miRNAs that are dysregulated in cancer tissues compared with normal controls by non-paired t-test that have rarely been mentioned in the literature.

<p>miRNAs that are dysregulated in cancer tissues compared with normal controls by non-paired t-test that have rarely been mentioned in the literature.</p

miRNAs that are Dysregulated in cancer correlated with cancer differentiation.

<p>(A) Compared with normal tissues, a total of 93 miRNAs that were significantly dysregulated were identified, (B) 58 dysregulated miRNAs were found in moderately differentiated tissues compared with well-differentiated tissues, (C) 32 miRNAs were not only able to identify cancers samples and normal controls, but they were also able to distinguish between well- and moderately differentiated tumors.</p

Evaluation of the potential of miR-4510, miR-99b and miR-4469 as cancer biomarkers.

<p>The results show that miR-4510, miR-99b and miR-4469 are highly likely to be diagnostic markers with high sensitivity and specificity.</p

Clinical and histopathological characteristics of patients.

<p>Clinical and histopathological characteristics of patients.</p

miRNAs that were not only able to distinguish cancer patients from normal controls but also able to distinguish well-differentiated and moderately differentiated cancers.

<p>miRNAs that were not only able to distinguish cancer patients from normal controls but also able to distinguish well-differentiated and moderately differentiated cancers.</p

Analysis of the expression levels of miR-1, miR-145*, miR-4510 and miR-4469 between well- and moderately differentiated tumors according to a non-paired t-test.

<p>The results show no obvious differences in the expression levels of miR-1, miR-145*, miR-4510 and miR-4469 between well- and moderately differentiated tumors (<i>P</i>>0.05).</p

Expression levels of miR-1, miR-145, miR-145*, miR-99b, miR-4510, and miR-4469 in an independent sample test.

<p>Expression levels of miR-1, miR-145, miR-145*, miR-99b, miR-4510, and miR-4469 in an independent sample test.</p

Dysregulated miRNAs in cancer tissues compared with normal controls by non-paired t-test.

<p>Dysregulated miRNAs in cancer tissues compared with normal controls by non-paired t-test.</p

Analysis of the correlation of dysregulated miRNAs (miR-145 and miR-99b) according to the degree of tumor differentiation.

<p>The results of the ROC analysis show that miR-145 and miR-99b could not only distinguish cancer samples from normal control samples but also identify well- and moderately differentiated tumors with high sensitivity and specificity.</p

miRNAs that could be used to distinguish well- differentiated and moderately differentiated cancers.

<p>miRNAs that could be used to distinguish well- differentiated and moderately differentiated cancers.</p