Model Tests on Jacked Pile Penetration Characteristics Considering a Static Press-in Piling Machine

This study incorporates a static press-in piling machine into the conventional laboratory model tests for jacked piles. By conducting a comparative analysis between two tests, one involving the static press-in piling machine and the other focusing solely on pile jacking, this study aims to unveil the variations in penetration characteristics with pile sinking depth during the process of pile jacking under the constraint imposed by the static press-in piling machine. When considering the impact of the piling machine, the pile pressing force, pile sinking resistance, pile axial force, and unit side friction resistance of the pile body are higher compared to test results that only focus on pile jacking. There is an acceleration in the total side friction resistance within the depth range of 20 to 30 cm. Additionally, the reduction rate of axial force during the entire pile jacking process is 2% higher, with a general reduction in the “side resistance degradation” phenomenon. The soil pressure around the pile exhibits an initial increase followed by a decrease. The authors believe that the model box test of the jacked pile, considering the pile machine, would be more aligned with engineering practice

Finite Element Analysis of Vacuum Consolidation With Modified Compressibility and Permeability Parameters

Laboratory tests and case history studies indicate that soil subjected to vacuum preloading may not behave the same as ground treated by traditional surcharge preloading. In detail, soil compression under vacuum pressure is smaller than or equal to that induced by positive pressure with the same magnitude; soil rebound after stopping the vacuum is not as high as after removing the surcharge; and the consolidation rate is usually faster under vacuum pressure than with surcharge preloading. Analysis of vacuum consolidation with existing methods cannot gain all these differences. Thus, in this study, three factors for adjusting compressibility and permeability are proposed based on past laboratory and field results which are used in a finite element analysis of soft soil foundation under vacuum-assisted preloading. This proposed method can be incorporated in existing computer programs associated with classical soil models (e.g., the modified Cam-Clay model and the Soft-Soil model); it is then examined via three distinct simulation scenarios including a laboratory model test and two prototype field cases. The improved accuracy in relation to consolidation by the proposed method is demonstrated and practical ranges for the adjustment factors are discussed

One-Dimensional Solar Energy Thermal Consolidation Model Testing and Analytical Calculation for Marine Soft Clays

There are significant energy and financial expenditures associated with the current thermal drainage consolidation approach used to treat the marine soft clay foundation. Especially for some reclaimed lands in remote areas where a large amount of stable electricity is not readily available. In view of the problem, this paper aims to investigate a novel treatment method by using solar energy thermal consolidation. The model testing was conducted to assess the treatment effect of the foundation. Results from two groups of one-dimensional surcharge preloading consolidation model experiments, conducted under conditions of both solar heating and ambient temperature, were presented. The advantage of the solar heating approach was demonstrated by a comparison of the two tests. An analytical calculation method was proposed for predicting the consolidation behavior on the basis of the temperature variation caused by solar energy in the marine soft clays, and good agreement was observed. The outcomes reveal that solar heating can improve the consolidation effect of soil deep in the foundation. The foundation temperature can be raised by 15 °C in winter, and the variation range can exceed 10 °C. The settlement increases by 16% compared with the ambient temperature group

One-Dimensional Solar Energy Thermal Consolidation Model Testing and Analytical Calculation for Marine Soft Clays

There are significant energy and financial expenditures associated with the current thermal drainage consolidation approach used to treat the marine soft clay foundation. Especially for some reclaimed lands in remote areas where a large amount of stable electricity is not readily available. In view of the problem, this paper aims to investigate a novel treatment method by using solar energy thermal consolidation. The model testing was conducted to assess the treatment effect of the foundation. Results from two groups of one-dimensional surcharge preloading consolidation model experiments, conducted under conditions of both solar heating and ambient temperature, were presented. The advantage of the solar heating approach was demonstrated by a comparison of the two tests. An analytical calculation method was proposed for predicting the consolidation behavior on the basis of the temperature variation caused by solar energy in the marine soft clays, and good agreement was observed. The outcomes reveal that solar heating can improve the consolidation effect of soil deep in the foundation. The foundation temperature can be raised by 15 °C in winter, and the variation range can exceed 10 °C. The settlement increases by 16% compared with the ambient temperature group

Finite Element Analysis of Combined Energy Piles with Long and Short Heat Exchanger Tubes

To improve the heat exchange effect of energy piles in coastal areas, a new energy pile with a combination of long and short heat exchanger tubes is proposed. This technology combines the characteristics of implanted pile construction and arranges heat exchanger tubes of different lengths inside and outside the precast pipe pile, which can make full use of the geological conditions in coastal areas. Finite element analysis was applied for a project in a deep, soft soil ground to study the effectiveness of the new combined energy pile technology. The influences of the combined heat exchanger tubes and groundwater seepage conditions on the heat transfer and stress state of the energy pile were analyzed. The results show that the deformation and internal force of the pile body are closely related to temperature change. The temperature change is determined by heat transfer, which is closely related to the arrangement of heat exchanger tubes and underground water flow. With the increase of groundwater seepage velocity, the heat taken away by the heat exchanger tubes gradually increases; thus, the heat exchange between the heat exchanger tubes and the pile body decreases. The inner heat exchanger tube of the pile leads to an increase in heat exchange. However, as the length of the inner heat exchanger tube increases from 40 m to 80 m, the heat exchange decreases. The research results provide technical support for further development of the new energy pile technology

LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing

Abstract Adipose stem cells (ASCs) have attracted considerable attention as potential therapeutic agents due to their ability to promote tissue regeneration. However, their limited tissue repair capability has posed a challenge in achieving optimal therapeutic outcomes. Herein, we conceive a series of lipid nanoparticles to reprogram ASCs with durable protein secretion capacity for enhanced tissue engineering and regeneration. In vitro studies identify that the isomannide-derived lipid nanoparticles (DIM1T LNP) efficiently deliver RNAs to ASCs. Co-delivery of self-amplifying RNA (saRNA) and E3 mRNA complex (the combination of saRNA and E3 mRNA is named SEC) using DIM1T LNP modulates host immune responses against saRNAs and facilitates the durable production of proteins of interest in ASCs. The DIM1T LNP-SEC engineered ASCs (DS-ASCs) prolong expression of hepatocyte growth factor (HGF) and C-X-C motif chemokine ligand 12 (CXCL12), which show superior wound healing efficacy over their wild-type and DIM1T LNP-mRNA counterparts in the diabetic cutaneous wound model. Overall, this work suggests LNPs as an effective platform to engineer ASCs with enhanced protein generation ability, expediting the development of ASCs-based cell therapies

STING Agonist-Derived LNP-mRNA Vaccine Enhances Protective Immunity Against SARS-CoV‑2

Lipid nanoparticle (LNP)-mediated delivery of messenger RNA (mRNA) COVID-19 vaccines has provided large-scale immune protection to the public. To elicit a robust immune response against SARS-CoV-2 infections, antigens produced by mRNAs encoding SARS-CoV-2 Spike glycoprotein need to be efficiently delivered and presented to antigen-presenting cells such as dendritic cells (DCs). As concurrent innate immune stimulation can facilitate the antigen presentation process, a library of non-nucleotide STING agonist-derived amino lipids (SALs) was synthesized and formulated into LNPs for mRNA delivery. SAL12 lipid nanoparticles (SAL12-LNPs) were identified as most potent in delivering mRNAs encoding the Spike glycoprotein (S) of SARS-CoV-2 while activating the STING pathway in DCs. Two doses of SAL12 S-LNPs by intramuscular immunization elicited potent neutralizing antibodies against SARS-CoV-2 in mice