Analysis of Failure Propagation in Cyber-Physical Power Systems Based on an Epidemic Model

From the perspective of propagation dynamics in complex networks, failure propagation in cyber-physical power systems is analogous to the spread of diseases; subsequently, the cyber nodes and power nodes are regarded as individuals in each of their groups. In this study, a two-layer interdependent network model of the cyber-physical power system is proposed, where each subnetwork adopts the Susceptible-Infected-Susceptible (SIS) epidemic-spreading model. On this basis, we construct a failure cooperation propagation model of cyber-physical power systems. Furthermore, we introduce the node protection mechanism to ensure the normal operation of key nodes. The generated scale-free cyber network and IEEE118-bus power system are used for simulation to analyze the influence of the coupling effect between them on the final failure scale

Feasibility analysis of hybrid energy generation systems for desert highway service areas: a case study in northern Xinjiang, China

Highways consume a significant amount of electrical energy annually, especially in remote desert regions where the cost of electricity is high. This research explores the utilization of natural resources along desert highways to establish hybrid energy generation systems for service areas. Three service areas along the desert highway in northern Xinjiang, China, serve as case studies. To assess the feasibility of hybrid energy generation systems in these service areas, meteorological data for the three locations were obtained from the NASA platform. The HOMER Pro software was employed for technical, economic, and environmental analyses of the systems. The results indicate the feasibility of Photovoltaic (PV)/Wind/Battery hybrid energy systems in the Huanghuagou, Kelameili, and Wujiaqu service areas. The application of these hybrid energy generation systems across the three service areas could provide 3,349,557 kWh of electrical energy annually for the desert highway. Sensitivity analysis reveals that the Net Present Cost (NPC) and Cost of Energy (COE) values decrease with increasing radiation levels, while NPC shows an increasing trend with growing load demand, and COE exhibits a decreasing trend. Among the three regions, Wujiaqu demonstrates the highest economic viability, with a COE of $0.34/kWh and an NPC of$3,141,641/kWh. Furthermore, Wujiaqu exhibits the lowest environmental impact, with CO2 emissions of 198,387 kg/yr, SO2 emissions of 493 kg/yr, and NOx emissions of 1,711 kg/yr

MicroRNA-145 Regulates Human Corneal Epithelial Differentiation

Epigenetic factors, such as microRNAs, are important regulators in the self-renewal and differentiation of stem cells and progenies. Here we investigated the microRNAs expressed in human limbal-peripheral corneal (LPC) epithelia containing corneal epithelial progenitor cells (CEPCs) and early transit amplifying cells, and their role in corneal epithelium.Human LPC epithelia was extracted for small RNAs or dissociated for CEPC culture. By Agilent Human microRNA Microarray V2 platform and GeneSpring GX11.0 analysis, we found differential expression of 18 microRNAs against central corneal (CC) epithelia, which were devoid of CEPCs. Among them, miR-184 was up-regulated in CC epithelia, similar to reported finding. Cluster miR-143/145 was expressed strongly in LPC but weakly in CC epithelia (P = 0.0004, Mann-Whitney U-test). This was validated by quantitative polymerase chain reaction (qPCR). Locked nucleic acid-based in situ hybridization on corneal rim cryosections showed miR-143/145 presence localized to the parabasal cells of limbal epithelium but negligible in basal and superficial epithelia. With holoclone forming ability, CEPCs transfected with lentiviral plasmid containing mature miR-145 sequence gave rise to defective epithelium in organotypic culture and had increased cytokeratin-3/12 and connexin-43 expressions and decreased ABCG2 and p63 compared with cells transfected with scrambled sequences. Global gene expression was analyzed using Agilent Whole Human Genome Oligo Microarray and GeneSpring GX11.0. With a 5-fold difference compared to cells with scrambled sequences, miR-145 up-regulated 324 genes (containing genes for immune response) and down-regulated 277 genes (containing genes for epithelial development and stem cell maintenance). As validated by qPCR and luciferase reporter assay, our results showed miR-145 suppressed integrin β8 (ITGB8) expression in both human corneal epithelial cells and primary CEPCs.We found expression of miR-143/145 cluster in human corneal epithelium. Our results also showed that miR-145 regulated the corneal epithelium formation and maintenance of epithelial integrity, via ITGB8 targeting

Real-time Monitoring for the Next Core-Collapse Supernova in JUNO

Core-collapse supernova (CCSN) is one of the most energetic astrophysical events in the Universe. The early and prompt detection of neutrinos before (pre-SN) and during the SN burst is a unique opportunity to realize the multi-messenger observation of the CCSN events. In this work, we describe the monitoring concept and present the sensitivity of the system to the pre-SN and SN neutrinos at the Jiangmen Underground Neutrino Observatory (JUNO), which is a 20 kton liquid scintillator detector under construction in South China. The real-time monitoring system is designed with both the prompt monitors on the electronic board and online monitors at the data acquisition stage, in order to ensure both the alert speed and alert coverage of progenitor stars. By assuming a false alert rate of 1 per year, this monitoring system can be sensitive to the pre-SN neutrinos up to the distance of about 1.6 (0.9) kpc and SN neutrinos up to about 370 (360) kpc for a progenitor mass of 30$M_{\odot}$ for the case of normal (inverted) mass ordering. The pointing ability of the CCSN is evaluated by using the accumulated event anisotropy of the inverse beta decay interactions from pre-SN or SN neutrinos, which, along with the early alert, can play important roles for the followup multi-messenger observations of the next Galactic or nearby extragalactic CCSN.Comment: 24 pages, 9 figure

A Novel High-Frequency Voltage Standing-Wave Ratio-Based Grounding Electrode Line Fault Supervision in Ultra-High Voltage DC Transmission Systems

In order to improve the fault monitoring performance of grounding electrode lines in ultra-high voltage DC (UHVDC) transmission systems, a novel fault monitoring approach based on the high-frequency voltage standing-wave ratio (VSWR) is proposed in this paper. The VSWR is defined considering a lossless transmission line, and the characteristics of the VSWR under different conditions are analyzed. It is shown that the VSWR equals 1 when the terminal resistance completely matches the characteristic impedance of the line, and when a short circuit fault occurs on the grounding electrode line, the VSWR will be greater than 1. The VSWR will approach positive infinity under metallic earth fault conditions, whereas the VSWR in non-metallic earth faults will be smaller. Based on these analytical results, a fault supervision criterion is formulated. The effectiveness of the proposed VSWR-based fault supervision technique is verified with a typical UHVDC project established in Power Systems Computer Aided Design/Electromagnetic Transients including DC(PSCAD/EMTDC). Simulation results indicate that the proposed strategy can reliably identify the grounding electrode line fault and has strong anti-fault resistance capability

Design, Synthesis, Antifungal Activity, and 3D-QSAR Study of Novel Quinoxaline-2-Oxyacetate Hydrazide

Plant pathogenic fungi pose a major threat to global food security, ecosystem services, and human livelihoods. Effective and broad-spectrum fungicides are needed to combat these pathogens. In this study, a novel antifungal 2-oxyacetate hydrazide quinoxaline scaffold as a simple analogue was designed and synthesized. Their antifungal activities were evaluated against Botrytis cinerea (B. cinerea), Altemaria solani (A. solani), Gibberella zeae (G. zeae), Rhizoctonia solani (R. solani), Colletotrichum orbiculare (C. orbiculare), and Alternaria alternata (A. alternata). These results demonstrated that most compounds exhibited remarkable inhibitory activities and possessed better efficacy than ridylbacterin, such as compound 15 (EC50 = 0.87 μg/mL against G. zeae, EC50 = 1.01 μg/mL against C. orbiculare) and compound 1 (EC50 = 1.54 μg/mL against A. alternata, EC50 = 0.20 μg/mL against R. solani). The 3D-QSAR analysis of quinoxaline-2-oxyacetate hydrazide derivatives has provided new insights into the design and optimization of novel antifungal drug molecules based on quinoxaline

A Novel High-Frequency Voltage Standing-Wave Ratio-Based Grounding Electrode Line Fault Supervision in Ultra-High Voltage DC Transmission Systems

In order to improve the fault monitoring performance of grounding electrode lines in ultra-high voltage DC (UHVDC) transmission systems, a novel fault monitoring approach based on the high-frequency voltage standing-wave ratio (VSWR) is proposed in this paper. The VSWR is defined considering a lossless transmission line, and the characteristics of the VSWR under different conditions are analyzed. It is shown that the VSWR equals 1 when the terminal resistance completely matches the characteristic impedance of the line, and when a short circuit fault occurs on the grounding electrode line, the VSWR will be greater than 1. The VSWR will approach positive infinity under metallic earth fault conditions, whereas the VSWR in non-metallic earth faults will be smaller. Based on these analytical results, a fault supervision criterion is formulated. The effectiveness of the proposed VSWR-based fault supervision technique is verified with a typical UHVDC project established in Power Systems Computer Aided Design/Electromagnetic Transients including DC(PSCAD/EMTDC). Simulation results indicate that the proposed strategy can reliably identify the grounding electrode line fault and has strong anti-fault resistance capability

Large-Scale Construction Waste Mountain-Mounding Technology Based on the Project in Meibei Lake Scenic Area

In the backdrop of China’s rapid economic growth and urbanization, the surge in construction waste poses mounting disposal challenges. This study primarily focuses on in-depth research and exploration of construction waste recycling technologies. By repurposing towering heaps of construction debris into artificial landscapes, it achieves resource reutilization and waste reduction, bearing profound significance for environmental protection, and resource utilization. Taking the Xi’an Meibei Lake Scenic Area construction waste embankment project as a case study, experiments on the physical properties of soil-construction waste mixtures were conducted. A three-dimensional computational model of the site was established, and typical cross-sections were selected for the slope stability calculations and analysis. This was coupled with on-site measurements to validate the practicality and effectiveness of the technology. The successful execution of the project has demonstrated the reliability of this technology, offering significant potential for widespread application and serving as a crucial reference for the similar projects