Exploring the development of localization of county image construction in Anhui Province under the perspective of media fusion

The research is financed by Social Science Project of Anhui Provincial Education Department - Key Project- SK2021A0015. Abstract With the unprecedented attention paid to the construction of county-level integrated media centres, the importance of building and disseminating the image of counties has been overlooked. This paper focuses on the practice of county-level integrated media centres in Anhui Province, and explores the development of localised county image construction in the context of media fusion, so as to help county-level integrated media centres effectively integrate into the ecological cycle of county development and further improve the communication and marketing of county images. Keywords: county image building, county integrated media centre, media image DOI: 10.7176/NMMC/104-09 Publication date: June 30th 2023

Parallelization of dissipative particle dynamics simulation

The dissipative particle dynamics simulation is usually used to study polymer in mesoscopic space. The traditional methods are resource intensive, especially when the scale of research is large. Therefore, improving computing efficiency is a key point in this research area. Two major issues are addressed in this paper. First, the DPD methods are analysed and the most time-consuming parts are identified: conservative force, dissipative force and random force. Second, we describe how to parallelize the existing serial application in the Windows Compute Cluster Server (WCCS) platform. The results show that the parallel algorithm not only effectively shortens the computing time, but also improves the resource utilization rate.<br /

Variance Reduced Random Relaxed Projection Method for Constrained Finite-sum Minimization Problems

For many applications in signal processing and machine learning, we are tasked with minimizing a large sum of convex functions subject to a large number of convex constraints. In this paper, we devise a new random projection method (RPM) to efficiently solve this problem. Compared with existing RPMs, our proposed algorithm features two useful algorithmic ideas. First, at each iteration, instead of projecting onto the subset defined by one of the constraints, our algorithm only requires projecting onto a half-space approximation of the subset, which significantly reduces the computational cost as it admits a closed-form formula. Second, to exploit the structure that the objective is a sum, variance reduction is incorporated into our algorithm to further improve the performance. As theoretical contributions, under an error bound condition and other standard assumptions, we prove that the proposed RPM converges to an optimal solution and that both optimality and feasibility gaps vanish at a sublinear rate. We also provide sufficient conditions for the error bound condition to hold. Experiments on a beamforming problem and a robust classification problem are also presented to demonstrate the superiority of our RPM over existing ones

Comparison of [11C]TZ1964B and [18F]MNI659 for PET imaging brain PDE10A in nonhuman primates

Phosphodiesterase 10A (PDE10A) inhibitors show therapeutic effects for diseases with striatal pathology. PET radiotracers have been developed to quantify in vivo PDE10A levels and target engagement for therapeutic interventions. The aim of this study was to compare two potent and selective PDE10A radiotracers, [(11)C]TZ1964B and [(18)F]MNI659 in the nonhuman primate (NHP) brain. Double scans in the same cynomolgus monkey on the same day were performed after injection of [(11)C]TZ1964B and [(18)F]MNI659. Specific uptake was determined in two ways: nondisplaceable binding potential (BP(ND)) was calculated using cerebellum as the reference region and the PDE‐10A enriched striatum as the target region of interest (ROI); the area under the time–activity curve (AUC) for the striatum to cerebellum ratio was also calculated. High‐performance liquid chromatography (HPLC) analysis of solvent‐extracted NHP plasma identified the percentage of intact tracer versus radiolabeled metabolites samples post injection of each radiotracer. Both radiotracers showed high specific accumulation in NHP striatum. [(11)C]TZ1964B has higher striatal retention and lower specific striatal uptake than [(18)F]MNI659. The BP(ND) estimates of [(11)C]TZ1964B were 3.72 by Logan Reference model (LoganREF) and 4.39 by simplified reference tissue model (SRTM); the BP(ND) estimates for [(18)F]MNI659 were 5.08 (LoganREF) and 5.33 (SRTM). AUC ratios were 5.87 for [(11)C]TZ1964B and 7.60 for [(18)F]MNI659. Based on BP(ND) values in NHP striatum, coefficients of variation were ~10% for [(11)C]TZ1964B and ~30% for [(18)F]MNI659. Moreover, the metabolism study showed the percentage of parent compounds were ~70% for [(11)C]TZ1964B and ~50% for [(18)F]MNI659 60 min post injection. These data indicate that either [(11)C]TZ1964B or [(18)F]MNI659 could serve as suitable PDE10A PET radiotracers with distinguishing features for particular clinical application