A Three-Flavor AdS/QCD Model with a Back-Reacted Geometry

A fully back-reaction geometry model of AdS/QCD including the strange quark is described. We find that with the inclusion of the strange quark the impact on the metric is very small and the final predictions are changed only negligibly.Comment: 10 pages, 2 figures; references revised, minor change for caption of fig

AdS/QCD Phenomenological Models from a Back-Reacted Geometry

We construct a fully back-reacted holographic dual of a four-dimensional field theory which exhibits chiral symmetry breaking. Two possible models are considered by studying the effects of a five-dimensional field, dual to the $q\bar{q}$ operator. One model has smooth geometry at all radii and the other dynamically generates a cutoff at finite radius. Both of these models satisfy Einstein's field equations. The second model has only three free parameters, as in QCD, and we show that this gives phenomenologically consistent results. We also discuss the possibility that in order to obtain linear confinement from a back-reacted model it may be necessary to consider the condensate of a dimension two operator.Comment: 13 pages, 4 figures, Replaced with minor correction

Low-temperature nonequilibrium transport in a Luttinger liquid

The temperature-dependent nonlinear conductance for transport of a Luttinger liquid through a barrier is calculated in the nonperturbative regime for $g=1/2-\epsilon$, where $g$ is the dimensionless interaction constant. To describe the low-energy behavior, we perform a leading-log summation of all diagrams contributing to the conductance which is valid for $|\epsilon| << 1$. With increasing external voltage, the asymptotic low-temperature behavior displays a turnover from the $T^{2/g-2}$ to a universal $T^2$ law.Comment: 13 pages RevTeX 3.0, accepted by Physical Review

Comparative analysis of the testis and ovary transcriptomes in Zebrafish by combining experimental and computational tools

Studies on the zebrafish model have contributed to our understanding of several important developmental processes, especially those that can be easily studied in the embryo. However, our knowledge on late events such as gonad differentiation in the zebrafish is still limited. Here we provide an analysis on the gene sets expressed in the adult zebrafish testis and ovary in an attempt to identify genes with potential role in (zebra)fish gonad development and function. We produced 10,533 expressed sequence tags (ESTs) from zebrafish testis or ovary and downloaded an additional 23,642 gonad-derived sequences from the zebrafish EST database. We clustered these sequences together with over 13,000 kidney-derived zebrafish ESTs to study partial transcriptomes for these three organs. We searched for genes with gonad-specific expression by screening macroarrays containing at least 2600 unique cDNA inserts with testis-, ovary- and kidney-derived cDNA probes. Clones hybridizing to only one of the two gonad probes were selected, and subsequently screened with computational tools to identify 72 genes with potentially testis-specific and 97 genes with potentially ovary-specific expression, respectively. PCR-amplification confirmed gonad-specificity for 21 of the 45 clones tested (all without known function). Our study, which involves over 47,000 EST sequences and specialized cDNA arrays, is the first analysis of adult organ transcriptomes of zebrafish at such a scale. The study of genes expressed in adult zebrafish testis and ovary will provide useful information on regulation of gene expression in teleost gonads and might also contribute to our understanding of the development and differentiation of reproductive organs in vertebrates

Gravitational Contributions to the Running of Gauge Couplings

Gravitational contributions to the running of gauge couplings are calculated by using different regularization schemes. As the $\beta$ function concerns counter-terms of dimension four, only quadratic divergences from the gravitational contributions need to be investigated. A consistent result is obtained by using a symmetry-preserving loop regularization with string-mode regulators which can appropriately treat the quadratic divergences and preserve non-abelian gauge symmetry. The harmonic gauge condition for gravity is used in both diagrammatical and background field calculations, the resulting gravitational corrections to the $\beta$ function are found to be nonzero, which is different from previous results presented in the existing literatures.Comment: 5 pages, 2 figures, published versio

Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal

SummaryLow energy states delay aging in multiple species, yet mechanisms coordinating energetics and longevity across tissues remain poorly defined. The conserved energy sensor AMP-activated protein kinase (AMPK) and its corresponding phosphatase calcineurin modulate longevity via the CREB regulated transcriptional coactivator (CRTC)-1 in C. elegans. We show that CRTC-1 specifically uncouples AMPK/calcineurin-mediated effects on lifespan from pleiotropic side effects by reprogramming mitochondrial and metabolic function. This pro-longevity metabolic state is regulated cell nonautonomously by CRTC-1 in the nervous system. Neuronal CRTC-1/CREB regulates peripheral metabolism antagonistically with the functional PPARα ortholog, NHR-49, drives mitochondrial fragmentation in distal tissues, and suppresses the effects of AMPK on systemic mitochondrial metabolism and longevity via a cell-nonautonomous catecholamine signal. These results demonstrate that while both local and distal mechanisms combine to modulate aging, distal regulation overrides local contribution. Targeting central perception of energetic state is therefore a potential strategy to promote healthy aging

Spin- and charge-density oscillations in spin chains and quantum wires

We analyze the spin- and charge-density oscillations near impurities in spin chains and quantum wires. These so-called Friedel oscillations give detailed information about the impurity and also about the interactions in the system. The temperature dependence of these oscillations explicitly shows the renormalization of backscattering and conductivity, which we analyze for a number of different impurity models. We are also able to analyze screening effects in one dimension. The relation to the Kondo effect and experimental consequences are discussed.Comment: Final published version. 15 pages in revtex format including 22 epsf-embedded figures. The latest version in PDF format is available from http://fy.chalmers.se/~eggert/papers/density-osc.pd

Integrable twists in AdS/CFT

A class of marginal deformations of four-dimensional N=4 super Yang-Mills theory has been found to correspond to a set of smooth, multiparameter deformations of the S^5 target subspace in the holographic dual on AdS_5 x S^5. We present here an analogous set of deformations that act on global toroidal isometries in the AdS_5 subspace. Remarkably, certain sectors of the string theory remain classically integrable in this larger class of so-called gamma-deformed AdS_5 x S^5 backgrounds. Relying on studies of deformed su(2)_gamma models, we formulate a local sl(2)_gamma Lax representation that admits a classical, thermodynamic Bethe equation (based on the Riemann-Hilbert interpretation of Bethe's ansatz) encoding the spectrum in the deformed AdS_5 geometry. This result is extended to a set of discretized, asymptotic Bethe equations for the twisted string theory. Near-pp-wave energy spectra within sl(2)_gamma and su(2)_gamma sectors provide a useful and stringent test of such equations, demonstrating the reliability of this technology in a wider class of string backgrounds. In addition, we study a twisted Hubbard model that yields certain predictions of the dual beta-deformed gauge theory.Comment: v2: references and clarifications added, 46 page

Chromomagnetic Dipole Moment of the Top Quark Revisited

We study the complete one-loop contributions to the chromagnetic dipole moment $\Delta\kappa$ of the top quark in the Standard Model, two Higgs doublet models, topcolor assited technicolor models (TC2), 331 models and extended models with a single extra dimension. We find that the SM predicts $\Delta\kappa = - 0.056$ and that the predictions of the other models are also consitent with the constraints imposed on $\Delta\kappa$ by low-energy precision measurements.Comment: 20 pages, 5 figures, Updat

Au-siRNA@ aptamer nanocages as a high-efficiency drug and gene delivery system for targeted lung cancer therapy

Background: Gene and chemical therapy has become one of the rising stars in the field of molecular medicine during the last two decades. However, there are still numerous challenges in the development of efficient, targeted, and safe delivery systems that can avoid siRNA degradation and reduce the toxicity and adverse effects of chemotherapy medicine. Results: In this paper, a highly efficient AS1411 aptamer modified, dsDNA and MMP-2 cleavable peptide-fabricated gold nanocage vehicle, which could load doxorubicin hydrochloride (DOX) and siRNAs to achieve a combination of tumor responsive genetic therapy, chemotherapy, and photothermal treatment is presented. Our results show that this combined treatment achieved targeted gene silencing and tumor inhibition. After nearly one month of treatment with DOX-loaded Au-siRNA-PAA-AS1411 nanoparticles with one dose every three days in mice, a synergistic effect promoting the eradication of long-lived tumors was observed along with an increased survival rate of mice. The combined genetic, chemotherapeutic, and photothermal treatment group exhibited more than 90% tumor inhibition ratio (tumor signal) and a ~ 67% survival rate compared with a 30% tumor inhibition ratio and a 0% survival rate in the passive genetic treatment group. Conclusions: The development of nanocarriers with double-stranded DNA and MMP-2 cleavable peptides provides a new strategy for the combined delivery of gene and chemotherapy medicine. Au-siRNA-PAA-AS1411 exerts high anticancer activities on lung cancer, indicating immense potentials for clinical application.[Figure not available: see fulltext.