Association between Polymorphism of Interleukin-1beta and Interleukin-1 Receptor Antagonist Gene and Asthma Risk: A Meta-Analysis

Background. Asthma is a complex polygenic disease in which gene-environment interactions are important. A number of studies have investigated the polymorphism of IL-1β -511C/T and IL-1RA genes in relation to asthma susceptibility in different populations. However, the results of individual studies have been inconsistent. Accordingly, we conducted a comprehensive meta-analysis to investigate the association between the IL-1β -511C/T and IL-1RA polymorphism and asthma risk. Methods. Data were collected from the following electronic databases: Pub Med, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), ISI Web of Knowledge, and Google Scholar Search databases with the last report up to July 2013. Finally, 15 studies were included in our meta-analysis. We summarized the data on the association between IL-1β -511C/T and IL-1RA polymorphism and risk of asthma in the overall population and performed subgroup analyses by ethnicity, mean of age, and source of controls. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the associations between IL-1β -511C/T and IL-1RA polymorphism and asthma risk. Statistical analysis was performed with Review Manager 5.1. Results. A total of 15 case-control studies were included in the meta-analysis of IL-1β -511C/T (1,385 cases and 1,964 controls) and IL-1RA (2,800 cases and 6,359 controls) genotypes. No association was found between IL-1β -511C/T polymorphism and asthma risk (dominant model: OR=1.11, 95% CI: 0.99–1.25, P=0.07, PHeterogeneity=0.06; recessive model: OR=1.04, 95% CI: 0.91–1.20, P=0.55, PHeterogeneity=0.11). Subgroup analysis based on ethnicity (Asian and Caucasian), source of controls (population-based controls and hospital-based controls), and mean of age (adulthood and childhood) did not present any significant association. The overall results showed that the IL-1RA polymorphism was related to an increased risk of asthma (homozygote model: OR=1.32, 95% CI: 1.12–1.56, P=0.0009, PHeterogeneity=0.87; recessive model: OR=1.39, 95% CI: 1.18–1.63, P=0.0001, PHeterogeneity=0.82). Similar results were found in the subgroup analyses by ethnicity, mean of age, and source of controls. Sensitivity analysis did not perturb the results. Conclusions. This meta-analysis provided strong evidence that the IL-1RA polymorphism was a risk factor of asthma, especially in Caucasian populations. However, no association was found for IL-1β -511C/T genotype carriers. Larger scale studies are needed for confirmation

The sugar and energy in non-carbonated sugar-sweetened beverages: a cross-sectional study.

BACKGROUND: The consumption of non-carbonated sugar-sweetened beverages (NCSSBs) has many adverse health effects. However, the sugar and energy content in NCSSBs sold in China remain unknown. We aimed to investigate the sugar and energy content of NCSSBs in China and how these contents were labelled. METHODS: A cross-sectional survey was conducted in 15 supermarkets in Haidian District, Beijing from July to October 2017. The product packaging and nutrient information panels of NCSSBs were recorded to obtain type of products (local/imported), serving size, nutrient contents of carbohydrate, sugar and energy. For those NCSSBs without sugar content information, we used carbohydrate content as a replacement. RESULTS: A total of 463 NCSSBs met the inclusion criteria and were included in our analysis. The median of sugar content and energy content was 9.6 [interquartile range (IQR): 7.1-11.3] g/100 ml and 176 (IQR: 121-201) kJ/100 ml. The median of sugar contents in juice drinks, tea-based beverages, sports drinks and energy drinks were 10.4, 8.5, 5.0 and 7.4 g/100 ml. Imported products had higher sugar and energy content than local products. There were 95.2% products of NCSSBs receiving a 'red'(high) label for sugars per portion according to the UK criteria, and 81.6% products exceeding the daily free sugar intake recommendation from the World Health Organization (25 g). There were 82 (17.7%) products with sugar content on the nutrition labels and 60.2% of them were imported products. CONCLUSIONS: NCSSBs had high sugar and energy content, and few of them provided sugar content information on their nutrition labels especially in local products. Measures including developing better regulation of labelling, reducing sugar content and restricting the serving size are needed for reducing sugar intakes in China

Recognition and Depth Estimation of Ships Based on Binocular Stereo Vision

To improve the navigation safety of inland river ships and enrich the methods of environmental perception, this paper studies the recognition and depth estimation of inland river ships based on binocular stereo vision (BSV). In the stage of ship recognition, considering the computational pressure brought by the huge network parameters of the classic YOLOv4 model, the MobileNetV1 network was proposed as the feature extraction module of the YOLOv4 model. The results indicate that the mAP value of the MobileNetV1-YOLOv4 model reaches 89.25%, the weight size of the backbone network was only 47.6 M, which greatly reduced the amount of computation while ensuring the recognition accuracy. In the stage of depth estimation, this paper proposes a feature point detection and matching algorithm based on the ORB algorithm at sub-pixel level, that is, firstly, the FSRCNN algorithm was used to perform super-resolution reconstruction of the original image, to further increase the density of image feature points and detection accuracy, which was more conducive to the calculation of the image parallax value. The ships’ depth estimation results indicate that when the distance to the target is about 300 m, the depth estimation error is less than 3%, which meets the depth estimation needs of inland ships. The ship target recognition and depth estimation technology based on BSV proposed in this paper makes up for the shortcomings of the existing environmental perception methods, improves the navigation safety of ships to a certain extent, and greatly promotes the development of intelligent ships in the future

Recognition and Depth Estimation of Ships Based on Binocular Stereo Vision

To improve the navigation safety of inland river ships and enrich the methods of environmental perception, this paper studies the recognition and depth estimation of inland river ships based on binocular stereo vision (BSV). In the stage of ship recognition, considering the computational pressure brought by the huge network parameters of the classic YOLOv4 model, the MobileNetV1 network was proposed as the feature extraction module of the YOLOv4 model. The results indicate that the mAP value of the MobileNetV1-YOLOv4 model reaches 89.25%, the weight size of the backbone network was only 47.6 M, which greatly reduced the amount of computation while ensuring the recognition accuracy. In the stage of depth estimation, this paper proposes a feature point detection and matching algorithm based on the ORB algorithm at sub-pixel level, that is, firstly, the FSRCNN algorithm was used to perform super-resolution reconstruction of the original image, to further increase the density of image feature points and detection accuracy, which was more conducive to the calculation of the image parallax value. The ships’ depth estimation results indicate that when the distance to the target is about 300 m, the depth estimation error is less than 3%, which meets the depth estimation needs of inland ships. The ship target recognition and depth estimation technology based on BSV proposed in this paper makes up for the shortcomings of the existing environmental perception methods, improves the navigation safety of ships to a certain extent, and greatly promotes the development of intelligent ships in the future

Small seawater desalination system based on loop heat pipe principle

The small seawater desalination system based on loop heat pipe principle by using plate capillary pump technology, a new type of radiator spoiler evaporator and soaking plate finned condenser to realize desktop-class solar seawater desalination system. The Venturi tube principle is used to reduce the internal pressure and energy consumption, and solar photoelectric board with electric heating board function is used to solve problems for areas where there is a shortage of electricity and fresh water resources. Full automatic control system is used to realize the full automatic operation of the equipment.Desktop-class light and small seawater desalination equipment enjoys a broad market prospect. It can not only be used in islands, fishing boats, offshore operating platforms and other complex working scenarios, but also can be used as a large ship freshwater resources emergency equipment

Prediction of Adverse Outcomes in De Novo Hypertensive Disorders of Pregnancy: Development and Validation of Maternal and Neonatal Prognostic Models

Effectively identifying high-risk patients with de novo hypertensive disorder of pregnancy (HDP) is required to enable timely intervention and to reduce adverse maternal and perinatal outcomes. Electronic medical record of pregnant women with de novo HDP were extracted from a birth cohort in Beijing, China. The adverse outcomes included maternal and fetal morbidities, mortality, or any other adverse complications. A multitude of machine learning statistical methods were employed to develop two prediction models, one for maternal complications and the other for perinatal deteriorations. The maternal model using the random forest algorithm produced an AUC of 0.984 (95% CI (0.978, 0.991)). The strongest predictors variables selected by the model were platelet count, fetal head/abdominal circumference ratio, and gestational age at the diagnosis of de novo HDP; The perinatal model using the boosted tree algorithm yielded an AUC of 0.925 (95% CI (0.907, 0.945]). The strongest predictor variables chosen were gestational age at the diagnosis of de novo HDP, fetal femur length, and fetal head/abdominal circumference ratio. These prediction models can help identify de novo HDP patients at increased risk of complications who might need intense maternal or perinatal care

Risk of De Novo Hypertensive Disorders of Pregnancy After Exposure to PM1 and PM2.5 During the Period From Preconception to Delivery: Birth Cohort Study

BackgroundParticulate matter (PM) is detrimental to the respiratory and circulatory systems. However, no study has evaluated the lag effects of weekly exposure to fine PM during the period from preconception to delivery on the risk of hypertensive disorders of pregnancy (HDPs). ObjectiveWe set out to investigate the lag effect windows of PM on the risk of HDPs on a weekly scale. MethodsData from women with de novo HDPs and normotensive pregnant women who were part of the Peking University Retrospective Birth Cohort, based on the hospital information system of Tongzhou district, were obtained for this study. Meteorological data and data on exposure to fine PM were predicted by satellite remote sensing data based on maternal residential address. The de novo HDP group consisted of pregnant women who were diagnosed with gestational hypertension or preeclampsia. Fine PM was defined as PM2.5 and PM1. The gestational stage of participants was from preconception (starting 12 weeks before gestation) to delivery (before the 42nd gestational week). A distributed-lag nonlinear model (DLNM) was nested in a Cox regression model to evaluate the lag effects of weekly PM exposure on de novo HDP hazard by controlling the nonlinear relationship of exposure–reaction. Stratified analyses by employment status (employed or unemployed), education level (higher or lower), and parity (primiparity or multiparity) were performed. ResultsA total of 22,570 pregnant women (mean age 29.1 years) for whom data were available between 2013 and 2017 were included in this study. The prevalence of de novo HDPs was 6.7% (1520/22,570). Our findings showed that PM1 and PM2.5 were significantly associated with an elevated hazard of HDPs. Exposure to PM1 during the 5th week before gestation to the 6th gestational week increased the hazard of HDPs. A significant lag effect of PM2.5 was observed from the 1st week before gestation to the 6th gestational week. The strongest lag effects of PM1 and PM2.5 on de novo HDPs were observed at week 2 and week 6 (hazard ratio [HR] 1.024, 95% CI 1.007-1.042; HR 1.007, 95% CI 1.000-1.015, respectively, per 10 μg/m3 increase). The stratified analyses indicated that pregnant women who were employed, had low education, and were primiparous were more vulnerable to PM exposure for de novo HDPs. ConclusionsExposure to PM1 and PM2.5 was associated with the risk of de novo HDPs. There were significant lag windows between the preconception period and the first trimester. Women who were employed, had low education, and were primiparous were more vulnerable to the effects of PM exposure; more attention should be paid to these groups for early prevention of de novo HDPs