28 research outputs found
STRUCTURE, PHYSICAL AND MECHANICAL PROPERTIES OF ALUMINIUM-GADOLYNIUM MASTER ALLOYS OBTAINED BY EXCHANGE PROCESSES
The exchange reaction between aluminum metal and gadolinium fluoride is proposed for Gd-Al master alloy synthesis. The structure on the synthesized alloys with different gadolinium concentration was investigated. It was shown that Al and Al3Gd are the main phases in the alloys. Mechanical and thermophysical properties of the obtained masteralloys were measured
STRUCTURE, PHYSICAL AND MECHANICAL PROPERTIES OF ALUMINIUM-REE MASTER ALLOYS OBTAINED BY EXCHANGE PROCESSES
The exchange reactions between aluminum metal and REE fluorides are proposed for Al-REE master alloy synthesis. The structure on the synthesized alloys with different gadolinium concentration was investigated. It was shown that Al and Al3REE are the main phases in the alloys. Mechanical and thermophysical properties of the obtained master-alloys were measured
CONSTRUCTION OF «TIME – TEMPERATURE – PRECIPITATION» DIAGRAM FOR KHN62M ALLOY WITH LOW CARBON CONTENT
The thermal stability of KhN63M alloy with low carbon content was investigated. It was shown that formation of carbide phases does not take place. Phase structure of excessive carbide phases was characterized. The constructed «time – temperature – precipitation» diagram allows to determine the maximal temperature and time of alloy’s operation in contact with molten salts
CONSTRUCTION OF «TIME – TEMPERATURE – PRECIPITATION» DIAGRAM FOR MODIFIED KHN63MB ALLOY WITH LOW CARBON CONTENT
The thermal stability of KhN63MB alloy with low carbon content was investigated. It was shown that formation of carbide phases does not take place. Phase structure of excessive carbide phases was characterized. The constructed «time – temperature – precipitation» diagram allows to determine the maximal temperature and time of alloy’s operation in contact with molten salts
CORROSION, MECHANICAL AND THERMOPHYSICALPROPERTIES OF THE NEW ALLOY ON THE BASIS OF THE SYSTEM «Ni-Cr-Mo» WITH A LOW CARBON CONTENT
The mechanical and thermophysical properties as well as the tendency to intergranular corrosion of the new nickel alloy with low carbon content were investigated. It was found that Physical and mechanical properties of the prepared alloy under high temperature conditions are influenced by changes of structure and composition. In separate series of experiments corrosion resistance of the material was studied in a wide temperature range (450 – 650 °C) in the molten chloroaluminate melts. The rates and the mechanisms of corrosion of the studied materials were determined. The processes taking place during the interaction between metals and melts were investigated
Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats
The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key
regulator of metabolism, stress resistance and longevity. Apart from its role as
an important redox carrier, NAD+ also serves as the sole substrate for
NAD-dependent enzymes, including poly(ADP-ribose) polymerase (PARP), an
important DNA nick sensor, and NAD-dependent histone deacetylases, Sirtuins
which play an important role in a wide variety of processes, including
senescence, apoptosis, differentiation, and aging. We examined the effect of
aging on intracellular NAD+ metabolism in the whole heart, lung, liver and
kidney of female wistar rats. Our results are the first to show a significant
decline in intracellular NAD+ levels and NAD∶NADH ratio in all organs
by middle age (i.e.12 months) compared to young (i.e. 3 month old) rats. These
changes in [NAD(H)] occurred in parallel with an increase in lipid
peroxidation and protein carbonyls (o- and m- tyrosine) formation and decline in
total antioxidant capacity in these organs. An age dependent increase in DNA
damage (phosphorylated H2AX) was also observed in these same organs. Decreased
Sirt1 activity and increased acetylated p53 were observed in organ tissues in
parallel with the drop in NAD+ and moderate over-expression of Sirt1
protein. Reduced mitochondrial activity of complex I–IV was also observed
in aging animals, impacting both redox status and ATP production. The strong
positive correlation observed between DNA damage associated NAD+ depletion
and Sirt1 activity suggests that adequate NAD+ concentrations may be an
important longevity assurance factor
CORROSION, MECHANICAL AND THERMOPHYSICAL PROPERTIES OF THE NEW ALLOY KHN62M
The mechanical and thermophysical properties as well as the tendency to intergranular corrosion of the new nickel alloy with low carbon content were investigated. It was found that physical and mechanical properties of the prepared alloy under high temperature conditions are influenced by changes of structure and composition. In separate series of experiments corrosion resistance of the material was studied in a wide temperature range (450 – 650 °C) in the molten chloroaluminate melts. The rates and the mechanisms of corrosion of the studied materials were determined. The processes taking place during the interaction between metals and melts were investigated
Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform
Currently, there is no available needle-free approach for diabetics to monitor glucose levels in the interstitial fluid. Here, we report a path-selective, non-invasive, transdermal glucose monitoring system based on a miniaturized pixel array platform (realized either by graphene-based thin-film technology, or screen-printing). The system samples glucose from the interstitial fluid via electroosmotic extraction through individual, privileged, follicular pathways in the skin, accessible via the pixels of the array. A proof of principle using mammalian skin ex vivo is demonstrated for specific and ‘quantized’ glucose extraction/detection via follicular pathways, and across the hypo- to hyper-glycaemic range in humans. Furthermore, the quantification of follicular and non-follicular glucose extraction fluxes is clearly shown. In vivo continuous monitoring of interstitial fluid-borne glucose with the pixel array was able to track blood sugar in healthy human subjects. This approach paves the way to clinically relevant glucose detection in diabetics without the need for invasive, finger-stick blood sampling