pH-sensitive Hybrid Hydrogel Materials with Incorporated Nanoparticles

Synthesis and physico-chemical studies of new promising hybrid hydrogels based on polyvinyl alcohol (PVA) acetales and copolymer hydrogels based on vinyl monomers have been studied. Acrylamide, N-Isopropylacrylamide and Acrylic acid were used as components of interpenetrating networks based on PVA acetals. Sponge acetales of polyvinyl alcohol were used as enforcing net. Study of swelling kinetics as compared to solvents of various nature (water in various pH, ethanol, toluene etc) was carried out. IR comparative spectra were obtained for different composites. High anti-bacterial action of the synthesized nanocomposites containing silver towards gram-positive and gram-negative bacteria has been demonstrated

Nano-Sized Hydrogel Composites Based on N-Isopropylacrylamide and Magnetite for Controlled Drug Delivery

Synthesis and characterization studies of promising nano-sized hydrogel composites based on nisopropylacrylamide and magnetite have been studied. N-isopropylacrylamide (NIPA) gel component was used as a carrier of various drugs, magnetite was used as a magneto-responsive component. Presence of magnetite it was proved by EPR method. Composite nanoparticles were characterized by electron microscopy (TEM) and by dynamyc light scattering (DLS) method. It was shown that the average size of nanoparticles is 50 or 100 nm, depending on the method of preparation. The hydrogel is characterized by clear phase transition between swollen and collapsed state upon heating above 32⁰C. Rapid release of the incorporated drug (as a model was used the photosensibilizer -Methylene Blue) observed during thermoresponsive nanocomposite gels heating in the physiologically acceptable range, but still above phase transition temperature (up to 40–50 ⁰C), allows application of the discussed drug delivery systems in medical hyperthermia

Thermo- and pH-sensitive Hydrogels with Incorporated Multi-Walled Carbon Nanotubes

Carbon nanotubes (CNTs) attract great attention due to the unique combination of physical, chemical, electrical and mechanical properties which have high potential for design of nanocomposite materials with customized properties (electromagnetic shielding, high strength and electroconductivity materials), actua-tors (e.g. artificial muscles and tissues), sensors, components of microfluidic devices, etc. Usage of CNT in practical applications is limited by their lower solubility in most solvents. Remaining primary agglomer-ates of NT not only increase the amount of filler needed for percolation, but also act as imperfections under mechanical stress. Therefore, in this investigation, the influence of surfactant type and its concentration, along with sonication treating time on sedimentation behavior of multi-walled carbon nanotubes was in-vestigated. To a greater extent, the influence of monomer composition, surface-active substances, and car-bon nanotubes on gelation and physicochemical properties of thermo- and pH-sensitive hydrogels and hy-drogel nanocomposites based on N-isopropylacrylamide with carbon nanotubes were investigated too. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3559

Nano-Sized Hydrogel Composites Based on N-Isopropylacrylamide and Magnetite for Controlled Drug Delivery

Synthesis and characterization studies of promising nano-sized hydrogel composites based on nisopropylacrylamide and magnetite have been studied. N-isopropylacrylamide (NIPA) gel component was used as a carrier of various drugs, magnetite was used as a magneto-responsive component. Presence of magnetite it was proved by EPR method. Composite nanoparticles were characterized by electron microscopy (TEM) and by dynamyc light scattering (DLS) method. It was shown that the average size of nanoparticles is 50 or 100 nm, depending on the method of preparation. The hydrogel is characterized by clear phase transition between swollen and collapsed state upon heating above 32⁰C. Rapid release of the incorporated drug (as a model was used the photosensibilizer -Methylene Blue) observed during thermoresponsive nanocomposite gels heating in the physiologically acceptable range, but still above phase transition temperature (up to 40–50 ⁰C), allows application of the discussed drug delivery systems in medical hyperthermia

Thermosensitive Hydrogels and Microgels Based on N-isopropylacrylamide and Acrylamide with Incorporated Magnetite

Hydrogels with magnetic properties (ferrogels) are very promising for medical application, first of all, for the design of targeted delivery systems with controlled release of drugs and for magnetic hyperthermia and could be obtained using different techniques (ex- and in-situ syntheses). The present work is devoted to the study of magnetite (Fe3O4) formation inside the nanoreactors of (co)polymeric gels (hydrogels and mi-crogels) based on the derivatives of acrylic acid: N-isopropylacrylamide, acrylamide, and N,N-methylenbisacrylamide (crosslinking agent). Influence of hydrophilic–lipophilic balance of (co)polymeric templates, temperature, pH and concentration of iron cations on the magnetite formation inside polymeric matrixes were investigated along with the development of ferrogel preparation technique. Physical and chemical properties of obtained ferrogels have been studied with gravimetric analysis, thermogravimetric analysis, X-ray fluorescence spectroscopy, X-ray diffraction, optical and transmission microscopies, IR spec-troscopy, etc. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3544

Hybrid Hydrogel Materials with Incorporated Nanoparticles

Synthesis and physico-chemical studies of new promising hybrid hydrogels based on polyvinyl alcohol (PVA) acetales and copolymer hydrogels based on vynil monomers have been studied. Acrylamide and Acrylnitrile were used as some of components that carry various fillers . Sponge acetales of polyvinyl alco-hol were used as enforcing net. The synthesized composites demonstrated high strength as compared to standard hydrogels- Yung-module varied in the range of 80 to 300 kPa depending on the extent of PVA ac-etale matrix filling with hydrogel component. The materials showed high sorbability to water and water solutions. Study of swelling kinetics as compared to solvents of various nature (water, ethanol, sunflower oil ) was carried out. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3546