Treatment of cryptorchidism in pediatric surgical practice: a multicenter study

Introduction. Cryptorchidism is a common disease in pediatric urological and andrological practice since the issues of tactical approaches and its optimal treatment remain extremely relevant. Cryptorchidism makes a significant contribution to the structure of male infertility.Objective. To conduct a retrospective analysis of treatment results in children and adolescents with cryptorchidism.Materials & methods. This study summarises the treatment results of 8308 patients with cryptorchidism aged from 6 months to 17 years who underwent inpatient treatment in the Russian Federation and the Republic of Uzbekistan.Results. It was revealed that from 2015 to 2019, patients were admitted for surgical treatment evenly over the years. The ratio of right-sided / left-sided / bilateral cryptorchidism was 4.6 : 4.4 : 1 The inguinal form prevailed more than 6 times over the abdominal location. At the same time, 26.1% of the patients underwent surgery at the optimal time, and 9.8% were older than 10 years. More often, children are operated from an open inguinal access (95.0%), much less often — laparoscopically and percutaneously. Stage-by-stage treatment was carried out in 6.0% of patients.Conclusion. Thus, the approach presented in the study in the surgical treatment of cryptorchidism provided good treatment results. The number of disease relapses was 1.9% (mainly among children over 7 years old). Most surgeons are very reserved about primary orchidectomies (only 3.8% were performed)

The role of quality management system in the development of Kuban SAU human capital

The article shows the experience of Kuban State Agrarian University in development andimplementation of the quality management system. An approved approach to evaluation of the effectiveness of QMS improvement describing the dynamics of university development is presented

Metal- and Ligand-Supported Reduction of the {Fe₂S₂} Cluster as a Path to Formation of Molecular Group 13 Element Complexes {Fe₂S₂M} (M = Al, Ga)

The first examples of molecular cluster complexes with the Fe₂S₂(CO)₆ moiety covalently bound to the group 13 elements Al and Ga have been synthesized and characterized. The complexes [(Cp*M)­Fe₂(μ₃-S)₂(CO)₆] with M = Al (<b>1</b>), Ga (<b>2</b>) have been synthesized by the reduction of [Fe₂S₂(CO)₆] by the corresponding M­(I) complexes [AlCp*]₄ and [GaCp]. Analogously, upon reduction of [Fe₂S₂(CO)₆] by a Ga­(II) complex, [(dpp-Bian)­Ga]₂ (dpp-Bian = 1,2-bis­{(2,6-diisopropylphenyl)­imino}­acenaphthene), the compound [((dpp-Bian)­Ga)­Fe₂(μ₃-S)₂(CO)₆] (<b>3</b>) is formed. The M atoms in <b>1</b> and <b>2</b> are coordinated by the two S atoms; thus, the fragment Fe₂S₂(CO)₆ is considered to be dianionic. The Cp* moiety is bound differently to the Al (η⁵) and Ga (η²) atoms, which can be rationalized on the basis of DFT calculations showing different orbital structures for the analogous compounds. In compound <b>3</b> the Ga atom is coordinated by the two S atoms as well; therefore, the fragment Fe₂S₂(CO)₆ is considered to be dianionic, while the Bian ligand is radical anionic, as confirmed by the structure, EPR spectra, and DFT. The redox-active Bian ligand thus takes part in the reduction of the Fe₂S₂ cluster and changes its formal charge (−2 → −1), along with the Ga center (+2 → +3). Analogously to <b>3</b>, the Al complex [((dpp-Bian)­Al)­Fe₂(μ₃-S)₂(CO)₆] (<b>4</b>) is formed in solution and detected by EPR, but it is not stable enough to be crystallized. In contrast to the case for <b>1</b> and <b>2</b>, the calculated molecular and electronic structures of <b>3</b> and <b>4</b> are similar

A Case of Laying Hens Mycosis Caused by Fusarium proliferatum

In this article, we present the first case report of a chicken mycosis caused by F. proliferatum occurred on a private farm in the Russian Federation. Lesions on the skin of the legs and scallops were reported. The object of this study was samples of feed and pathological material from sick hens-layers. Mycological analysis included determination of the total number of fungi (TNF) and identification and determination of the toxicity and pathogenicity of the isolates. The identification of the isolate was carried out taking into account direct microscopy, morphological features, and the method of molecular genetic analysis. Microscopic fungi of the genus Penicillium and Rhizopus were isolated by mycological analysis of the feed. The test feed was nontoxic. Mycological examination of pathological material (scrapings from the combs and affected legs) identified an isolate of Fusarium proliferatum, which showed toxicity on biological objects (protozoa, rabbits) and pathogenicity (white mice). Dermal application of F. proliferatum suspension was accompanied by reddening of the rabbit skin. Intraperitoneal injection of fungal spores caused mycosis in white mice. Polymerase chain reaction (PCR) made it possible to identify this type of microscopic fungus (F. proliferatum) with high accuracy in the samples under study. The research results allow us to consider F. proliferatum as a cause of poultry disease against the background of predisposing factors in the form of desquamation of the stratum corneum of the skin against the background of immunosuppression and metabolic disorders caused by an imbalance in the diet