2-(1H-Pyrrolo­[2,3-b]pyridin-2-yl)pyridine

In the title compound, C12H9N3, the dihedral angle between the pyridine and aza­indole rings is 6.20 (2)°. In the crystal, pairs of N—H⋯N hydrogen bonds link mol­ecules into inversion dimers

3,4-Dinitro-2,5-bis­[4-(trifluoro­meth­yl)phen­yl]thio­phene

The title compound, C18H8F6N2O4S, is a precursor for the production of low-band-gap conjugated polymers. In the crystal structure, the dihedral angles between the thio­phene and benzene rings are 35.90 (8) and 61.94 (8)°, and that between the two benzene rings is 40.18 (8)°. The two nitro groups are twisted with respect to the thio­phene ring, the dihedral angles being 53.66 (10) and 31.63 (10)°. Weak inter­molecular C—H⋯O hydrogen bonding helps to stabilize the crystal structure

Profiling time course expression of virus genes---an illustration of Bayesian inference under shape restrictions

There have been several studies of the genome-wide temporal transcriptional program of viruses, based on microarray experiments, which are generally useful in the construction of gene regulation network. It seems that biological interpretations in these studies are directly based on the normalized data and some crude statistics, which provide rough estimates of limited features of the profile and may incur biases. This paper introduces a hierarchical Bayesian shape restricted regression method for making inference on the time course expression of virus genes. Estimates of many salient features of the expression profile like onset time, inflection point, maximum value, time to maximum value, area under curve, etc. can be obtained immediately by this method. Applying this method to a baculovirus microarray time course expression data set, we indicate that many biological questions can be formulated quantitatively and we are able to offer insights into the baculovirus biology.Comment: Published in at http://dx.doi.org/10.1214/09-AOAS258 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

9-Ethyl-3-(imidazo[1,2-a]pyrimidin-3-yl)-9H-carbazole

The title compound, C20H16N4, is a precursor for the production of electron-transporting and -emitting materials. The bond lengths and angles in this compound are normal. In the crystal structure, there are no significant hydrogen-bonding inter­actions or π–π stacking inter­actions between mol­ecules

[4-(1-Benzofuran-2-yl)phen­yl]diphenyl­amine

The asymmetric unit of the title compound, C26H19NO, contains two mol­ecules. The dihedral angles between the benzofuran and benzene rings are 5.09 (8), 59.02 (8) and 67.74 (8)° in one mol­ecule and 18.70 (8), 52.78 (8) and 41.74 (8)° in the other. Weak inter­molecular C—H⋯π inter­actions help to stabilize the molecular structure

Early-cleavage is a reliable predictor for embryo implantation in the GnRH agonist protocols but not in the GnRH antagonist protocols

<p>Abstract</p> <p>Background</p> <p>To test if early-cleavage was a strong predictor of pregnancy in patients receiving either a GnRH agonist long protocol or a GnRH antagonist protocol for in-vitro fertilization treatment (IVF) and intracytoplasmic sperm injection (ICSI).</p> <p>Methods</p> <p>This retrospective study included 534 patients undergoing a fresh cycle of oocyte retrieval and the day-3 embryo transfer (from 22 to 46 years old). Of the 534 patients treated, 331 received a GnRH agonist long stimulation protocol (GnRH agonist group) for ovarian stimulation and 203 patients received a GnRH antagonist protocol (GnRH antagonist group). In each group, patients who had at least one early-cleavage embryo transferred were designated as the 'early-cleavage' subgroup. Patients who had no early-cleavage embryos transferred were designated as the 'late-cleavage' subgroup.</p> <p>Results</p> <p>The early cleavage rate was significantly lower in the GnRH antagonist group compared with that in the GnRH agonist group (IVF cycles: 34% versus 20%; ICSI cycles: 50% versus 37.8%, respectively, P < 0.0001). In the GnRH agonist group, the pregnancy rates were significantly higher in the early-cleavage subgroup than those in the late-cleavage subgroup (53.7% vs 33.9%, <it>P </it>< 0.0001). In the GnRH antagonist group, the pregnancy rates were not significantly different between the early-cleavage and late-cleavage subgroups (45.9% vs 43.8%, P > 0.05).</p> <p>Conclusion</p> <p>Early cleavage of zygote is not a reliable predictor for embryo implantation potential in using the GnRH antagonist protocol. Furthermore, the implantation rates between the GnRH agonist and GnRH antagonist groups were comparable.</p

Bis(morpholin-4-ium) tetra­chlorido­cobalt(II)

The title compound, (C4H10NO)2[CoCl4], is an ionic compound consisting of two protonated tetra­hydro-1,4-oxazine (morpholine) cations and a [CoCl4]2− dianion. The CoII ion is in a tetra­hedral coordination geometry. The cations exhibit chair-shaped conformations. A three-dimensional supra­molecular architecture is formed through N—H⋯Cl and C—H⋯Cl hydrogen bonds between the dianions and the cations

7-Hy­droxy­indan-1-one

In the title compound, C9H8O2, an intra­molecular O—H⋯O hydrogen bond generates an S(6) ring. The dihedral angle between the mean plane of the S(6) ring and the benzene ring is 1.89 (2)°. In the crystal, inversion-related mol­ecules are linked by pairs of O—H⋯O hydrogen bonds, forming a cyclic dimers with R 2 2(12) graph-set motif. Weak inter­molecular C—H⋯Ocarbon­yl and C—H⋯Ohy­droxy hydrogen bonds link the dimers into chains along [010], generating two C(6) motifs that overlap three C atoms, forming R 2 2(8) ring motifs

Synthesis and characterization of new fluorescent two-photon absorption chromophores{

A series of dipolar and quadrupolar type two-photon absorption (TPA) compounds has been synthesized and TPA cross sections (s) were measured by Ti:sapphire femtosecond laser excitation fluorescence (l = 800 nm). Among them, the compound ) can be achieved. One quadrupolar molecule (13) possessing an arylamine donor and a pyridazine acceptor has both a high s value (1442 GM) and s/MW (1.97 GM/g)