ОЦЕНКА МЕДИКО-ДЕМОГРАФИЧЕСКИХ ПОТЕРЬ НАСЕЛЕНИЯ КРАСНОЯРСКОГО КРАЯ ОТ СМЕРТНОСТИ, ОБУСЛОВЛЕНОЙ РАКОМ ПОЧКИ

In the article the characteristic of medico-demographic deaths caused by renal cancer among the population of Krasnoyarsk region is given. There are results of research with use of modern approaches of losses of health definition. The evaluation of medico-demographic deaths caused by renal cancer among the population of Krasnoyarsk region for the period 2010–2012 with using DALY method was produced. The largest difference in values of the indicator DALY was observed between male and female population in 2011 by a factor of 4,7. The maximum gap in DALY indicator between male and female population was observed in the group of 55–59 years. More than half of DALY deaths among male involve working ageДана характеристика медико-демографических потерь от рака почки среди населения Красноярского края. Отражены результаты исследования с использованием современных подходов определения потерь здоровья. Произведена оценка медико-демографических потерь населения Красноярского края за период 2010–2012 гг. по методике DALY, обусловленных раком почки. Наибольшая разница в значениях показателя DALY между мужским и женским населением отмечалась в 2011 г. – в 4,7 раза. Максимальный разрыв в показателях DALY между мужским и женским населением отмечен в группе 55–59 лет. Более половины потерь DALY среди мужчин приходится на трудоспособный возраст

Зависимость уровня белка-транслокатора TSPO и цитохрома Р450SCC от гистотипа опухоли у больных почечно-клеточным раком

The features of expression of translocator protein (TSPO) and cytochrome P450scc (CYP 450scc) in patients with renal cell carcinoma (RCC) were described in the article. The dependence of level expression of TSPO from stage and histological subtypes of renal cell carcinoma were established. The changing of expression level of CYP 450scc in tumor cells indicates a change of severity of steroidogenesis in different histological subtypes of RCC. These findings were important for interpretation the pathogenesis of RCC and also they could have prognostic valueОписаны особенности экспрессии белка-транслокатора (TSPO) и цитохрома P450scc (CYP 450scc) у больных почечно-клеточным раком (ПКР). Установлена зависимость уровня экспрессии TSPO от стадии и гистологического варианта рака почки. Изменение уровня экспрессии CYP 450scc в клетках опухоли свидетельствует об изменении выраженности стероидогенеза при различных гисто- типах ПКР. Полученные данные важны для понимания патогенеза рака почки, а также могут иметь прогностическое значение

КЛИНИЧЕСКИЙ СЛУЧАЙ ГРИБОВИДНОГО МИКОЗА

Mucosis fungoides (Sezary syndrome) is a rare disease. Because of polymorphism of clinical manifestations that mimic benign diseases of the skin, it often takes several years before the disease is diagnosed. The paper presents a clinical case of progressive mucosis fungoides with unfavorable outcome. The diagnosis of mycosis fungoides was first suspected on the basis of laboratory studies of peripheral blood.Грибовидный микоз/синдром Сезари относится к редким заболеваниям. Из-за полиморфизма клинических проявлений, имитирующих доброкачественные заболевания кожи, нередко от момента появления первых симптомов до постановки диагноза проходит несколько лет. Представлен клинический случай прогрессирующего течения грибовидного микоза с неблагоприятным исходом. Диагноз грибовидного микоза впервые был заподозрен на основании лабораторного исследования периферической крови

PROBLEMS OF PARANEOPLASTIC LIMBIC ENCEPHALITIS DIAGNOSIS

Abstract: paraneoplastic limbic encephalitis (PLE) is clinical form of paraneoplastic neurological syndrome, an autoimmune disorder of the central nevrous system. The incidence of PLE is about 3 cases per 1,000 patients with cancer. PLE is characterized by acute or subacute development of memory disorders, symptomatic epilepsy, psychiatric disorders. The authors present the current data on the pathogenesis, clinical presentation, diagnosis, and treatment of PLE, a clinical case of symptomatic epilepsy in the 38-year-old man with PLE associated with testicular cancer

Evaluation of medico-demographic deathsof population in Кrasnoyarsk region caused by renal cancer

In the article the characteristic of medico-demographic deaths caused by renal cancer among the population of Krasnoyarsk region is given. There are results of research with use of modern approaches of losses of health definition. The evaluation of medico-demographic deaths caused by renal cancer among the population of Krasnoyarsk region for the period 2010–2012 with using DALY method was produced. The largest difference in values of the indicator DALY was observed between male and female population in 2011 by a factor of 4,7. The maximum gap in DALY indicator between male and female population was observed in the group of 55–59 years. More than half of DALY deaths among male involve working ag

THE DEPENDENCE OF TRANSLOCATOR PROTEIN TSPO LEVEL AND CYTOCHROME P450SCC FROM HISTOTYPE OF TUMOR IN PATIENTS WITH RENAL CELL CARCINOMA

The features of expression of translocator protein (TSPO) and cytochrome P450scc (CYP 450scc) in patients with renal cell carcinoma (RCC) were described in the article. The dependence of level expression of TSPO from stage and histological subtypes of renal cell carcinoma were established. The changing of expression level of CYP 450scc in tumor cells indicates a change of severity of steroidogenesis in different histological subtypes of RCC. These findings were important for interpretation the pathogenesis of RCC and also they could have prognostic valu

A CLINICAL CASE OF MUCOSIS FUNGOIDES

Mucosis fungoides (Sezary syndrome) is a rare disease. Because of polymorphism of clinical manifestations that mimic benign diseases of the skin, it often takes several years before the disease is diagnosed. The paper presents a clinical case of progressive mucosis fungoides with unfavorable outcome. The diagnosis of mycosis fungoides was first suspected on the basis of laboratory studies of peripheral blood

DIFFERENTIATION OF RETINAL ASTROCYTIC HAMARTOMA FROM OTHER RETINAL NEOPLASMS: A CASE REPORT

Astrocytic retinal hamartoma (phacoma, astrocytoma) is a benign tumor, formed through proliferation of glial astrocytes and blood vessels of the sensory part of the retina. For the first time, eye involvement in tuberous sclerosis (TS) was described by J. van der Hoeva, Dutch ophthalmologist in 1921. A characteristic glial tumor is still considered a classic manifestation of this disease, however, retinal astrocytoma can be observed in practically healthy young people or children. We present the case of a 19-year-old woman diagnosed with multiple retinal hamartomas in the right eye. In addition to ophthalmoscopy, we used the additional diagnostic methods to determine the form of hamartomas (calcined or uncalcined) and differentiate astrocytic retinal hamartoma from other tumors of the retina and choroid as well as to exclude pathological changes in the central nervous system