Pooled incidence of YMDD mutation among CHB patients untreated with antiviral drugs in each region.

<p>Pooled incidence of YMDD mutation among CHB patients untreated with antiviral drugs in each region.</p

Difference in HBV DNA copies between the patients with YMDD mutations and the patients without mutation.

<p>Difference in HBV DNA copies between the patients with YMDD mutations and the patients without mutation.</p

Difference in the incidence of YMDD mutation between lamivudine-treated patients and untreated patients.

<p>Difference in the incidence of YMDD mutation between lamivudine-treated patients and untreated patients.</p

Difference in the incidence of YMDD mutation between male and female patients.

<p>Difference in the incidence of YMDD mutation between male and female patients.</p

Difference in ALT level between the patients with YMDD mutations and the patients without mutation.

<p>Difference in ALT level between the patients with YMDD mutations and the patients without mutation.</p

Difference in the incidence of YMDD mutation between HBeAg positive and HBeAg negative patients.

<p>Difference in the incidence of YMDD mutation between HBeAg positive and HBeAg negative patients.</p

Flow diagram of the systematic literature research.

<p>Flow diagram of the systematic literature research.</p

Difference in the incidence of YMDD mutation between patients with HBV genotype B and genotype C.

<p>Difference in the incidence of YMDD mutation between patients with HBV genotype B and genotype C.</p

Genome Sequence of the Edible Cultivated Mushroom <i>Lentinula edodes</i> (Shiitake) Reveals Insights into Lignocellulose Degradation

<div><p><i>Lentinula edodes</i>, one of the most popular, edible mushroom species with a high content of proteins and polysaccharides as well as unique aroma, is widely cultivated in many Asian countries, especially in China, Japan and Korea. As a white rot fungus with lignocellulose degradation ability, <i>L</i>. <i>edodes</i> has the potential for application in the utilization of agriculture straw resources. Here, we report its 41.8-Mb genome, encoding 14,889 predicted genes. Through a phylogenetic analysis with model species of fungi, the evolutionary divergence time of <i>L</i>. <i>edodes</i> and <i>Gymnopus luxurians</i> was estimated to be 39 MYA. The carbohydrate-active enzyme genes in <i>L</i>. <i>edodes</i> were compared with those of the other 25 fungal species, and 101 lignocellulolytic enzymes were identified in <i>L</i>. <i>edodes</i>, similar to other white rot fungi. Transcriptome analysis showed that the expression of genes encoding two cellulases and 16 transcription factor was up-regulated when mycelia were cultivated for 120 minutes in cellulose medium versus glucose medium. Our results will foster a better understanding of the molecular mechanism of lignocellulose degradation and provide the basis for partial replacement of wood sawdust with agricultural wastes in <i>L</i>. <i>edodes</i> cultivation.</p></div

RNA-Seq data of CAZyme genes and transcription factor genes of <i>L</i>. <i>edodes</i>.

<p>RNA-Seq data of CAZyme genes and transcription factor genes of <i>L</i>. <i>edodes</i>.</p