46 research outputs found

    Quantum metrology enhanced by the XYXY spin interaction in a generalized Tavis-Cummings model

    Full text link
    Quantum metrology is recognized for its capability to offer high-precision estimation by utilizing quantum resources, such as quantum entanglement. Here, we propose a generalized Tavis-Cummings model by introducing the XYXY spin interaction to explore the impact of the many-body effect on estimation precision, quantified by the quantum Fisher information (QFI). By deriving the effective description of our model, we establish a closed relationship between the QFI and the spin fluctuation induced by the XYXY spin interaction. Based on this exact relation, we emphasize the indispensable role of the spin anisotropy in achieving the Heisenberg-scaling precision for estimating a weak magnetic field. Furthermore, we observe that the estimation precision can be enhanced by increasing the strength of the spin anisotropy. We also reveal a clear scaling transition of the QFI in the Tavis-Cummings model with the reduced Ising interaction. Our results contribute to the enrichment of metrology theory by considering many-body effects, and they also present an alternative approach to improving the estimation precision by harnessing the power provided by many-body quantum phases

    Exosomes derived from differentiated human ADMSC with the Schwann cell phenotype modulate peripheral nerve-related cellular functions

    Get PDF
    Peripheral nerve regeneration remains a significant clinical challenge due to the unsatisfactory functional recovery and public health burden. Exosomes, especially those derived from mesenchymal stem cells (MSCs), are promising as potential cell-free therapeutics and gene therapy vehicles for promoting neural regeneration. In this study, we reported the differentiation of human adipose derived MSCs (hADMSCs) towards the Schwann cell (SC) phenotype (hADMSC-SCs) and then isolated exosomes from hADMSCs with and without differentiation (i.e., dExo vs uExo). We assessed and compared the effects of uExo and dExo on antioxidative, angiogenic, antiinflammatory, and axon growth promoting properties by using various peripheral nerve-related cells. Our results demonstrated that hADMSC-SCs secreted more neurotrophic factors and other growth factors, compared to hADMSCs without differentiation. The dExo isolated from hADMSC-SCs protected rat SCs from oxidative stress and enhanced HUVEC migration and angiogenesis. Compared to uExo, dExo also had improved performances in downregulating pro-inflammatory gene expressions and cytokine secretions and promoting axonal growth of sensory neurons differentiated from human induced pluripotent stem cells. Furthermore, microRNA (miRNA) sequencing analysis revealed that exosomes and their parent cells shared some similarities in their miRNA profiles and exosomes displayed a distinct miRNA signature. Many more miRNAs were identified in dExo than in uExo. Several upregulated miRNAs, like miRNA-132-3p and miRNA-199b-5p, were highly related to neuroprotection, anti-inflammation, and angiogenesis. The dExo can effectively modulate various peripheral nerverelated cellular functions and is promising for cell-free biological therapeutics to enhance neural regeneration

    Factors affecting the early establishment of neonatal intestinal flora and its intervention measures

    Get PDF
    In recent years, it has become evident that early-life intestinal flora plays a pivotal role in determining human health. Consequently, it is imperative to explore the establishment of neonatal intestinal flora and its influencing factors. Early neonatal intestinal flora is influenced by a multitude of factors, including maternal and infant-related factors, as well as external environment. This review summarizes the colonization mechanism of intestinal flora in the early life of newborns and discussed their influence on the establishment of neonatal intestinal flora, taking into account factors such as delivery mode, gestational age and feeding mode. Additionally, this review delves into the natural or artificial reconstruction of intestinal flora colonization defects in infants born via cesarean section and premature infants, with the goal of establishing a theoretical foundation for preventing and treating issues related to neonatal intestinal flora colonization and associated diseases

    The Effect of Initial Structure on Phase Transformation in Continuous Heating of a TA15 Titanium Alloy

    No full text
    The effect of initial structure on phase evolution in continuous heating of a near-α TA15 titanium alloy (Ti-6Al-2Zr-1Mo-1V) was experimentally investigated. To this end; three microstructures were obtained by multiple heat treatment: I-bimodal structure with 50% equaixed α, II-bimodal structure with 15% equiaxed α, III-trimodal structure with 18% equiaxed α and 25% lamellar α. Differential scanning calorimetry (DSC), dilatometry and quantitative metallography were carried out on specimens with the three initial structures at heating rates from 5 to 40 °C/min. The transformation kinetics was modeled with the Johnson–Mehl–Avrami (JMA) approach under non-isothermal condition. It was found that there exists a four-stage transformation for microstructures I and III. The secondary and third stages overlap for microstructure II. The four stages of phase transformation overlap with increasing heating rate. In the presence of α laths, the phase transformation kinetics is affected by the composition difference between lamellar α and primary equiaxed α. Phase transformation is controlled by the growth of existing large β phase

    Experimental study on unconfined compressive strength of expansive soil improved by lignin and cement

    No full text
    Aiming at the question of improvement expansive soil in Nanyang area, the composite improvement method of lignin and cement was adopted. Based on the unconfined compressive strength test, the variation law of unconfined compressive strength of improved expansive soil with different lignin content, different compaction degree and different curing age was studied. The test results show that the composite of lignin and cement can effectively improve the unconfined compressive strength of expansive soil. The unconfined compressive strength of L-C (lignin and cement) improved expansive soil reaches the maximum when the cement content is fixed at 4% and the lignin content is 1%. The unconfined compressive strength of L-C improved soil increases with the increase of compaction degree and curing age, and the strength growth mainly concentrated in the first 7 days of curing age. From the point of improvement mechanism, the hydration and gelation reaction of cement occur in expansive soil, and gel material with higher strength is formed to enhance the strength of expansive soil. The appropriate amount of lignin can fill the pores between soil particles and make the connection between soil particles more closely, so as to improve the strength of expansive soil

    Synergistic Effects of Graphene and Ammonium Polyphosphate Modified with Vinyltrimethoxysilane on the Properties of High-Impact Polystyrene Composites

    No full text
    Ammonium polyphosphate (APP) was modified with a silane coupling agent (vinyltrimethoxysilane, Si-171), and then the synergistic flame retarding effect of graphene and surface-modified APP (APP@Si-171) on high-impact polystyrene (HIPS) was investigated. Surface modification and thermal stability characterization of APP were analyzed by Fourier transform infrared spectroscopy (FTIR), energy dispersive spectrometer (EDS), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). The results showed that surface-modified APP (APP@Si-171) exhibited significantly better dispersion and less agglomeration tendencies compared with pure APP. A series of target HIPS composites containing different mass fractions of the two flame retardants were prepared by melt blending. TGA and cone calorimeter tests (CCT) were conducted to quantitatively investigate the thermal and flammability properties of the composites, respectively. Results from TGA and CCT demonstrated that the addition of the flame retardants delayed the onset and peak temperatures in differential thermogravimetry (DTG) curves and weakened the peak heat release rate (PHRR) and total heat release (THR). Moreover, the synergistic effect index (SE) was employed to quantify the synergistic behavior between the two fillers, and the results showed that APP@Si-171 and graphene had a synergistic effect on improving the thermal stability and flame retardancy of HIPS
    corecore