Copper-Catalyzed Cyclization for Access to 6<i>H</i>‑Chromeno[4,3‑<i>b</i>]quinolin-6-ones Employing DMF as the Carbon Source

The first example of the copper-catalyzed cyclization of 4-(phenylamino)-2<i>H</i>-chromen-2-ones employing the <i>N</i>-methyl moiety of DMF as the source of the methine (CH) group has been developed, providing an efficient synthetic pathway to access novel functionalized 6<i>H</i>-chromeno­[4,3-<i>b</i>]­quinolin-6-ones in moderate to good yields

A Multilayered Silicon-Reduced Graphene Oxide Electrode for High Performance Lithium-Ion Batteries

A multilayered structural silicon-reduced graphene oxide electrode with superior electrochemical performance was synthesized from bulk Si particles through inexpensive electroless etching and graphene self-encapsulating approach. The prepared composite electrode presents a stable charge–discharge performance with high rate, showing a reversible capacity of 2787 mAh g^–1 at a charging rate of 100 mA g^–1, and a stable capacity over 1000 mAh g^–1 was retained at 1 A g^–1 after 50 cycles with a high columbic efficiency of 99% during the whole cycling process. This superior performance can be attributed to its novel multilayered structure with porous Si particles encapsulated, which can effectively accommodate the large volume change during the lithiation process and provide increased electrical conductivity. This facile low-cost approach offers a promising route to develop an optimized carbon encapsulated Si electrode for future industrial applications

Data_Sheet_1_Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma.CSV

Recent studies have found that the protein encoded by the FDX1 gene is involved in mediating Cuproptosis as a regulator of protein lipoylation and related to immune response process of tumors. However, the specific biological function of FDX1 in glioma is currently unclear. To explore the potential function of FDX1, this study explored the correlation between the expression of FDX1 in cancers and survival prognosis by analyzing the public databases of GEPIA and Cbioportal. Immune infiltration was analyzed by the TIMER2.0 database in tumors. The possible biological processes and functions of FDX1-related in glioma were annotated through gene enrichment. Relationship between Cuproptosis and autophagy was explored through gene co-expression studies. Summary and conclusions of this study: (1) FDX1 is highly expressed in gliomas and associated with poor prognosis in low-grade gliomas (LGG). (2) Gene annotation indicates that FDX1 is mainly involved in the tumor protein lipoylation and cell death. (3) FDX1 expression is positively correlated with the infiltration of immune cells. (4) LIPT2 and NNAT, two other genes involved in lipoylation, may be unidentified marker gene for Cuproptosis. And the Cuproptosis genes related to FDX1 were positively correlated with the expression of autophagy marker genes Atg5, Atg12, and BECN-1. This evidence suggests that there may be some interaction between FDX1 mediated Cuproptosis and autophagy. In summary, FDX1 may serve as a potential immunotherapy target and prognostic marker for Glioma.</p

Data_Sheet_2_Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma.CSV

Recent studies have found that the protein encoded by the FDX1 gene is involved in mediating Cuproptosis as a regulator of protein lipoylation and related to immune response process of tumors. However, the specific biological function of FDX1 in glioma is currently unclear. To explore the potential function of FDX1, this study explored the correlation between the expression of FDX1 in cancers and survival prognosis by analyzing the public databases of GEPIA and Cbioportal. Immune infiltration was analyzed by the TIMER2.0 database in tumors. The possible biological processes and functions of FDX1-related in glioma were annotated through gene enrichment. Relationship between Cuproptosis and autophagy was explored through gene co-expression studies. Summary and conclusions of this study: (1) FDX1 is highly expressed in gliomas and associated with poor prognosis in low-grade gliomas (LGG). (2) Gene annotation indicates that FDX1 is mainly involved in the tumor protein lipoylation and cell death. (3) FDX1 expression is positively correlated with the infiltration of immune cells. (4) LIPT2 and NNAT, two other genes involved in lipoylation, may be unidentified marker gene for Cuproptosis. And the Cuproptosis genes related to FDX1 were positively correlated with the expression of autophagy marker genes Atg5, Atg12, and BECN-1. This evidence suggests that there may be some interaction between FDX1 mediated Cuproptosis and autophagy. In summary, FDX1 may serve as a potential immunotherapy target and prognostic marker for Glioma.</p

An Improved and Practical Synthesis of Tranexamic Acid

Tranexamic acid <b>1</b>, a synthetic antifibrinolytic drug with the treatment being considered highly cost-effective in many countries, has been included in the WHO list of essential medicines. In this paper, we designed the synthesis of <b>1</b> via a novel seven-step route from the readily available starting material dimethyl terephthalate, performing with 99.6% purity in 59.2% overall yield. During the process, we successfully developed a direct and efficient method for the preparation of key intermediate methyl 4-(acetamidomethyl)­benzoate by one-pot hydrogenation and acylation in acetic anhydride using Ni/Al₂O₃ as a catalyst. More importantly, it should be a straightforward and practical way to circumvent the usage of toxic reagents (CrO₃, Cl₂), solvent (CCl₄), and expensive catalyst (PtO₂), etc., that plagued the previous methodologies

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Relationship between the 72-h postoperative uKIM-1 level and renal prognosis.

<p>uKIM-1>96.69 pg/mg Cr was significantly correlated with poor prognosis.</p

Relevant risk factors influencing the long-term renal prognosis of patients.

<p>Relevant risk factors influencing the long-term renal prognosis of patients.</p

Distribution of biomarker levels in the deteriorated renal function group and the stable group at 1-year follow-up.

<p>A. Distribution of 72-h postoperative uKIM-1 levels in the deteriorated renal function group and the stable group at 1-year follow-up. B. Distribution of preoperative uL-FABP levels in the deteriorated renal function group and the stable group at 1-year follow-up. C. Distribution of 48-h postoperative uL-FABP levels in the deteriorated renal function group and the stable group at 1-year follow-up. D. Distribution of 72-h postoperative uL-FABP levels in the deteriorated renal function group and the stable group at 1-year follow-up. E. Distribution of preoperative uNGAL levels in the deteriorated renal function group and the stable group at 1-year follow-up.</p

Comparison of the deteriorated renal function group and the stable group at 1-year follow-up.

<p>*The differences between the deteriorated renal function group and the stable group were statistically significant (P<0.05).</p