20 research outputs found
(A) Disease specific survival curves of all patients (n = 102) according to the chemoradioselection.
<p>(B) Disease specific survival curves based on the CD44 v9 positivity of biopsy samples (n = 60) obtained from 30 chemoradioselected (CRS) patients and 30 non-chemoradioselected (N-CRS) patients. (C) Disease specific survival curves based on the CD44 v9 positivity of biopsy samples obtained from 30 N-CRS patients.</p
(A) Disease specific survival curves based on the CD44 v9 positivity of surgically removed samples obtained from 72 non-chemoradioselected (N-CRS) patients.
<p>(B) Diseasespecific survival curves of 30 N-CRS patients who had paired biopsy and surgically removed samples. The patients were divided into 2 groups according to their levels of CD44v9 expression before and after concurrent chemoradiotherapy.</p
Representative pictures of anti-CD44v9-antibody immunostaining.
<p>The staining intensity obtained in the basal cells of normal epithelium was used as a control (A). Tumor samples demonstrated strong (B), moderate (C), and weak (D) intensities relative to the control (A). Respective positive (E) and negative <u>(F</u>) stainings. Bar indicates 200 um.</p
Patient characteristics (<i>N</i> = 102).
<p>Patient characteristics (<i>N</i> = 102).</p
Proposed roles of CD44v9-expressing CSC and non-CSC in the chemoradioselection.
<p>(A) CD44v9-expressing non-CSCs are sensitive to CCRT. Intrinsic CD44v9-expressing CSCs (B) or CCRT-induced CD44v9-expressing CSCs (C) can survive CCRT. These CD44v9-expressing CSCs are considered to be highly invasive and metastatic. CSC, cancer stem cell; CCRT, concurrent chemoradiotherapy; CRS, chemoradioselected; and N-CRS, non-chemoradioselected.</p
Randomized Phase III Trial of Adjuvant Chemotherapy with S-1 after Curative Treatment in Patients with Squamous-Cell Carcinoma of the Head and Neck (ACTS-HNC)
<div><p>Background</p><p>We conducted a phase III study to evaluate S-1 as compared with UFT as control in patients after curative therapy for stage III, IVA, or IVB squamous-cell carcinoma of the head and neck (SCCHN).</p><p>Patients and Methods</p><p>Patients were randomly assigned to the UFT group (300 or 400 mg day<sup>-1</sup> for 1 year) or the S-1 group (80, 100, or 120 mg day<sup>-1</sup> for 1 year). The primary end point was disease-free survival (DFS). Secondary end points were relapse-free survival, overall survival (OS), and safety.</p><p>Results</p><p>A total of 526 patients were enrolled, and 505 were eligible for analysis. The 3-year DFS rate was 60.0% in the UFT group and 64.1% in the S-1 group (HR, 0.87; 95%CI, 0.66-1.16; p = 0.34). The 3-year OS rate was 75.8% and 82.9%, respectively (HR, 0.64; 95% CI, 0.44-0.94; p = 0.022). Among grade 3 or higher adverse events, the incidences of leukopenia (5.2%), neutropenia (3.6%), thrombocytopenia (2.0%), and mucositis/stomatitis (2.4%) were significantly higher in the S-1 group.</p><p>Conclusions</p><p>Although DFS did not differ significantly between the groups, OS was significantly better in the S-1 group than in the UFT group. S-1 is considered a treatment option after curative therapy for stage III, IVA, IVB SCCHN.</p><p>Trial Registration</p><p><a href="http://ClinicalTrials.gov" target="_blank">ClinicalTrials.gov</a> NCT00336947 <a href="http://clinicaltrials.gov/show/NCT00336947" target="_blank">http://clinicaltrials.gov/show/NCT00336947</a></p></div
Comparison of clinical characteristics between the chemoradiotherapy group and the other therapy group.
<p>Comparison of clinical characteristics between the chemoradiotherapy group and the other therapy group.</p
Overall survival in the CRT group.
<p>(A) OS derived from Kaplan–Meier curves. (B) HR and corresponding CI were calculated using Cox proportional hazard model. <i>P</i> values were calculated based on stratified log-rank test. Abbreviations: CI, confidence interval. HR, hazard ratio. OS, overall survival.</p
Cumulative rates of locoregional recurrence (A) and distant metastasis (B).
<p>(A) One patient with secondary cancer before locoregional recurrence was censored. (B) One patient with secondary cancer before distant metastasis was censored.</p