Visualization 1: Space- and intensity-constrained reconstruction for compressed ultrafast photography

Frame-by-frame comparison of the two reconstructed datacubes. Originally published in Optica on 20 July 2016 (optica-3-7-694

Visualization 2: Space- and intensity-constrained reconstruction for compressed ultrafast photography

Frame-by-frame comparison of the two reconstructed datacubes. Originally published in Optica on 20 July 2016 (optica-3-7-694

Table_1_The role of rare earth elements and dietary intake in tongue cancer: a mediation analysis in southeast China.DOCX

ObjectiveThe current research aimed to examine how dietary intake and rare earth elements may affect the development of tongue cancer.MethodsThe serum levels of 10 rare earth elements (REEs) in 171 cases and 171 healthy matched controls were measured by inductively coupled plasma mass spectrometry (ICP-MS). The conditional logistic regression was used to examine the relationship between dietary intake, serum levels of 10 REEs, and tongue cancer. Mediation effect and multiplicative interaction analysis were then performed to estimate the potential contribution of REEs in dietary intake associated with tongue cancer.ResultsCompared with the control group, patients with tongue cancer consumed significantly less fish, seafood, fruit, green leafy vegetables, and non-green leafy vegetables, with higher serum praseodymium (Pr), dysprosium (Dy), and lanthanum (La) levels, and lower serum cerium (Ce) and scandium (Sc) levels. The interaction effect was observed between some REEs and food categories. Green vegetables' impact on the risk of tongue cancer is partially attributed to the La and Thorium (Th) elements (P ConclusionThe correlation between REEs and dietary intakes for tongue cancer is compact but intricate. Some REEs interact with food intake to influence tongue cancer, while others act as a mediator.</p

The three main dense modules of DEGs.

<p>Each circled or triangle point represents a node in the network and each line represents the interaction between two nodes. Red node: up-expressed gene; green node: down-expressed gene; gray node: background gene; triangle node: gene included in the enriched pathway.</p

Immunohistochemical labeling of normal oral mucosa (A,D,G), oral leukoplakia (B,E,H) and oral squamous cell carcinoma (G,H,I) for MMP9 (A,B,C), BGH3 (D,E,F) and PDIA3 (G,H,I).

<p>Brown staining represents positive expression of proteins. MMP9 expression in stroma cells is low (A). Positive MMP9 cytoplasmic staining of basal cells in OLK (B). Strong nuclear and cytoplasmic MMP9 staining of OSCC (C). Negative BGH3 expression in NOM (D). Weak or moderate BGH3 staining of the basement membrane in OLK (E). Strong positive BGH3 expression in tumor basement membrane and extracellular skeletal stroma of OSCC (F). Negative PDIA3 staining in NOM (G). Moderate to strong PDIA3 staining in the cytoplasm and nucleus of OLK epithelium cells (H). High PDIA3 expression in the cytoplasm and cell membrane of OSCC (I).</p

DataSheet_1_Whole-genome sequencing of extrachromosomal circular DNA of cerebrospinal fluid of medulloblastoma.docx

BackgroundMedulloblastoma (MB) is a malignant tumor associated with a poor prognosis in part due to a lack of effective detection methods. Extrachromosomal circular DNA (eccDNA) has been associated with multiple tumors. Nonetheless, little is currently known on eccDNA in MB.MethodsGenomic features of eccDNAs were identified in MB tissues and matched cerebrospinal fluid (CSF) and compared with corresponding normal samples using Circle map. The nucleotides on both sides of the eccDNAs’ breakpoint were analyzed to understand the mechanisms of eccDNA formation. Bioinformatics analysis combined with the Gene Expression Omnibus (GEO) database identified features of eccDNA-related genes in MB. Lasso Cox regression model, univariate and multivariate Cox regression analysis, time-dependent ROC, and Kaplan–Meier curve were used to assess the potential diagnostic and prognostic value of the hub genes.ResultsEccDNA was profiled in matched tumor and CSF samples from MB patients, and control, eccDNA-related genes enriched in MB were identified. The distribution of eccDNAs in the genome was closely related to gene density and the mechanism of eccDNA formation was evaluated. EccDNAs in CSF exhibited similar distribution with matched MB tissues but were differentially expressed between tumor and normal. Ten hub genes prominent in both the eccDNA dataset and the GEO database were selected to classify MB patients to either high- or low-risk groups, and a prognostic nomogram was thus established.ConclusionsThis study provides preliminary evidence of the characteristics and formation mechanism of eccDNAs in MB and CSF. Importantly, eccDNA-associated hub genes in CSF could be used as diagnostic and prognostic biomarkers for MB.</p

Strain and Interference Synergistically Modulated Optical and Electrical Properties in ReS₂/Graphene Heterojunction Bubbles

Two-dimensional (2D) material bubbles, as a straightforward method to induce strain, represent a potentially powerful platform for the modulation of different properties of 2D materials and the exploration of their strain-related applications. Here, we prepare ReS2/graphene heterojunction bubbles (ReS2/gr heterobubbles) and investigate their strain and interference synergistically modulated optical and electrical properties. We perform Raman and photoluminescence (PL) spectra to verify the continuously varying strain and the microcavity induced optical interference in ReS2/gr heterobubbles. Kelvin probe force microscopy (KPFM) is carried out to explore the photogenerated carrier transfer behavior in both strained ReS2/gr heterobubbles and ReS2/gr interfaces, as well as the oscillation of surface potential caused by optical interference under illumination conditions. Moreover, the switching of in-plane crystal orientation and the modulation of optical anisotropy of ReS2/gr heterobubbles are observed by azimuth-dependent reflectance difference microscopy (ADRDM), which can be attributed to the action of both strain effect and interference. Our study proves that the optical and electrical properties can be effectively modulated by the synergistical effect of strain and interference in a 2D material bubble