Analysis of Standing Seam Metal Roofs Subjected to Extreme Wind Loads

Standing seam metal roof (SSMR) systems are widely used in low-rise buildings. This study aims to understand the behavior of SSMR systems, especially the failure mechanisms, under severe wind loads. Full-scale experiments conducted at Insurance Research Lab for Better Homes make it possible to examine the performance of SSMR systems with realistic dimensions and boundary conditions. The induced loads on the clips could be measured directly. The results show that there is a linear relationship between the wind pressure and clip reaction under low wind pressure (less than 500 Pa). It is found that load sharing among clips changes at higher pressures due to the large deformation of the roof panel. As a result, more loads transfer to the clips and fasteners at the roof edges. Finite element method considers all nonlinearities (e.g., geometric, contact, and material nonlinearities) in the wind-induced response of SSMR systems, which reveal the whole process of failure. The initial location of global buckling, the disengagement failure between panel and clip at seam were simulated, which is consistent with the observation from the experiment. Both the finite element method and experiment show that the roof panel undergoes overall buckling before the roof system reach the ultimate bearing capacity and the initial position of overall buckling is in the middle of the two clips near the seam. Moreover, the results show the boundary conditions have notable effects on load distribution while these were usually ignored by the current standards. An updated analytical model was proposed using the influence function concept. The performance of the standing seam can be considered as a continuous beam with modeling clips and fasteners as vertical springs. Using the Database-assisted design (DAD) method, the clip reactions under spatio-temporal varying pressure were studied, which is also compared with the results from standards. It is found that the estimated clip reactions using GB 50009 (2012) are much smaller than the peaks using the DAD method, which makes the clips more vulnerable under severe wind suction. In contrast, ASCE 7-16 gives a conservative estimation of clip reaction

Steady periodic irrotational blood flow with time-dependent body force

In this paper, we study steady 2D periodic blood flow propagating along blood vessels with free boundary conditions. In particular, we focus on the dynamic behavior of irrotational flows with time dependent body force. An equivalent formulation with fix boundary is developed by utilizing flow force functions. The local bifurcation result is obtained by Crandall-Rabinowitz theorem. The existence of a local $C^1$-curve of small-amplitude solution is strictly proved

Decoding Taste Information in Human Brain: A Temporal and Spatial Reconstruction Data Augmentation Method Coupled with Taste EEG

For humans, taste is essential for perceiving food's nutrient content or harmful components. The current sensory evaluation of taste mainly relies on artificial sensory evaluation and electronic tongue, but the former has strong subjectivity and poor repeatability, and the latter is not flexible enough. This work proposed a strategy for acquiring and recognizing taste electroencephalogram (EEG), aiming to decode people's objective perception of taste through taste EEG. Firstly, according to the proposed experimental paradigm, the taste EEG of subjects under different taste stimulation was collected. Secondly, to avoid insufficient training of the model due to the small number of taste EEG samples, a Temporal and Spatial Reconstruction Data Augmentation (TSRDA) method was proposed, which effectively augmented the taste EEG by reconstructing the taste EEG's important features in temporal and spatial dimensions. Thirdly, a multi-view channel attention module was introduced into a designed convolutional neural network to extract the important features of the augmented taste EEG. The proposed method has accuracy of 99.56%, F1-score of 99.48%, and kappa of 99.38%, proving the method's ability to distinguish the taste EEG evoked by different taste stimuli successfully. In summary, combining TSRDA with taste EEG technology provides an objective and effective method for sensory evaluation of food taste.Comment: 10 pages, 11 figures, 30 references, article is being submitte

Copy number analysis of whole-genome data using BIC-seq2 and its application to detection of cancer susceptibility variants

Whole-genome sequencing data allow detection of copy number variation (CNV) at high resolution. However, estimation based on read coverage along the genome suffers from bias due to GC content and other factors. Here, we develop an algorithm called BIC-seq2 that combines normalization of the data at the nucleotide level and Bayesian information criterion-based segmentation to detect both somatic and germline CNVs accurately. Analysis of simulation data showed that this method outperforms existing methods. We apply this algorithm to low coverage whole-genome sequencing data from peripheral blood of nearly a thousand patients across eleven cancer types in The Cancer Genome Atlas (TCGA) to identify cancer-predisposing CNV regions. We confirm known regions and discover new ones including those covering KMT2C, GOLPH3, ERBB2 and PLAG1. Analysis of colorectal cancer genomes in particular reveals novel recurrent CNVs including deletions at two chromatin-remodeling genes RERE and NPM2. This method will be useful to many researchers interested in profiling CNVs from whole-genome sequencing data

Trimester-and Assay-Specific Thyroid Reference Intervals for Pregnant Women in China

Objective. The guidelines of the American Thyroid Association (ATA) recommend an upper limit reference interval (RI) of thyroid stimulating hormone (TSH) of 2.5 mIU/L in the first trimester of pregnancy and 3.0 mIU/L in subsequent trimesters, but some reported ranges in China are significantly higher. Our study aimed to establish trimester-and assay-specific RIs for thyroid hormones in normal pregnant Chinese women. Methods. In this cross-sectional study, 2540 women with normal pregnancies (first trimester, = 398; second trimester, = 797; third trimester, = 1345) and 237 healthy nonpregnant control subjects were recruited. Serum TSH, free thyroxin (FT4), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) levels were determined by automated chemiluminescence with an Immulite 2000 system (Siemens, Erlangen, Germany). After outliers were excluded, the 2.5-97.5th percentiles were used to define the RIs. Results. The RIs of thyroid function in the first, second, and third trimesters of pregnancy and in nonpregnant controls were 0. .61 pmol/L for FT4, respectively. Conclusion. The trimester-and assay-specific RIs of thyroid function during pregnancy differed between trimesters, which suggests that it is advisable to detect and avoid misclassification of thyroid dysfunction during pregnancy for women in Henan, China

Trimester- and Assay-Specific Thyroid Reference Intervals for Pregnant Women in China

Objective. The guidelines of the American Thyroid Association (ATA) recommend an upper limit reference interval (RI) of thyroid stimulating hormone (TSH) of 2.5 mIU/L in the first trimester of pregnancy and 3.0 mIU/L in subsequent trimesters, but some reported ranges in China are significantly higher. Our study aimed to establish trimester- and assay-specific RIs for thyroid hormones in normal pregnant Chinese women. Methods. In this cross-sectional study, 2540 women with normal pregnancies (first trimester, n=398; second trimester, n=797; third trimester, n=1345) and 237 healthy nonpregnant control subjects were recruited. Serum TSH, free thyroxin (FT4), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) levels were determined by automated chemiluminescence with an Immulite 2000 system (Siemens, Erlangen, Germany). After outliers were excluded, the 2.5–97.5th percentiles were used to define the RIs. Results. The RIs of thyroid function in the first, second, and third trimesters of pregnancy and in nonpregnant controls were 0.07–3.96, 0.27–4.53, 0.48–5.40, and 0.69–5.78 mIU/L for TSH and 9.16–18.12, 8.67–16.21, 7.80–13.90, and 8.24–16.61 pmol/L for FT4, respectively. Conclusion. The trimester- and assay-specific RIs of thyroid function during pregnancy differed between trimesters, which suggests that it is advisable to detect and avoid misclassification of thyroid dysfunction during pregnancy for women in Henan, China

Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations

Approximately half of the world's 500,000 new oesophageal squamous-cell carcinoma (ESCC) cases each year occur in China. Here, we show whole-genome sequencing of DNA and RNA in 94 Chinese individuals with ESCC. We identify six mutational signatures (E1–E6), and Signature E4 is unique in ESCC linked to alcohol intake and genetic variants in alcohol-metabolizing enzymes. We discover significantly recurrent mutations in 20 protein-coding genes, 4 long non-coding RNAs and 10 untranslational regions. Functional analyses show six genes that have recurrent copy-number variants in three squamous-cell carcinomas (oesophageal, head and neck and lung) significantly promote cancer cell proliferation, migration and invasion. The most frequently affected genes by structural variation are LRP1B and TTC28. The aberrant cell cycle and PI3K-AKT pathways seem critical in ESCC. These results establish a comprehensive genomic landscape of ESCC and provide potential targets for precision treatment and prevention of the cancer

The eigenvector-eigenvalue identity for the quaternion matrix with its algorithm and computer program

Peter Denton, Stephen Parke, Terence Tao and Xining Zhang [arxiv 2019] presented a basic and important identity in linear commutative algebra, so-called {\bf the eigenvector-eigenvalue identity} (formally named in [BAMS, 2021]), which is a convenient and powerful tool to succinctly determine eigenvectors from eigenvalues. The identity relates the eigenvector component to the eigenvalues of $A$ and the minor $M_j$, which is formulated in an elegant form as $$\lvert v_{i,j} \rvert^2\prod_{k=1;k\ne i}^{n-1}({\lambda_i}(A)-{\lambda_k}(A))=\prod_{k=1}^{n-1}({\lambda_i}(A)-{\lambda_k}(M_j)). \,\,\,$$ In fact, it has been widely applied in various fields such as numerical linear algebra, random matrix theory, inverse eigenvalue problem, graph theory, neutrino physics and so on. In this paper, we extend the eigenvector-eigenvalue identity to the quaternion division ring, which is non-commutative. A version of eigenvector-eigenvalue identity for the quaternion matrix is established. Furthermore, we give a new method and algorithm to compute the eigenvectors from the right eigenvalues for the quaternion Hermitian matrix. A program is designed to realize the algorithm to compute the eigenvectors. An open problem ends the paper. Some examples show a good performance of the algorithm and the program

Investigation on Mechanical Properties of a Carbon Paper Gas Diffusion Layer through a 3-D Nonlinear and Orthotropic Constitutive Model

The mechanical loads that gas diffusion layers (GDLs) withstand in polymer electrolyte membrane fuel cell (PEMFC) stacks are sensitive to the assembly and working conditions. The mechanical properties of GDLs mostly depend on their composition materials, microstructural characteristics, operation conditions, etc. An accurate and comprehensive understanding of the mechanical performance of GDLs is significant for predicting the stress distribution and improving the assembly technology of PEMFC stacks. This study presented a novel 3-D nonlinear and orthotropic constitutive model of a carbon paper GDL to represent the material stiffness matrix with its compressive, tensile, and shear properties. Numerical simulations were performed based on the 3-D constitutive model, and the proposed 3-D model was validated against the experimental data reported previously. It is found that the simulation results of the 3-D constitutive model show a good agreement with the experimental results. Besides, the novel 3-D nonlinear and orthotropic model was applied in the overall stress simulation of a simplified PEMFC unit cell, compared to a conventional 3-D linear and isotropic model, and the simulation results of the two models show a significant difference