2 research outputs found
Hierarchical Structure Formation and Effect Mechanism of Ni/Mn Layered Double Hydroxides Microspheres with Large-Scale Production for Flexible Asymmetric Supercapacitors
In
this study, Ni/Mn layered double hydroxides (LDHs) microspheres with
three-dimensional flower-like hierarchical structure are fabricated
by a large-scale and self-assembled chemical coprecipitation strategy
(at 55 °C under normal pressure). In each integrated microsphere,
the petals consist of ultrathin two-dimensional nanosheets. The self-assembly
formation mechanism of this flower-like construction is systematically
investigated according to the analysis results from the regulation
of various reaction factors. The Ni/Mn LDHs microspheres show an optimal
capacitance value as high as 1379 F·g<sup>–1</sup> at
1 A·g<sup>–1</sup>. Sum frequency generation spectroscopy
and charge storage behavior mechanism analysis further demonstrate
that a favorable capacitive constitution is indeed dependent on the
synergistic effect of active sites (different feed ratios) and surface
area (different architectural features). Moreover, a novel flexible
all-solid-state asymmetric supercapacitor is assembled by exploiting
these microspheres and active carbon as positive and negative electrode
materials respectively, which exhibits a superior capacitance value
of 393 F·g<sup>–1</sup> (1 A·g<sup>–1</sup>) and energy and power density of 131.17 Wh·kg<sup>–1</sup> and 1.45 KW·kg<sup>–1</sup> with favorable cyclic life
(remains over 75.1% after 5000 cycles under 50 mV·s<sup>–1</sup>), respectively. Overall, this work provides a significant prospect
and deep understanding for the development of the next generation
of flexible energy devices
Table_2_Classification related to immunogenic cell death predicts prognosis, immune microenvironment characteristics, and response to immunotherapy in lower-grade gliomas.xlsx
BackgroundImmunogenic cell death (ICD) is a form of cell death that elicits immune responses against the antigens found in dead or dying tumor cells. Growing evidence implies that ICD plays a significant role in triggering antitumor immunity. The prognosis for glioma remains poor despite many biomarkers being reported, and identifying ICD-related biomarkers is imminent for better-personalized management in patients with lower-grade glioma (LGG).Materials and methodsWe identified ICD-related differentially expressed genes (DEGs) by comparing gene expression profiles obtained across Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) cohorts. On the foundation of ICD-related DEGs, two ICD-related clusters were identified through consensus clustering. Then, survival analysis, functional enrichment analysis, somatic mutation analysis, and immune characteristics analysis were performed in the two ICD-related subtypes. Additionally, we developed and validated a risk assessment signature for LGG patients. Finally, we selected one gene (EIF2AK3) from the above risk model for experimental validation.Results32 ICD-related DEGs were screened, dividing the LGG samples from the TCGA database into two distinct subtypes. The ICD-high subgroup showed worse overall survival (OS), greater immune infiltration, more active immune response process, and higher expression levels of HLA genes than the ICD-low subgroup. Additionally, nine ICD-related DEGs were identified to build the prognostic signature, which was highly correlated with the tumor-immune microenvironment and could unambiguously be taken as an independent prognostic factor and further verified in an external dataset. The experimental results indicated that EIF2AK3 expression was higher in tumors than paracancerous tissues, and high-expression EIF2AK3 was enriched in WHO III and IV gliomas by qPCR and IHC, and Knockdown of EIF2AK3 suppressed cell viability and mobility in glioma cells.ConclusionWe established novel ICD-related subtypes and risk signature for LGG, which may be beneficial to improving clinical outcome prediction and guiding individualized immunotherapy.</p