Comparison of baseline characteristics according to the presence and severity of coronary atherosclerosis.

<p>Data are expressed as n (%), mean± SD or median (25th–75th percentile). BMI =  Body mass index; CAD =  Coronary artery disease; TG =  Triglyceride; TC =  Total cholesterol; LDL-C =  Low-density lipoprotein-cholesterol; HDL-C =  High-density lipoprotein-cholesterol; LP(a) =  Lipoprotein(a); FFA =  Free fatty acid; ApoA1 =  Apolipoprotein A1; ApoB =  Apolipoprotein B; LVEF  =  Left ventricular ejection fraction; HbA1c =  Glycosylated hemoglobinA1C; hs-CRP =  High sensitivity C-reactive protein; WBCC =  White blood cell count; ESR =  Erythrocyte sedimentation rate; ACEI =  Angiotensin converting enzyme inhibitors; ARB =  Angiotensin receptor blocker.</p>a<p>p<0.05 for coronary stenosis vs. no stenosis.</p>b<p>p<0.01 for coronary stenosis vs. no stenosis.</p>c<p>p<0.05 for high GS vs. low GS.</p>d<p>p<0.01 for high GS vs. low GS.</p><p>Comparison of baseline characteristics according to the presence and severity of coronary atherosclerosis.</p

Regression analyses to assess the severity of coronary atherosclerosis according to fibrinogen tertiles.

<p>Logistic regression analyses are used. Bold values indicate statistical significance. The adjusting known confounders include age, gender, BMI, current smoking, hypertension, family history of CAD, fasting blood glucose, TG, LDL-C, HDL-C and hs-CRP. BMI =  Body mass index; CAD =  Coronary artery disease; TG =  Triglyceride; LDL-C =  Low-density lipoprotein-cholesterol; HDL-C =  High-density lipoprotein-cholesterol; hs-CRP =  High sensitivity C-reactive protein; GS =  Gensini score.</p><p>Regression analyses to assess the severity of coronary atherosclerosis according to fibrinogen tertiles.</p

Regression analyses to determine the independent predictor of high Gensini Score.

<p>Logistic regression analyses are performed. Bold values indicate statistical significance. Co-variates are included age, gender, BMI, current smoking, hypertension, family history of CAD, fasting blood glucose, TG, LDL-C, HDL-C and hs-CRP. ESR =  Erythrocyte sedimentation rate; WBCC =  White blood cell count; LP(a) =  Lipoprotein(a); LVEF  =  Left ventricular ejection fraction; HbA1c =  Glycosylated hemoglobinA1C; BMI =  Body mass index; CAD =  Coronary artery disease; TG =  Triglyceride; LDL-C =  Low-density lipoprotein-cholesterol; HDL-C =  High-density lipoprotein-cholesterol; hs-CRP =  High sensitivity C-reactive protein.</p><p>Regression analyses to determine the independent predictor of high Gensini Score.</p

The levels of fibrinogen and other non-specific inflammatory markers according to the numbers of stenotic vessels (A: Fibrinogen; B: ESR; C: WBCC; D: hs-CRP; E: D-Dimer; F: Table shows data from figure above, presented as mean± SD or median (25th-75th percentile)).

<p>ESR = Erythrocyte sedimentation rate; WBCC = White blood cell count; hs-CRP = High sensitivity C-reactive protein.</p

The presence and severity of coronary atherosclerosis according to fibrinogen tertiles.

<p>Data are expressed as n (%), mean± SD or median (25th–75th percentile). Bold values indicate statistical significance. BMI =  Body mass index.</p><p>The presence and severity of coronary atherosclerosis according to fibrinogen tertiles.</p

The 10-year Framingham risk in 3 subgroups of patients.

<p>The risk is lower in individuals with both CACS = 0 and Tertile 1 of Big ET-1. Group A: CACS = 0 and Tertile 1 of Big ET-1; Group C: CACS >0 and Tertile 3 of Big ET-1; Group B: Others.</p

The correlations of fibrinogen level with Gensini score, hs-CRP, TC and LDL-C concentrations in patients with coronary atherosclerosis (A: Gensini score; B: hs-CRP; C: TC; D: LDL-C).

<p>hs-CRP =  High sensitivity C-reactive protein; TC =  Total cholesterol; LDL-C =  Low-density lipoprotein -cholesterol.</p

The distribution of subjects in high (≥3.21 g/L) or low (<3.21 g/L) fibrinogen groups according to the coronary stenosis and Gensini score.

<p>The distribution of subjects in high (≥3.21 g/L) or low (<3.21 g/L) fibrinogen groups according to the coronary stenosis and Gensini score.</p

Baseline characteristics in patients with unadjusted risk factor levels according to plasma Big ET-1 concentration tertiles.

<p>Baseline characteristics in patients with unadjusted risk factor levels according to plasma Big ET-1 concentration tertiles.</p

The cut-off value of fibrinogen and other non-specific inflammatory markers (hs-CRP, WBCC, ESR and D-dimer) in predicting the severity of coronary atherosclerosis.

<p>hs-CRP =  High sensitivity C-reactive protein; WBCC =  White blood cell count; ESR =  Erythrocyte sedimentation rate.</p