<i>p</i>‑Terphenyl Derivatives from the Endolichenic Fungus <i>Floricola striata</i>

Ten new <i>p</i>-terphenyl derivatives, floricolins A–J (<b>1</b>–<b>10</b>), together with six known compounds (<b>11</b>–<b>16</b>), were isolated from the extract of the endolichenic fungus <i>Floricola striata</i>. Chemical structures of these compounds were elucidated using spectroscopic data (HRESIMS and NMR). Among them, <b>9</b> and <b>10</b> were enantiomeric mixtures, and their configurations were established by single-crystal X-ray diffraction analysis using Cu Kα radiation. Evaluation of the isolated compounds against <i>Candida albicans</i> revealed that the most active compound, <b>3</b> (MIC 8 μg/mL), exerted fungicidal action by destruction of the cell membrane