Morphological prerequisites for the formation of fascial duplication in the elimination of damage to the anterior rectal wall during prostatectomy

Background Intraoperative rectal injury in prostatectomy patients is an uncommon but severe complication. Particular attention is paid to improving the results of healing damage to the anterior rectal wall during prostatectomy.Objective To study the morphological features of the parietal pelvic fascia and the rectal wall to substantiate the possibility of the formation of fascial duplication in the elimination of damage to the anterior rectal wall during prostatectomy.Material and Methods The authors carried out an intravital morphological analysis of the parietal pelvic fascia covering the levator rectum muscle and the anterior rectal wall in 10 men.Results The parietal pelvic fascia contains more powerful bundles of collagen fibers, which in certain areas are partially woven into the fibers of striated muscle tissue. The adventitia of the rectum is characterized by a looser arrangement of the interacting components of the formed connective and smooth muscle tissue. In the studied formations of the small pelvis, the thickness of collagen fibers separately and in the composition of bundles, as well as the cells of the differon and each fiber separately did not differ, which indicated the identity of their tinctorial properties in the compared zones.Conclusion Morphological analysis showed that when juxtaposing and touching the edges of the healing area of the surgical wound without tension, a stable and continuous scar of the fascial duplication is formed, which ensures reliable fusion of the stitched anatomical structures

Состояние онкологической помощи больным раком предстательной железы в Омской области в 2005-2010 гг.

Objective: to study the frequency and dynamics of morbidity and mortality in male population of Omsk region with prostate cancerfor the period from 2005 to 2010.Materials and methods. A retrospective analysis was carried out for the periodfrom 2005 to 2010 of the initial diagnosis of1840patients with prostate cancer and the causes of death of837men in the Omsk region. The contingents of patients with prostate cancer were studied depending on the geographic location, size and composition of the region’s population. The data of the updated base of the population cancer registry and the main reporting forms were used.Results. There was an increase in the absolute number of diagnosed patients with prostate cancer for the first time by an average of 9.9 % annually. The downward trend was in the number of patients with I—II tumor stage lesions. Stable high annual detection of patients was with stage III (more than 50 %). The advanced forms of prostate cancer accounted for up to 24.4 %. The absolute number of men registered had increased by 52.4 %. The annual mortality rate decreased by an average of 5.7 %. During the monitoring period the absolute number of dead patients increased by an average of 6.7 % annually.Conclusion. The development and regional implementation of the Program for the early diagnosis and screening of prostate cancer based on a set of simple and generally accessible methods is advisable.Цель исследования — изучить частоту и динамику заболеваемости раком предстательной железы и смертности от данной патологии среди мужского населения Омской области в период с 2005 по 2010 г.Материалы и методы. За период с 2005по 2010 г. проведен ретроспективный анализ первичной диагностики 1840 больных раком предстательной железы и причин смерти 837мужчин в Омской области. Изучены контингенты больных раком предстательной железы в зависимости от географического положения, численности и состава населения региона. Использовали данные уточненной базы популяционного ракового регистра и основные отчетные формы.Результаты. Отмечено увеличение абсолютного числа вновь выявленных больных раком предстательной железы в среднем на 9,9 % ежегодно. Наблюдалась тенденция к снижению числа больных с I—II стадиями опухолевого поражения. Отмечено стабильно высокое (более 50 %) ежегодное выявление пациентов с III стадией. Запущенные формы рака предстательной железы составляли до 24,4 %. На 52,4 % увеличилось абсолютное число мужчин, состоящих на учете. Показатель годичной летальности снизился в среднем на 5,7 %. За период наблюдения увеличилось абсолютное число умерших пациентов в среднем на 6,7 % ежегодно.Заключение. Целесообразны разработка и региональное внедрение Программы ранней диагностики и скрининга рака предстательной железы на основании комплекса простых и общедоступных методов

The Complete Genome Sequence of ‘Candidatus Liberibacter solanacearum’, the Bacterium Associated with Potato Zebra Chip Disease

Zebra Chip (ZC) is an emerging plant disease that causes aboveground decline of potato shoots and generally results in unusable tubers. This disease has led to multi-million dollar losses for growers in the central and western United States over the past decade and impacts the livelihood of potato farmers in Mexico and New Zealand. ZC is associated with ‘Candidatus Liberibacter solanacearum’, a fastidious alpha-proteobacterium that is transmitted by a phloem-feeding psyllid vector, Bactericera cockerelli Sulc. Research on this disease has been hampered by a lack of robust culture methods and paucity of genome sequence information for ‘Ca. L. solanacearum’. Here we present the sequence of the 1.26 Mbp metagenome of ‘Ca. L. solanacearum’, based on DNA isolated from potato psyllids. The coding inventory of the ‘Ca. L. solanacearum’ genome was analyzed and compared to related Rhizobiaceae to better understand ‘Ca. L. solanacearum’ physiology and identify potential targets to develop improved treatment strategies. This analysis revealed a number of unique transporters and pathways, all potentially contributing to ZC pathogenesis. Some of these factors may have been acquired through horizontal gene transfer. Taxonomically, ‘Ca. L. solanacearum’ is related to ‘Ca. L. asiaticus’, a suspected causative agent of citrus huanglongbing, yet many genome rearrangements and several gene gains/losses are evident when comparing these two Liberibacter. species. Relative to ‘Ca. L. asiaticus’, ‘Ca. L. solanacearum’ probably has reduced capacity for nucleic acid modification, increased amino acid and vitamin biosynthesis functionalities, and gained a high-affinity iron transport system characteristic of several pathogenic microbes

The prevalence of prostate cancer from 2005 to 2010 in terms of patient survival

Objective: to study the frequency and dynamics of morbidity and mortality in male population of Omsk region with prostate cancerfor the period from 2005 to 2010.Materials and methods. A retrospective analysis was carried out for the periodfrom 2005 to 2010 of the initial diagnosis of1840patients with prostate cancer and the causes of death of837men in the Omsk region. The contingents of patients with prostate cancer were studied depending on the geographic location, size and composition of the region’s population. The data of the updated base of the population cancer registry and the main reporting forms were used.Results. There was an increase in the absolute number of diagnosed patients with prostate cancer for the first time by an average of 9.9 % annually. The downward trend was in the number of patients with I—II tumor stage lesions. Stable high annual detection of patients was with stage III (more than 50 %). The advanced forms of prostate cancer accounted for up to 24.4 %. The absolute number of men registered had increased by 52.4 %. The annual mortality rate decreased by an average of 5.7 %. During the monitoring period the absolute number of dead patients increased by an average of 6.7 % annually.Conclusion. The development and regional implementation of the Program for the early diagnosis and screening of prostate cancer based on a set of simple and generally accessible methods is advisable