Warm molecular gas in galaxy-galaxy merger NGC6090

We present observations of the CO 2-1 and 3-2 transitions toward the merging galaxies of NGC6090 with the Submillimeter Array (SMA) (The Submillimeter Array (SMA) is a joint project between the Smithsonian Astrophysical Observatory and the Academia Sinica Institute of Astronomy and Astrophysics, and is funded by the Smithsonian Institution and the Academia Sinica.). The high resolution CO data reveal three gas concentrations. The main component is peaking in the overlap region between the two galaxies, where the near-IR a nd radio continuum emission are weak. The CO 2-1 emission from the face-on galaxy NGC6090E is somewhat stronger than that from the edge-o n galaxy NGC6090W. The CO 3-2 emission peaks in the overlap region, similar to the CO 2-1 emission . More than 50% of the CO 3-2 emission arises from the 2$''$ (1.2 kpc) area of the overlap region. There appears to be CO 3-2 emission toward the nuclear region and the north-west arm of NGC6090E, while no CO 3-2 emission is detected toward NGC6090W. Unlike the CO gas, most of the radio continuum emission comes from NGC6090E. The strong CO emission, together with the weak radio continuum emission, suggests that star formation in the overlap region has not proceeded long enoug h to produce significant numbers of supernovae which would be detectable due to their radio continuum emission.Comment: Accepted by ApJ

TIGIT regulates CD4+ T cell immunity against polymicrobial sepsis

BackgroundSepsis is one of the major causes of death and increased health care burden in modern intensive care units. Immune checkpoints have been prompted to be key modulators of T cell activation, T cell tolerance and T cell exhaustion. This study was designed to investigate the role of the negative immune checkpoint, T cell immunoglobulin and ITIM domain (TIGIT), in the early stage of sepsis.MethodAn experimental murine model of sepsis was developed by cecal ligation and puncture (CLP). TIGIT and CD155 expression in splenocytes at different time points were assessed using flow cytometry. And the phenotypes of TIGIT-deficient (TIGIT-/-) and wild-type (WT) mice were evaluated to explore the engagement of TIGIT in the acute phase of sepsis. In addition, the characteristics were also evaluated in the WT septic mice pretreated with anti-TIGIT antibody. TIGIT and CD155 expression in tissues was measured using real-time quantitative PCR and immunofluorescence staining. Proliferation and effector function of splenic immune cells were evaluated by flow cytometry. Clinical severity and tissue injury were scored to evaluate the function of TIGIT on sepsis. Additionally, tissue injury biomarkers in peripheral blood, as well as bacterial load in peritoneal lavage fluid and liver were also measured.ResultsThe expression of TIGIT in splenic T cells and NK cells was significantly elevated at 24 hours post CLP.TIGIT and CD155 mRNA levels were upregulated in sepsis-involved organs when mice were challenged with CLP. In CLP-induced sepsis, CD4+ T cells from TIGIT-/- mice shown increased proliferation potency and cytokine production when compared with that from WT mice. Meanwhile, innate immune system was mobilized in TIGIT-/- mice as indicated by increased proportion of neutrophils and macrophages with potent effector function. In addition, tissue injury and bacteria burden in the peritoneal cavity and liver was reduced in TIGIT-/- mice with CLP induced sepsis. Similar results were observed in mice treated with anti-TIGIT antibody.ConclusionTIGIT modulates CD4+ T cell response against polymicrobial sepsis, suggesting that TIGIT could serve as a potential therapeutic target for sepsis

Inhomogeneous Microstructure Evolution of 6061 Aluminum Alloyat High Rotating Speed Submerged Friction Stir Processing

An inhomogeneous microstructure induced by high rotating speed submerged friction stir processing (HRS-SFSP) on 6061 aluminum alloy was researched in detail.The microstructures of the aluminum alloy processing zone were characterized by electron backscattered diffraction (EBSD) and transmission electron microscope (TEM) qualitatively and quantitatively.The results show that the recrystallization proportion in the inhomogeneous structure of the processing zone is 14.3%, 37.8% and 35.9%, respectively. Different degrees of grain deformation can affect the dislocation and lead to the formation of a plastic–elastic interface. At the same time, the second-phase particles in the processing zone were inhomogeneity and relatively, which further promotes the plastic–elastic interface effect. The plastic–elastic interface can significantly improve the strength of aluminum alloy, whileat the same time, rely on recrystallized grains to provide enough plasticity. When the rotation speed was 3600 r/min, the strength and ductility of the aluminum alloy after HRS-SFSP were increased by 48.7% and 10.2% respectively compared with that of BM. In all, the plastic–elastic interface can be formed by using high rotating speed submerged friction stir processing, and the strength-ductility synergy of aluminum alloy can be realized at the plastic–elastic interface

DataSheet_1_TIGIT regulates CD4+ T cell immunity against polymicrobial sepsis.docx

BackgroundSepsis is one of the major causes of death and increased health care burden in modern intensive care units. Immune checkpoints have been prompted to be key modulators of T cell activation, T cell tolerance and T cell exhaustion. This study was designed to investigate the role of the negative immune checkpoint, T cell immunoglobulin and ITIM domain (TIGIT), in the early stage of sepsis.MethodAn experimental murine model of sepsis was developed by cecal ligation and puncture (CLP). TIGIT and CD155 expression in splenocytes at different time points were assessed using flow cytometry. And the phenotypes of TIGIT-deficient (TIGIT-/-) and wild-type (WT) mice were evaluated to explore the engagement of TIGIT in the acute phase of sepsis. In addition, the characteristics were also evaluated in the WT septic mice pretreated with anti-TIGIT antibody. TIGIT and CD155 expression in tissues was measured using real-time quantitative PCR and immunofluorescence staining. Proliferation and effector function of splenic immune cells were evaluated by flow cytometry. Clinical severity and tissue injury were scored to evaluate the function of TIGIT on sepsis. Additionally, tissue injury biomarkers in peripheral blood, as well as bacterial load in peritoneal lavage fluid and liver were also measured.ResultsThe expression of TIGIT in splenic T cells and NK cells was significantly elevated at 24 hours post CLP.TIGIT and CD155 mRNA levels were upregulated in sepsis-involved organs when mice were challenged with CLP. In CLP-induced sepsis, CD4+ T cells from TIGIT-/- mice shown increased proliferation potency and cytokine production when compared with that from WT mice. Meanwhile, innate immune system was mobilized in TIGIT-/- mice as indicated by increased proportion of neutrophils and macrophages with potent effector function. In addition, tissue injury and bacteria burden in the peritoneal cavity and liver was reduced in TIGIT-/- mice with CLP induced sepsis. Similar results were observed in mice treated with anti-TIGIT antibody.ConclusionTIGIT modulates CD4+ T cell response against polymicrobial sepsis, suggesting that TIGIT could serve as a potential therapeutic target for sepsis.</p

Effect of acupoint hot compress on postpartum urinary retention after vaginal delivery: a randomized clinical trial

Importance: acupoint hot compress during the early postpartum period may benefit patients after a vaginal delivery, but the evidence of this effect is limited.Objective: to assess whether acupoint hot compress involving the abdominal, lumbosacral, and plantar regions could reduce the incidence of postpartum urinary retention, relieve postpartum uterine contraction pain, prevent emotional disorders, and promote lactation.Design, setting, and participants: this multicenter randomized clinical trial was conducted at 12 hospitals in China. Pregnant patients were screened for eligibility (n = 13 949) and enrolled after vaginal delivery (n = 1200) between January 17 and August 15, 2021; data collection was completed on August 18, 2021. After vaginal delivery, these participants were randomized 1:1 to either the intervention group or control group. Statistical analysis was based on per-protocol population.Interventions: participants in the control group received routine postpartum care. Participants in the intervention group received routine postpartum care plus 3 sessions of a 4-hour acupoint hot compress involving the abdominal, lumbosacral, and plantar regions within 30 minutes, 24 hours, and 48 hours after delivery.Main outcomes and measures: the primary outcome was the incidence of postpartum urinary retention, defined as the first urination occurring more than 6.5 hours after delivery and/or use of an indwelling catheter within 72 hours after delivery. The secondary outcomes were postpartum uterine contraction pain intensity (assessed with the visual analog scale [VAS]), depressive symptoms (assessed with the Edinburgh Postnatal Depression Scale), and lactation conditions (including lactation initiation time, breastfeeding milk volume, feeding mood and times, and newborn weight).Results: of the 1200 participants randomized, 1085 completed the study (537 in the intervention group and 548 in the control group, with a median [IQR] age of 26.0 [24.0-29.0] years). Participants in the intervention group compared with the control group had significantly decreased incidence of postpartum urinary retention (relative risk [RR], 0.58; 95% CI, 0.35-0.98; P = .03); improved postpartum uterine contraction pain when measured at 6.5 hours (median [IQR] VAS score, 1 [1-2] vs 2 [1-2]; P &lt; .001), 28.5 hours (median [IQR] VAS score, 1 [0-1] vs 1 [1-2]; P &lt; .001), 52.5 hours (median [IQR] VAS score, 1 [0-1] vs 1 [0-1]; P &lt; .001), and 76.5 hours (median [IQR] VAS score, 0 [0-1] vs 0 [0-1]; P = .01) after delivery; reduced depressive symptoms (RR, 0.73; 95% CI, 0.54-0.98; P = .01); and increased breastfeeding milk volume measured at 28.5, 52.5, and 76.5 hours after delivery. No adverse events occurred in either of the 2 groups.Conclusions and relevance: results of this trial showed that acupoint hot compress after vaginal delivery decreased postpartum urinary retention, uterine contraction pain, and depressive symptoms and increased breastfeeding milk volume. Acupoint hot compress may be considered as an adjunctive intervention in postnatal care that meets patient self-care needs.Trial registration: Chinese Clinical Trial Registry Identifier: ChiCTR2000038417</p