1 research outputs found
Neochlorogenic Acid Combined with Bone Marrow Mesenchymal Stem Cells Encapsulated into GelMA Hydrogel for Transplantation to Repair Intervertebral Disk Degeneration
Intervertebral disk
degeneration is a common disease with an unknown
etiology. Currently, tissue engineering is considered to be an important
method for intervertebral disk repair. Although transplanted stem
cells may disrupt the repair process because of apoptosis caused by
the oxidative microenvironment. Herein, bone marrow mesenchymal stem
cell (BMSC) and Neochlorogenic acid (Ncg) were encapsulated into a
GelMA hydrogel as a carrier to protect transplanted stem cells. Ncg
effectively inhibited the oxidative stress process and reduced the
apoptosis rate. A 5% GelMA hydrogel had a large pore size and porosity
that provided an enhanced survival space for cells. An in vivo assessment
showed that treatment with GelMA + BMSC + Ncg produced greater repair
of degenerated intervertebral disks than that found in other model
groups. Thus, this study may help contribute to improving stem cell
transplantation for treating intervertebral disk degeneration