Rapidity bin multiplicity correlations from a multi-phase transport model

The central-arbitrary bin and forward-backward bin multiplicity correlation patterns for Au+Au collisions at $\sqrt{s_{NN}}$= $7.7-62.4$ GeV are investigated within a multi-phase transport (AMPT) model. An interesting observation is that for $\sqrt{s_{NN}} <19.6$ GeV Au+Au collisions, these two correlation patterns both have an increase with the pseudorapidity gap, while for $\sqrt{s_{NN}} >19.6$ GeV Au+Au collisions, they decrease. We mainly discuss the influence of different evolution stages of collision system on the central-arbitrary bin correlations, such as the initial conditions, partonic scatterings, hadronization scheme and hadronic scatterings. Our results show that the central-arbitrary bin multiplicity correlations have different responses to partonic phase and hadronic phase, which can be suggested as a good probe to explore the dynamical evolution mechanism of the hot dense matter in high-energy heavy-ion collisions.Comment: 7pages, 6 figures, accepted for publication in EPJ

Effect of Astragalus membranaceus (Fisch) Bunge extract on streptozocin-induced diabetic in rats

Purpose: To investigate the effect of Astragalus membranaceus (Fisch.) Bunge. extract (AMBE) on streptozotocin-induced diabetic rats.Methods: The aqueous extract of AMB was obtained by steeping the dried  Astragalus membranaceus (Fisch.) Bunge. in water at 60 oC three times, each for 1 h, before first drying in an oven at 100 oC and then freeze-drying the last extract thus obtained. Diabete model rats was induced by a single intraperitoneal injection of a freshly prepared solution of streptozotocin (50 mg/kg). The rats were randomly divided into 6 groups of ten rats each: negative control group, normal control group, reference group (glibenclamide1 mg/kgbody weight) as well as AMB extract groups, namely, 40, 80 and 160 mg/kg body weight. Antihyperglycemic effect was measured by blood glucose and plasma insulin levels. Oxidative stress was evaluated in liver and kidney by antioxidant markers, viz, lipidperoxidation (LPO), superoxide  dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GPx) and catalase (CAT), while blood serum levels of creatinine and urea were also determined in both diabetic control and treated rats.Results: Compared with diabetic rats, oral administration of AMBE at a  concentration of 160 mg/kg daily for 30 days showed a significant decrease in fasting blood glucose (109.438 ± 3.52, p &lt; 0.05) and increased insulin level (13.96 ± 0.74, p &lt; 0.05). Furthermore, it significantly reduced biochemical parameters (serum creatinine, 0.86 ± 0.29, p &lt; 0.05) and serum urea (45.14 ± 1.79, p &lt; 0.05). The treatment also resulted in significant increase in GSH (49.21 ± 2.59, p &lt; 0.05), GPx (11.96 ± 1.16, p &lt; 0.05), SOD (14.13 ± 0.49, p &lt; 0.05), CAT (83.25 ± 3.14, p &lt; 0.05) level in the liver and kidney of diabetic rats.Conclusion: The results suggest that AMBE may effectively normalize impaired  antioxidant status in streptozotocin-induced diabetes in a dose-dependent manner. AMBE has a protective effect against lipid peroxidation by scavenging free radicals and is thus capable of reducing the risk of diabetic complications.Keywords: Astragalus membranaceus, Diabetic, Antihyperglycemic, Antioxidant Oxidative stress, Fasting blood glucos

Evolution of topological charge through chiral anomaly transport

Built upon the state-of-the-art model a multiphase transport (AMPT), we develop a new module of chiral anomaly transport (CAT), which can trace the evolution of the initial topological charge of gauge field created through sphaleron transition at finite temperature and external magnetic field in heavy ion collisions. The eventual experimental signals of chiral magnetic effect(CME) can be measured. The CAT explicitly shows the generation and evolution of the charge separation, and the signals of CME through the CAT are quantitatively in agreement with the experimental measurements in Au+Au collision at $\sqrt{s}=200 {\rm GeV}$, and the centrality dependence of the CME fraction follows that of the fireball temperature.Comment: 7 pages, 6 figure

The Role of the Lactadherin in Promoting Intestinal DCs Development In Vivo and Vitro

Lactadherin, as one of the immune components in the breast milk, might play a role in the intestinal immune system of newborn. Therefore, we investigated the effect of lactadherin-feeding in early time on the development of intestinal immune system compared with naturally rearing and artificially rearing (non-lactadherin). In the present study, we observed that the Peyer's Patches (PP) from the pups of artificially reared group with lactadherin added were characterized by an excess of OX62+CD4+SIRP+ DC cells and a higher expression of CD3+CD4+CD25+T cells. Additionally, this study also demonstrated that IL-10 production was dramatically increased when lactadherin was present in culture medium compared with lactadherin-absent culture. These results suggested that lactadherin could adjust intestinal DCs activity, induce CD3+CD4+CD25+T cell differentiation, and enhance IL-10 production

Structure characterization and antioxidant properties of proteins extracted from the larva of Bombyx mori L.

Purpose: To explore the structural characteristics and antioxidant properties of proteins extracted by salt extraction and ammonium sulfate precipitation (SEAP) from the larvae of Bombyx mori L. (PLB) that died due to infection with Beauveria bassiana (Bals.) Vuill.Methods: The extraction yield of PLB was measured, and protein patterns were examined by SDSPAGE. The amino acid composition of PLB was analyzed using an automatic amino acid analyzer while the structural characteristics of PLB were analyzed by Fourier transform infrared (FT-IR) and UV techniques. In addition, the antioxidant properties of PLB were investigated in vitro.Results: The extraction yield of PLB was 2.16 ± 0.04 %. PLB protein was mainly present in 10 – 20 and 25 – 35 kDa fractions. PLB consisted of 15 types of amino acids. Glu (12.45 ± 0.06), Ala (6.87 ± 0.11) and Val (4.55 ± 0.11) contents of PLB were significantly (p &lt; 0.05) higher relative to that of other amino acids. PLB exhibited the FT-IR and UV spectra characteristics of proteins. In addition, PLB exhibited significant antioxidant effects (p &lt; 0.05).Conclusion: The results indicate that PLB exhibits significant antioxidant effects and may be suitable for development into antioxidant drugs.Keywords: Bombyx mori L., Proteins, Structural characteristics, Antioxidant, Beauveria bassian

Antibacterial Activity and Mode of Action of Mentha arvensis Ethanol Extract against Multidrug-Resistant Acinetobacter baumannii

Purpose: To evaluate the antibacterial effect of ethanol extract of Mentha arvensis against multi-drug resistant Acinetobacter baumannii using liquid chromatography–mass spectrometry (LC-ESI-MS).Methods: Disc diffusion and microdilution assays were used to evaluate the antibacterial effect of the extract by measuring the zone of inhibition, minimum inhibitory concentration (MIC) and and minimum bacteriocidal concentration (MBC) of the extract against the test bacteria. Scanning electron microscopy (SEM) was employed to evaluate the morphological changes induced by the extract in cellular membrane of the bacteria. Reactive oxygen species (ROS) generation and protein leakage from the bacterial cells induced by the extract were also evaluated.Results: The extract showed dose-dependent growth inhibitory effects against A. baumannii with MIC and MBC of 23.5 and 72.1 μg/mL, respectively. The extract also induced potent ROS generation and protein leakage in A. baumannii bacterial cells. SEM findings revealed that the extract induced potential cellular damage which increased with increasing extract concentration.Conclusion: The ethanol extract of Mentha arvensis is a potent antibacterial agent against A. baumannii and acts by inducing lethal cellular damage to the bacterium.Keywords: Mentha arvensis, Acinetobacter baumannii, Reactive oxygen species, Antibacterial activity, Cellular membrane damag

Human Papillomaviruses and Papillomatosis Lesions of the Female Lower Genital Tract

Objective: The objective of this study was to determine whether human papillomavirus (HPV) infections are involved in the development of papillomatosis lesions of the lower female genital tract