Synthesis of α-arylalkylferrocenes through cesium fluoride-promoted coupling of arylboronic acids with <i>N</i>-tosylhydrazones

<p>A cesium fluoride-promoted reductive coupling reaction of acylferrocene tosylhydrazones with arylboronic acids has been developed, producing highly substituted α-arylalkylferrocenes in moderate to excellent yields. The reaction employs anionic fluorine to facilitate the cleavage of C–B bond. The developed methodology demonstrates a wide substrate scope and high functional groups tolerance. Moreover, the α-arylalkylferrocenes compounds were also obtained on a multi-gram scale.</p