46 research outputs found
æ°ç®¡æ¯åæ¯ã«å¯Ÿããè€åæž©æ³çæ³ã®äœçšæ©åº 2.å åæ³ïœ¥èªåŸç¥çµç³»ããã³å¿å çèŠçŽ ã«å¯Ÿããå¹æ
Actions of spa therapy on endocrine-autonomic nerve system and psychological factors were analyzed in patients with bronchial asthma. In endocrine function, serum levels of cortisol and ACTH tended to increase after spa therapy. In autonomic nerve system, decrease in concentrations of serum adrenalin and noradrenalin was observed after spa therapy, and the difference between the initial levels before spa therapy and the levels after the therapy was significant in serum levels of adrenalin. However, serum levels of substance P and Bradykinin were not affected by spa therapy. To evaluate the action of spa therapy on mental condition in patients with asthma, four kinds of psychological tests, CMI, SDS, CAl and SD, were carried out. Improvement of mental disorders in patients with asthma is observed after spa therapy in all psychological tests. These results suggest that spa therapy acts effectively on endocrine-autonomic nerve system and improve psychological conditions.å
åæ³ïœ¥èªåŸç¥çµç³»ããã³å¿å çèŠçŽ ã«å¯Ÿããæž©æ³çæ³ã®å¹æã,æ°ç®¡æ¯åæ¯ã察象ã«æ€èšãããå
åæ³ç³»ã§ã¯,è¡äžã³ãŒããŸ-ã«ããã³ACTHå€ã,æž©æ³çæ³åŸã«äžæããããšã瀺ããããŸã,èªåŸç¥çµç³»ã§ã¯,è¡äžã¢ãã¬ããªã³ããã³ãã«ã¢ãã¬ããªã³æ¿åºŠãæž©æ³çæ³ã«ããæžå°ããããšã瀺ãã,ç¹ã«,è¡äžã¢ãã¬ããªã³ã¯æž©æ³çæ³ååŸã®æ¿åºŠã«ææã®å·®ãèŠãããããããªãã,è¡äžãµãã¹ã¿ã³ã¹Pããã³ãã©ãžããã³æ¿åºŠã«ã¯,æž©æ³çæ³ã«ããææã®å€åã¯èŠãããªãã£ãå¿å çèŠçŽ ã«å¯Ÿããæž©æ³çæ³ã®äœçšãæ€èšãããã,CMI,SDS,CAIããã³SDã®4çš®é¡ã®å¿èº«å»åŠçæ€æ»ãè¡ããããã®çµæ,ãããã®å¿èº«å»åŠçæ€æ»ã«ãããŠã,æž©æ³çæ³ã«ããçŸæ£ã«äžå©ã«åãå¿å çèŠçŽ ãæ¹åããåŸåãèŠããããããã®çµæãã,æž©æ³çæ³ãå
åæ³ïœ¥èªåŸç¥çµç³»ã«å¯ŸããŠæçšãªäœçšãæã,ãŸã,çŸæ£ã«äžå©ãªå¿å çèŠçŽ ãæ¹åãããäœçšãæããŠããããšãããçšåºŠç€ºåããã
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To evaluate improvement of mental disorders by spa therapy for 1-2 months, three kinds of psychological examinations, CMI (Cornel Medical Index), SDS (Selfrating Depression Scale) and CAI (Comprehensive Asthma Inventory) tests, were
performed in 37 patients with asthma before and after spa therapy. 1. In CMI test, the scores of physical symptoms, respiratory symptoms, and CIJ symptoms significantly decreased after spa therapy. The score of psychical symptoms tended to decrease after the therapy, however, this was not significant. 2. The mean score of the subjects over 40 points in SDS test significantly decreased from 45.7 points before spa therapy to 37.5 after the therapy. 3. Mental disorders evaluated by various categories in CAI test were significantly improved after spa therapy. The average score in CAI test significantly decreased from 37.1 to 27.8 after the therapy. These results demonstrate that psychological disorders in patients with asthma are improved by spa therapy.æ°ç®¡æ¯åæ¯ã«å¯Ÿããæž©æ³çæ³(1-2ã¶æ)ã«ããå¿ççé害ã®æ¹åãè©äŸ¡ããããã«,3çš®é¡ã®å¿çåŠç調æ»:CMI(Cornel Medical Index),SDS(Selfrationg Depression Scale),CAI(Comprehensive Asthma Inventory)ã,æ°ç®¡æ¯åæ¯æ£è
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¥é¢æãšéé¢æã«å®æœãæ¯èŒããâ CMIã§ã¯,身äœçèªèŠç,åŒåžåšç³»çç¶ããã³CIJçç¶ã,æž©æ³çæ³åŸã«ææã«æ¹åããâ¡SDSå€ã40以äžã®çäŸã«ãããŠ,æž©æ³çæ³åŸ,å¹³åå€ã¯45.7ãã37.5ãžææã«æžå°ããâ¢CAIã®çš®ã
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ç®ã®å¹³åå€ã§ããCAIã¹ã³ã¢ã¯,æ²»çåŸ,37.1ãã27.8ãžææã«äœäžãããããã®çµæãã,æ°ç®¡æ¯åæ¯æ£è
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The degree and characteristic of airway inflammation were evaluated by the proportions of bronchoalveolar lavage (BAL) cells. Clinical asthma types such as Ia. simple bronchoconstriction, Ib. bronchoconstriction + hypersecretion, and â
¡. bronchiolar obstruction correlate with airway inflammation. The increased proportion BALãneutrophils is characteristic of type â
¡ asthma, and increase in BAL eosinophil count is often observed in type Ib asthma. Bronchial hyperresponsiveness also correlates
with airway inflammation. Action of spa therapy has been speculated to be related to airway inflammation, since the therapy has no action inhibiting IgE-mediated allergic reaction. In fact, spa therapy is more effective in patients with type Ib and type â
¡ than in those with type Ia showing slight degree of airway inflammation. Bronchial hyperresponsiveness is also improved by spa therapy. From a point of view, the direct action of spa therapy may be to clean airways and improve damaged mucous membrane of the airways, leading to suppression of airway inflammation.æ°éççåå¿ã®çšåºŠãç¹åŸŽã,æ°ç®¡æ¯èºèæŽæµæ¶²(BAL)äžã®çŽ°èæåã«ãã£ãŠè©äŸ¡ãããIa.åçŽæ§æ°ç®¡æ¯æ£çž®å,Ib.æ°ç®¡æ¯æ£çž®+éåæ³å,â
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žçå¢å€ã¯Ibååæ¯ã§ãã°ãã°èŠ³å¯ãããæ°ééææ§ããŸãæ°éççåå¿ãšé¢é£ããŠãã枩æ³çæ³ã®äœçšæ©åºãšããŠã¯,æž©æ³çæ³ã«IgEã«mediateãããã¢ã¬ã«ã®ãŒåå¿(液æ§å åçž)ãæå¶ããäœçšããªãããšãã,æ°éççåå¿(现èæ§å åçž)ã®æå¶ãæšæž¬ãããŠããå®é,æž©æ³çæ³ã¯,æ°éççåå¿ã軜床ãªIaååæ¯ã«æ¯ã¹,Ibåãâ
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Action mechanisms of complex spa therapy (swimming training in a hot spring pool, inhalation with iodine salt solution, and fango therapy) were studied in relation to patient age, clinical asthma type, and airway inflammation. Actions of spa therapy were observed by two clinical effects : direct and indirect effects. Improvement of subjective symptoms, ventilatory function, and bronchial hyperresponsiveness was observed as direct effects of spa therapy, and improvement of suppressed function of adrenocortical glands as indirect effects of the therapy. The clinical effects of spa therapy were higher in patients over the age of 40. Regarding clinical asthma type, the effects were larger in patients with type Ib and type II asthma than in those with type Ia. The efficacy of spa therapy was closely related with airway inflammation in patients with type Ib and type II asthma.è€åæž©æ³çæ³(æž©æ³ããŒã«æ°Žæ³³èšç·Ž,ãšãŒããŸã«åžå
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Iaå(åçŽæ°ç®¡æ¯ããçž®å)åæ¯ã«ãããæ°ééææ§ã«ã€ããŠâŠå¹Žéœ¢ããã³æ°ç®¡æ¯èºèæŽæµæ¶²äžã®çŽ°èæåãšã®é¢é£ã«ã€ããŠ
Bronchial hyperresponsiveness was examined in relation to age, ventilatory function, and the proportion of bronchoalveolar lavage (BAL) cells in 39 patients with type Ia asthma (simple bronchoconstriction) (25 with type Ia-1 and 14 with type Ia-2), classified by clinical symptoms. 1. The proportion of BAL eosinophils was significantly higher in type Ia-2 than that in type Ia-1 asthma patients. 2. Bronchial reactivity to methacholine was not different between type Ia-1 and type Ia-2 asthma patients. 3. Bronchial hyperreactivity tended to decrease as patient age was higher in both types of asthma. Neither ventilatory function (FEV1.0%) nor the proportions of BAL lymphocytes and neutrophils was not correlated with bronchial hyperresponsiveness in both types of asthma. 4. Bronchial reactivity to methacholine more dereased with the increase in the proportion of BAL eosinophils in both type Ia-1 and Ia-2 asthma patients. The results show that bronchial hyperresponsiveness in patients with type Ia asthma is correlated to patients age and the proportion of BAL eosinophils.æ°ç®¡æ¯åæ¯æ£è
Iaå(åçŽæ°ç®¡æ¯ããçž®å)39人(Ia-1å25人,Ia-2å14人)ã®æ°ééææ§ã幎霢,åŒåžæ©èœæ€æ»,æ°ç®¡æ¯èºèæŽæµæ¶²(BAL)äžã®çŽ°èæåãšé¢é£ã§æ€èšãè¡ã£ã1.BAL液äžã®å¥œé
žçã®æ¯çã¯Ia-1åã«æ¯ã¹Ia-2åã§åªäœã«é«å€ã§ãã£ã2.ã¡ãµã³ãªã³ã«å¯ŸããŠã®éææ§ã¯Ia-1åãšIa-2åãšã§å·®ãèªããªãã£ã3.æ°ééææ§ã¯ã©ã¡ãã®ç
åã«ãããŠã幎霢ã«ãšããªã£ãŠæžåŒ±ããåŸåã«ãã£ãã,äžç§çåã³BAL液äžã®å¥œäžç,ãªã³ãçã®æ¯çãšã¯çžé¢ããªãã£ã4.ã¡ãµã³ãªã³ã«å¯ŸããŠã®æ°ééææ§ã¯Ia-1å,Ia-2åãšãã«BAL液äžã®å¥œé
žçã®æ¯çãå¢å ããã«ãããã£ãŠäº¢é²ãã以äžããåçŽæ°ç®¡æ¯ããçž®å(Iaå)ã®æ°ç®¡æ¯åæ¯æ£è
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â ¡å(现æ°ç®¡æ¯éå¡)åæ¯ãšéå¡æ§çŽ°æ°ç®¡æ¯çã«ããã现æ°ç®¡æ¯é åã®ççåå¿ã®å·®
Ventilatory function and inflammatory cells in airways were compared between patients with type â
¡ (bronchiolar obstruction) asthma and those with obstructive bronchiolitis. 1. Age and age at onset were higher in patients with type â
¡ asthma than in those with obstructive bronchiolitis. IgE-mediated allergic reaction was observed in patients with type â
¡ asthma, but not in those with obstructive bronchiolitis. 2. In ventilatory function tests, all ventilatory parameters examined were lower in patients with type â
¡ asthma compared to those with obstructive bronchiolitis, and the differences were significant in FEV1.0% (p<0.001), % MMF (p<0.02), and V50 (p<0.01). 3. The proportion of BAL neutrophils was very high in type â
¡ asthma (55.7%) and obstructive bronchiolitis (74.4%), however, this was not significant. 4. Absolute numbers/BAL fluid of total cells, BAL macrophages and BAL neutrophils were significantly higher in patients with obstructive bronchiolitis than in those with type â
¡ asthma. 5. The results on absolute number/mâ of BAL cells demonstrated that number of BAL neutrophils markedly larger in patients with obstructive bronchiolitis compared to those with type â
¡ asthma. These results show that high proportion of BAL neutrophils was observed in the two respiratory diseases, however, the degree of inflammation in airways was markedly greater in obstructive bronchiolitis.â
¡ååæ¯ãšéå¡æ§çŽ°æ°ç®¡æ¯çã®èšåºçç¹åŸŽã«ã€ããŠ,ææ°æ©èœããã³æ°éççåå¿ãäžå¿ã«æ€èšãå ãã1.幎霢,ããã³çºç幎霢ãšãéå¡æ§çŽ°æ°ç®¡æ¯çã«æ¯ã¹â
¡ååæ¯ã«ãããŠé«ãåŸåãèŠãããIgEç³»åå¿ã¯â
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¡ååæ¯ã§ããäœãå€ã瀺ã,FEV1.0%,% MMFããã³% V50ã§ã¯ææã®å·®ãèŠããã3.BAL液äžå¥œäžçé »åºŠã¯,â
¡ååæ¯(55.7%),éå¡æ§çŽ°æ°ç®¡æ¯ç(74.4%)ãããã«ãããŠãé«ãå€ã瀺ããã,äž¡è
éã«ææã®å·®ã¯èŠãããªãã£ã4.äžæ¹,BAL液äžã®çµ¶å¯Ÿæ°ã§ã¯,â
¡ååæ¯ã«æ¯ã¹,éå¡æ§çŽ°æ°ç®¡æ¯çã«ãããŠ,ç·çŽ°èæ°,ãã¯ããã¡ãŒãžããã³å¥œäžçæ°ãææã®é«å€ã瀺ãã5.ãŸã,lmâãããã®çŽ°èæ°ã®æ¯èŒã§ã,éå¡æ§çŽ°æ°ç®¡æ¯çã§å¥œäžçæ°ãèæãªé«å€ã瀺ãããããã®çµæãã,ãã®2çŸæ£ã§ã¯æ°éå
奜äžçå¢å€ã¯åæ§ã«èŠããããã®ã®,ãã®æ°éççã®çšåºŠã¯æããã«éå¡æ§çŽ°æ°ç®¡æ¯çã§ããé«åºŠã§ããããšã瀺ããã
â ¡å(现æ°ç®¡æ¯éå¡)åæ¯ãšéå¡æ§çŽ°æ°ç®¡æ¯çã«ããã现æ°ç®¡æ¯é åã®ççåå¿ã®å·®
Ventilatory function and inflammatory cells in airways were compared between patients with type â
¡ (bronchiolar obstruction) asthma and those with obstructive bronchiolitis. 1. Age and age at onset were higher in patients with type â
¡ asthma than in those with obstructive bronchiolitis. IgE-mediated allergic reaction was observed in patients with type â
¡ asthma, but not in those with obstructive bronchiolitis. 2. In ventilatory function tests, all ventilatory parameters examined were lower in patients with type â
¡ asthma compared to those with obstructive bronchiolitis, and the differences were significant in FEV1.0% (p<0.001), % MMF (p<0.02), and V50 (p<0.01). 3. The proportion of BAL neutrophils was very high in type â
¡ asthma (55.7%) and obstructive bronchiolitis (74.4%), however, this was not significant. 4. Absolute numbers/BAL fluid of total cells, BAL macrophages and BAL neutrophils were significantly higher in patients with obstructive bronchiolitis than in those with type â
¡ asthma. 5. The results on absolute number/mâ of BAL cells demonstrated that number of BAL neutrophils markedly larger in patients with obstructive bronchiolitis compared to those with type â
¡ asthma. These results show that high proportion of BAL neutrophils was observed in the two respiratory diseases, however, the degree of inflammation in airways was markedly greater in obstructive bronchiolitis.â
¡ååæ¯ãšéå¡æ§çŽ°æ°ç®¡æ¯çã®èšåºçç¹åŸŽã«ã€ããŠ,ææ°æ©èœããã³æ°éççåå¿ãäžå¿ã«æ€èšãå ãã1.幎霢,ããã³çºç幎霢ãšãéå¡æ§çŽ°æ°ç®¡æ¯çã«æ¯ã¹â
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¡ååæ¯ã§ããäœãå€ã瀺ã,FEV1.0%,% MMFããã³% V50ã§ã¯ææã®å·®ãèŠããã3.BAL液äžå¥œäžçé »åºŠã¯,â
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éã«ææã®å·®ã¯èŠãããªãã£ã4.äžæ¹,BAL液äžã®çµ¶å¯Ÿæ°ã§ã¯,â
¡ååæ¯ã«æ¯ã¹,éå¡æ§çŽ°æ°ç®¡æ¯çã«ãããŠ,ç·çŽ°èæ°,ãã¯ããã¡ãŒãžããã³å¥œäžçæ°ãææã®é«å€ã瀺ãã5.ãŸã,lmâãããã®çŽ°èæ°ã®æ¯èŒã§ã,éå¡æ§çŽ°æ°ç®¡æ¯çã§å¥œäžçæ°ãèæãªé«å€ã瀺ãããããã®çµæãã,ãã®2çŸæ£ã§ã¯æ°éå
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èºæŽ»é(FVC)äœå€ã瀺ãæ°ç®¡æ¯åæ¯ã®èšåºçç¹åŸŽ
Clinical features of asthma patients with a low % FVC (<75%) were studied in relation to clinical asthma type and disease severity. 1. The value of % FVC was not related to patient age. 2. A significant association between % FVC value and clinical asthma type was found. The value of % FVC was significantly lower in subjects with type â
¡ asthma (bronchiolar obstruction) than in those with type Ia-1 and type Ia-2 (simple bronchoconstriction) (p<0.001). 3. % FVC value significantly correlated with disease severity. The value in the subjects tended to decrease as their asthma conditions were more severe. 4. The % FVC value in the subjects was improved after treatment (complex spa therapy). These results demonstrate that a significant correlation is present between low % FVC and disease severity in asthma patients with a low % FVC.% èºæŽ»éã75%以äžã®äœå€ã瀺ãæ°ç®¡æ¯åæ¯ã«ã€ããŠ,ãã®èšåºçç¹åŸŽã,èšåºç
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Bronchial asthma is often accompanied with allergic rhinitis or chronic sinusitis. Mucosal abnormalities of sinonasal cavity may influence lower respiratory responses in patients with asthma. We experienced a case of 72-year-old woman with asthma, who had dyspnea on exertion and a large volume of expectoration of more than 100mâ a day. Furthermore she had nasal symptoms (nasal obstruction and rhinorrea) with prominent post-nasal discharge. Computed tomography (CT) scans of sinonasal cavity revealed marked thickness of nasal mucosa. Although her asthma symptoms such as wheezing and dyspnea improved by administration of
bronchodialators, antiallergic agent, and beclomethason di isocyanate (BDI) accompanied with spa therapy after admission, the volume of expectoration revealed no decrease and her peak expiratory flow (PEF) didn't increase. The volume of expectoration and the PEF showed marked improvement after starting of intranasal glucocorticoid therapy. It is suggested from her clinical course that treatment with intranasal glucocorticoids is very important in asthmatic patients with mucosal abnormalities of sinonasal cavity.æ°ç®¡æ¯åæ¯çäŸã«ã¯,ã¢ã¬ã«ã®ãŒæ§éŒ»çãæ
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