5‑Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties

Two 1-(4-aryl-5-alkyl-pyridin-2-yl)-3-methylurea glucokinase activators were identified with robust <i>in vivo</i> efficacy. These two compounds possessed higher solubilities than the previously identified triaryl compounds (i.e., <b>AM-2394</b>). Structure–activity relationship studies are presented along with relevant pharmacokinetic and <i>in vivo</i> data