Relationship between PD-L1 expression and clinical characteristics in patients with breast invasive ductal carcinoma

To evaluate the expression of PD-L1 (programmed death 1 ligand 1, PD-L1) and its clinical significance in breast invasive ductal carcinoma

Process for forming self-assembled polymer layers on a metal surface

A new process is provided for the formation of self assembled polymer layers on a pretreated metallic substrate. The polymers used for forming such self assembled layers are homo, co and terpolymers of styrene and styrenic derivatives containing reactive groups selected from the group consisting of hydroxy, thiol, acetoxy, thioacetoxy, thiocyanate, thiolmethyl, thioacetoxymethyl, carboxy, and mixtures thereof. The pretreated metallic substrate having zerovalent metal or metal oxide surface is contacted with said polymeric solution or dispersion to form self assembled polymer layers on such a metallic substrate.U

Co and terpolymers of styrenic monomers having reactive functional groups

Present invention provides a new class of polymeric materials having utility in the formation of self assembled polymer layers on a pretreated metallic substrate. The polymeric materials are copolymers and terpolymers of styrene and styrenic derivatives containing a reactive group selected from the group consisting of hydroxy, thiol acetoxy, thioacetoxy, thiocyanate, thiolmethyl, thioacetoxymethyl, carboxy, and mixtures thereof.U

Co and terpolymers of styrenic monomers having reactive functional groups

Present invention provides a new class of polymeric materials having utility in the formation of self assembled polymer layers on a pretreated metallic substrate. The polymeric materials are copolymers and terpolymers of styrene and styrenic derivatives containing a reactive group selected from the group consisting of hydroxy, thiol acetoxy, thioacetoxy, thiocyanate, thiolmethyl, thioacetoxymethyl, carboxy, and mixtures thereof.U

Process for forming self-assembled polymer layers on a metal surface

A new process is provided for the formation of self assembled polymer layers on a pretreated metallic substrate. The polymers used for forming such self assembled layers are homo, co and terpolymers of styrene and styrenic derivatives containing reactive groups selected from the group consisting of hydroxy, thiol, acetoxy, thioacetoxy, thiocyanate, thiolmethyl, thioacetoxymethyl, carboxy, and mixtures thereof. The pretreated metallic substrate having zerovalent metal or metal oxide surface is contacted with said polymeric solution or dispersion to form self assembled polymer layers on such a metallic substrate.U

Process for forming self-assembled polymer layers on a metal surface

A new process is provided for the formation of self assembled polymer layers on a pretreated metallic substrate. The polymers used for forming such self assembled layers are homo, co and terpolymers of styrene and styrenic derivatives containing reactive groups selected from the group consisting of hydroxy, thiol, acetoxy, thioacetoxy, thiocyanate, thiolmethyl, thioacetoxymethyl, carboxy, and mixtures thereof. The pretreated metallic substrate having zerovalent metal or metal oxide surface is contacted with said polymeric solution or dispersion to form self assembled polymer layers on such a metallic substrate.U

Process for forming self-assembled polymer layers on a metal surface

A new process is provided for the formation of self assembled polymer layers on a pretreated metallic substrate. The polymers used for forming such self assembled layers are homo, co and terpolymers of styrene and styrenic derivatives containing reactive groups selected from the group consisting of hydroxy, thiol, acetoxy, thioacetoxy, thiocyanate, thiolmethyl, thioacetoxymethyl, carboxy, and mixtures thereof. The pretreated metallic substrate having zerovalent metal or metal oxide surface is contacted with said polymeric solution or dispersion to form self assembled polymer layers on such a metallic substrate.U

Determination of Vancomycin in Human Serum by Cyclodextrin-Micellar Electrokinetic Capillary Chromatography (CD-MEKC) and Application for PDAP Patients

A simple and sensitive cyclodextrin-micellar electrokinetic capillary chromatography (CD-MEKC) method with UV detection was developed and validated for the determination of vancomycin (VCM) in serum. The separation was achieved in 14 min at 25 °C with a fused-silica capillary column of 40.2 cm × 75 μm i.d. (effective length 30.2 cm) and a run buffer containing 25 mM borate buffer with 50 mM sodium dodecylsulfonate (SDS) (pH 9.5) and 2% sulfobutyl-β-cyclodextrin (sulfobutyl-β-CD). Under optimal conditions for biological samples, good separations with high efficiency and short analysis time were achieved. Several parameters affecting the drug separation from biological matrices were studied, including buffer types, concentrations, and pHs. The methods were validated over the range of 0.9998–99.98 µg/mL. Calibration curves of VCM also showed good linearity (r2 > 0.999). Intra- and interday precisions (relative standard deviation, RSD) were less than 5.80% and 7.38%, and lower limit of quantification (LLOQ) were lower than 1.0 μg/mL. The mean recoveries ranged between 84.03% and 91.69%. The method was successfully applied for monitoring VCM concentrations in serum of patients with peritoneal dialysis-associated peritonitis (PDAP). The assay should be applicable to pharmacokinetic studies and routine therapeutic drug monitoring of this drug in serum