1 research outputs found
Synthesis of 3‑Iminoindol-2-amines and Cyclic Enaminones via Palladium-Catalyzed Isocyanide Insertion-Cyclization
A palladium-catalyzed
isocyanide insertion-cyclization using low-cost
and readily accessible 2-haloanilines, 2-iodophenylethanones, and
isocyanides for efficient synthesis of 3-iminoindol-2-amine and cyclic
enaminone derivatives has been developed. The method features low-cost
and readily accessible starting materials, reliable scalability, and
bond-forming efficiency as well as simple one-pot operation, which
makes this strategy highly attractive. A reasonable mechanism for
forming 3-iminoindol-2-amine involved double isocyanide insertion/cyclization
process is proposed