resources on mobile terminals, it is of great challenge to improve the energy efficiency of multimedia services. In this paper, we propose a cloud-assisted green multimedia processing architecture (CGMP) based on mobile cloud computing. Specifically, the tasks of multimedia processing with energy-extensive consumption can be offloaded to the cloud, and the face recognition algorithm with improved principal component analysis and nearest neighbor classifier is realized on CGMP based cloud platform. Experimental results show that the proposed scheme can effectively save the energy consumption of the equipment
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