9 research outputs found
Cu-Catalyzed Divergent Transformations of Allenylethylene Carbonates with Diboron Reagents
Divergent transformations of allenylethylene carbonates
with diboron
reagents catalyzed by copper are disclosed. By using CuCl/IPr·HCl
as the catalyst, the allenylethylene carbonates react with B2hex2 to afford 2,4-dien-1-ols as the product in the presence
of Cs2CO3 as the base, iPrOH as the additive, and 1,4-dioxane as the solvent. And they
react with B2pin2 to form boronic half acids
in the presence of NaOtBu as the base,
water as the additive, and THF as the solvent. The reactions afford
corresponding products in good stereoselectivities and yields, and
further derivatizations of boronic half acids and study of the mechanism
are also demonstrated
Table_1_Pregnancy outcomes following natural conception and assisted reproduction treatment in women who received COVID-19 vaccination prior to conception: a population-based cohort study in China.docx
IntroductionThe coronavirus disease-2019 (COVID-19) pandemic has swept across the world and continues to exert serious adverse effects on vulnerable populations, including pregnant women and neonates. The vaccines available at present were designed to prevent infection from COVID-19 strains and control viral spread. Although the incidence of pregnancy cycle outcomes are not likely to increase patients vaccinated prior to pregnancy compared with unvaccinated patients based on our knowledge of vaccination safety, there is no specific evidence to support this hypothesis. Therefore, the current study aimed to investigate the association between maternal vaccination prior to conception and pregnancy outcomes.MethodsWe retrospectively analyzed 2,614 women who received prenatal care and delivered in the Obstetrical Department of The First Affiliated Hospital of Anhui Medical University between February 2022 and November 2022. Of the 1,380 eligible pregnant women, 899 women who had received preconception vaccination were assigned to a vaccine group and 481 women who were not vaccinated were control group. Of the enrolled patients, 291 women received fertility treatment (141 vaccinated women, 150 unvaccinated women). The primary outcomes were pregnancy complications (hypothyroidism, gestational diabetes mellitus, pregnancy-induced hypertension, polyhydramnios, oligohydramnios, premature rupture of membranes and postpartum hemorrhage), obstetric outcomes (preterm birth rate, cesarean section rate) and neonatal outcomes (birth-weight, body length, low-birth-weight rate, rate of congenital defects, neonatal mortality and admission to the neonatal intensive care unit).ResultsThere was no significant difference in the incidence of complications during pregnancy and delivery when compared between the vaccine group and control group in either univariate- or multivariate-models. The type of vaccine was not associated with the odds of adverse pregnancy outcome. Among the women with infertility treatment, the vaccinated group and the unvaccinated group had similar pregnancy outcomes.ConclusionWomen who received COVID-19 vaccination prior to conception had similar maternal and neonatal outcomes as women who were unvaccinated. Our findings indicate that COVID-19 vaccinations can be safely administered prior to pregnancy in women who are planning pregnancy or assisted reproductive treatment. During new waves of COVID-19 infection, women who are planning pregnancy should be vaccinated as soon as possible to avoid subsequent infections.</p
Univariate and multivariate analysis for overall survival.
<p>Univariate and multivariate analysis for overall survival.</p
Comparison of FISH and IHC in 430 patients and comparison of FISH and RT-PCR on detecting <i>ALK</i> rearrangements among 200 patients.
<p>Comparison of FISH and IHC in 430 patients and comparison of FISH and RT-PCR on detecting <i>ALK</i> rearrangements among 200 patients.</p
Progression-free survival (PFS) and overall survival (OS) among <i>ALK-</i>positive patients, patients who have <i>EGFR</i> activating mutations and wild type both <i>ALK</i> and <i>EGFR</i> (WT/WT).
<p>(A) PFS for patients receiving the first-line chemotherapy harboring <i>ALK</i> rearrangements, <i>EGFR</i> activating mutations, and WT/WT. (B) PFS for patients receiving EGFR TKIs harboring <i>ALK</i> rearrangements, <i>EGFR</i> activating mutations, and WT/WT. (C) OS for patients harboring <i>ALK</i> rearrangements, <i>EGFR</i> activating mutations, and WT/WT.</p
Detection of <i>ALK</i> rearrangements using Ventana immunohistochemistry (IHC) (200×).
<p>(A) An <i>ALK-</i>negative case without cytoplasmic staining. (B) An <i>EML4-ALK-</i>positive case with strong granular cytoplasmic staining. (C) A <i>KIF5B-ALK-</i>positive case identified by RT-PCR with strong granular cytoplasmic staining.</p
Detection of <i>ALK</i> rearrangements using Fluorescent in situ hybridization (FISH) (1000×).
<p>(A) An <i>ALK-</i>negative case. (B) An <i>ALK-</i>positive case with split signal pattern. (C) An <i>ALK-</i>positive case with isolated red signal pattern.</p
Additional file 1: of Dental noise exposed mice display depressive-like phenotypes
Supplementary material. (PPTX 18,329 kb