1 research outputs found
Biotemplated Syntheses of Macroporous Materials for Bone Tissue Engineering Scaffolds and Experiments in Vitro and Vivo
The
macroporous materials were prepared from the transformation of cuttlebone
as biotemplates under hydrothermal reactions and characterized by
Fourier transform infrared spectroscopy (FTIR), X-ray diffraction
(XRD), thermogravimetric/differential thermal analyses (TG-DTA), and
scanning electron microscopy (SEM). Cell experimental results showed
that the prepared materials as bone tissue engineering scaffolds or
fillers had fine biocompatibility suitable for adhesion and proliferation
of the hMSCs (human marrow mesenchymal stem cells). Histological analyses
were carried out by implanting the scaffolds into a rabbit femur,
where the bioresorption, degradation, and biological activity of the
scaffolds were observed in the animal body. The prepared scaffolds
kept the original three-dimensional frameworks with the ordered porous
structures, which made for blood circulation, nutrition supply, and
the cells implantation. The biotemplated syntheses could provide a
new effective approach to prepare the bone tissue engineering scaffold
materials