Effect of Electron Energy Distribution Function on Power Deposition and Plasma Density in an Inductively Coupled Discharge at Very Low Pressures

A self-consistent 1-D model was developed to study the effect of the electron energy distribution function (EEDF) on power deposition and plasma density profiles in a planar inductively coupled plasma (ICP) in the non-local regime (pressure < 10 mTorr). The model consisted of three modules: (1) an electron energy distribution function (EEDF) module to compute the non-Maxwellian EEDF, (2) a non-local electron kinetics module to predict the non-local electron conductivity, RF current, electric field and power deposition profiles in the non-uniform plasma, and (3) a heavy species transport module to solve for the ion density and velocity profiles as well as the metastable density. Results using the non-Maxwellian EEDF model were compared with predictions using a Maxwellian EEDF, under otherwise identical conditions. The RF electric field, current, and power deposition profiles were different, especially at 1mTorr, for which the electron effective mean free path was larger than the skin depth. The plasma density predicted by the Maxwellian EEDF was up to 93% larger for the conditions examined. Thus, the non-Maxwellian EEDF must be accounted for in modeling ICPs at very low pressures.Comment: 19 pages submitted to Plasma Sources Sci. Techno

Flame front propagation IV: Random Noise and Pole-Dynamics in Unstable Front Propagation II

The current paper is a corrected version of our previous paper arXiv:adap-org/9608001. Similarly to previous version we investigate the problem of flame propagation. This problem is studied as an example of unstable fronts that wrinkle on many scales. The analytic tool of pole expansion in the complex plane is employed to address the interaction of the unstable growth process with random initial conditions and perturbations. We argue that the effect of random noise is immense and that it can never be neglected in sufficiently large systems. We present simulations that lead to scaling laws for the velocity and acceleration of the front as a function of the system size and the level of noise, and analytic arguments that explain these results in terms of the noisy pole dynamics.This version corrects some very critical errors made in arXiv:adap-org/9608001 and makes more detailed description of excess number of poles in system, number of poles that appear in the system in unit of time, life time of pole. It allows us to understand more correctly dependence of the system parameters on noise than in arXiv:adap-org/9608001Comment: 23 pages, 4 figures,revised, version accepted for publication in journal "Combustion, Explosion and Shock Waves". arXiv admin note: substantial text overlap with arXiv:nlin/0302021, arXiv:adap-org/9608001, arXiv:nlin/030201

Accuracy and variability of acoustic measures of voicing onset

Five commonly used methods for determining the onset of voicing of syllable-initial stop consonants were compared. The speech and glottal activity of 16 native speakers of Cantonese with normal voice quality were investigated during the production of consonant vowel (CV) syllables in Cantonese. Syllables consisted of the initial consonants /ph/, /th/, /kh/, /p/, /t/, and /k/ followed by the vowel /a/. All syllables had a high level tone, and were all real words in Cantonese. Measurements of voicing onset were made based on the onset of periodicity in the acoustic waveform, and on spectrographic measures of the onset of a voicing bar (f0), the onset of the first formant (F1), second formant (F2), and third formant (F3). These measurements were then compared against the onset of glottal opening as determined by electroglottography. Both accuracy and variability of each measure were calculated. Results suggest that the presence of aspiration in a syllable decreased the accuracy and increased the variability of spectrogram-based measurements, but did not strongly affect measurements made from the acoustic waveform. Overall, the acoustic waveform provided the most accurate estimate of voicing onset; measurements made from the amplitude waveform were also the least variable of the five measures. These results can be explained as a consequence of differences in spectral tilt of the voicing source in breathy versus modal phonation. ©2003 Acoustical Society of America.published_or_final_versio

Nonlinear Waves in Bose-Einstein Condensates: Physical Relevance and Mathematical Techniques

The aim of the present review is to introduce the reader to some of the physical notions and of the mathematical methods that are relevant to the study of nonlinear waves in Bose-Einstein Condensates (BECs). Upon introducing the general framework, we discuss the prototypical models that are relevant to this setting for different dimensions and different potentials confining the atoms. We analyze some of the model properties and explore their typical wave solutions (plane wave solutions, bright, dark, gap solitons, as well as vortices). We then offer a collection of mathematical methods that can be used to understand the existence, stability and dynamics of nonlinear waves in such BECs, either directly or starting from different types of limits (e.g., the linear or the nonlinear limit, or the discrete limit of the corresponding equation). Finally, we consider some special topics involving more recent developments, and experimental setups in which there is still considerable need for developing mathematical as well as computational tools.Comment: 69 pages, 10 figures, to appear in Nonlinearity, 2008. V2: new references added, fixed typo

A mobile-based solution for supporting end-users in the composition of services

The final publication is available at Springer via http://dx.doi.org/10.1007/s11042-016-3910-4Currently, technologies and applications evolve to create eco-systems made up of a myriad of heterogeneous and distributed services that are accessible anytime and anywhere. Even though these services can be used individually, it is their coordinated and combined usage what provide an added value to end-users. In addition, user¿s wide adoption of mobile devices for daily activities have fostered a shift in the role played by end-users towards Internet data and services. However, existing solutions to service composition are not targeted to ordinary end-users. More easy-to-use tools have to be offered to end-users to make sure that they are successfully accepted and used by them. To this end, the work presented in this paper supports end-users in the creation of service compositions by using mobile devices. We present a Domain Specific Visual Language (DSVL) for end-users that allows them to create service compositions. A tool specifically designed for mobile devices supports this DSVL.This work has been developed with the support of MINECO under the project SMART ADAPT TIN2013-42981-P and co-financed with ERDF.Valderas Aranda, PJ.; Torres Bosch, MV.; Mansanet Benavent, I.; Pelechano Ferragud, V. (2016). A mobile-based solution for supporting end-users in the composition of services. Multimedia Tools and Applications. 1-31. https://doi.org/10.1007/s11042-016-3910-4S131Athreya B, Bahmani F, Diede A, Scaffidi C (2012) End-user programmers on the loose: a study of programming on the phone for the phone. In IEEE Symposium on Visual Languages and Human-Centric Computing (VL/HCC), Innsbruck, Austria, pp. 75–82Atoma (2015) Atoomam, a touch of magic. Accesible at: https://www.atooma.com/ . Last time accessed: December 2015Ayora C, Torres V, Weber B, Reichert M, Pelechano V (2013) Enhancing modeling and change support for process families through change patterns. In: Enterprise, business-process and information systems modeling. Springer, Berlin, pp. 246–260Boehm B, Abts C, Brown A, Chulani S, Clark B, Horowitz E, Madchy R, Reifer D, Steece B (2000) Software Cost Estimation with COCOMOII. Upper Saddle River: Prentice HallBPDM (2014) Business Process Defintion Metamodel, volume ii: Process Definitions. http://www.omg.org/spec/BPDM/1.0/volume2/PDFCasati F (1998) Models, semantics, and formal methods for the design of workflows and their exceptions. PhD thesis, MilanoCouper MP, Tourangeau R, Conrad FG, Crawford SD (2004) What they see is what we get: response options for web surveys. Soc Sci Comput Rev 22(1):111–127Cuccurullo S, Francese R, Risi M, Tortora G (2011) MicroApps development on mobile phones. In: End-user development. Springer, Berlin, pp. 289–294Dadam P, Reichert M (2009) The ADEPT project: a decade of research and development for robust and flexible process support. Comput Sci - R&D 23:81–97Danado J, Paternò F (2014) Puzzle: a mobile application development environment using a jigsaw metaphor. J Vis Lang Comput 25(4):297–315Danado J, Davies M, Ricca P, Fensel A (2010) An authoring tool for user generated mobile services. In: Future internet-FIS 2010. Springer, Berlin, pp. 118–127Dey AK, Sohn T, Streng S, Kodama J (2006) iCAP: interactive prototyping of context-aware applications. In: Pervasive computing. Springer, Berlin, pp. 254–271Engeström Y, Miettinen R, Punamäki RL (1999) Perspectives on activity theory. Cambridge University Press, CambridgeGalitz WO (2002) The essential guide to user interface design: an introduction to GUI. In: Design principles and techniques. Wiley, New YorkGil M, Serral E, Valderas P, Pelechano V (2013) Designing for user attention: a method for supporting unobtrusive routine tasks. Sci Comput Program 78(10):1987–2008Gubbi J, Buyya R, Marusic S, Palaniswami M (2013) Internet of things (IoT): a vision, architectural elements, and future directions. Futur Gener Comput Syst 29(7):1645–1660Haines W, Gervasio M, Spaulding A, Peintner B (2010) Recommendations for end-user development. In ACM Workshop on User-Centric Evaluation of Recommender Systems and their Interfaces, Barcelona, Spain, pp. 42-49Häkkilä J, Korpipää P, Ronkainen S, Tuomela U (2005) Interaction and end-user programming with a context-aware mobile application. In: Human-computer interaction-INTERACT 2005. Springer, Berlin, pp. 927–937ICIS (2015) Internet Computing in the Internet of Services. Summer School. Department of Informatics Engineering of the University of Coimbra. Available at: http://icis.uc.pt/ . Last time accessed: December 2015Ifttt (2015) Ifttt, If This Then That. Accesible at: https://ifttt.com/ . Last time accessed: December 2015Larman C, Basili VR (2003) Iterative and incremental development: a brief history. Computer 6:47–56Lewis JR (1995) IBM computer usability satisfaction questionnaires: psychometric evaluation and instructions for use. Int J Hum Comput Interact 7(1):57–78Liberman H, Paternò F, Klann M, Wulf V (2006) End user development. In: Liberman H, Paternò F, Wulf V (eds) End-user development: an emerging paradigm, vol 9, pp. 427–457Locale (2015) Accesible at: http://www.twofortyfouram.com . Last time accessed: December 2015Lucci G, Paternò F (2014) Understanding end-user development of context-dependent applications in smartphones. In: Human-centered software engineering. Springer, Berlin, pp. 182–198Mansanet I, Torres V, Valderas P, Pelechano V (2014) A Mobile End-Use Tool for service Compositions. X Jornadas de Ciencia e Ingeniería de Servicios (JCIS 2014), 25–35Mansanet I, Torres V, Valderas P, Pelechano V (2015) IoT Compositions by and for the Crowd. XI Jornadas de Ciencia e Ingeniería de Servicios (JCIS 2015)Neil T (2014) Mobile design pattern gallery: UI patterns for smartphone apps. “O’Reilly Media, Inc.”, SebastopolNielsen J (2005) Ten usability heuristics. https://www.nngroup.com/articles/ten-usability-heuristics . Last time accessed: February 2016Renger M, Kolfschoten GL, de Vreede GJ (2008) Challenges in collaborative modeling: A literature review. In Advances in enterprise engineering I, held at CAiSE 2008, Montpellier, 10. 61–77Repenning A, Ioannidou A (2006) What makes end-user development tick? 13 design guidelines. End user development, Human-Computer Interaction Series, vol 9, pp. 51–85Runeson P, Höst M (2009) Guidelines for conducting and reporting case study research in software engineering. Empir Softw Eng 14(2):131–164Segal J (2005) Two principles of end-user software engineering research, In ACM SIGSOFT software engineering notes (Vol. 30, No. 4, pp. 1–5). ACM, New YorkSerral E, Valderas P, Pelechano V (2013) Context-adaptive coordination of pervasive services by interpreting models during runtime†. Comput J 56(1):87–114Tasker (2015) Tasker, Total Automation for Android. Accesible at: http://tasker.dinglisch.net/ . Last time accessed: December 2015.Uden L, Valderas P, Pastor O (2008) An activity-theory-based model to analyse Web application requirements. Inf Res 13(2):1Valderas P, Pelechano V, Pastor O (2006) A transformational approach to produce web application prototypes from a web requirements model. Int J Web Eng Technol 3(1):4–42Van Deursen A, Klint P, Visser J (2000) Domain-specific languages: an annotated bibliography. Sigplan Notices 35(6):26–36Van Welie M, Trætteberg H (2000) Interaction patterns in user interfaces. In 7th. Pattern Languages of Programs Conference (pp. 13–16)Weber B, Reichert M, Rinderle S (2008) Change patterns and change support features - enhancing flexibility in process-aware information systems. Data Knowl Eng 66:438–466Yu J, Sheng QZ, Han J, Wu Y, Liu C (2012) A semantically enhanced service repository for user-centric service discovery and management. Data Knowl Eng 72:202–21

A Neurocomputational Model of Stimulus-Specific Adaptation to Oddball and Markov Sequences

Stimulus-specific adaptation (SSA) occurs when the spike rate of a neuron decreases with repetitions of the same stimulus, but recovers when a different stimulus is presented. It has been suggested that SSA in single auditory neurons may provide information to change detection mechanisms evident at other scales (e.g., mismatch negativity in the event related potential), and participate in the control of attention and the formation of auditory streams. This article presents a spiking-neuron model that accounts for SSA in terms of the convergence of depressing synapses that convey feature-specific inputs. The model is anatomically plausible, comprising just a few homogeneously connected populations, and does not require organised feature maps. The model is calibrated to match the SSA measured in the cortex of the awake rat, as reported in one study. The effect of frequency separation, deviant probability, repetition rate and duration upon SSA are investigated. With the same parameter set, the model generates responses consistent with a wide range of published data obtained in other auditory regions using other stimulus configurations, such as block, sequential and random stimuli. A new stimulus paradigm is introduced, which generalises the oddball concept to Markov chains, allowing the experimenter to vary the tone probabilities and the rate of switching independently. The model predicts greater SSA for higher rates of switching. Finally, the issue of whether rarity or novelty elicits SSA is addressed by comparing the responses of the model to deviants in the context of a sequence of a single standard or many standards. The results support the view that synaptic adaptation alone can explain almost all aspects of SSA reported to date, including its purported novelty component, and that non-trivial networks of depressing synapses can intensify this novelty response

A dressed bag model study of the final-state NΔN\Delta interaction in photoproduction processes off the deuteron

The impact of the short-range $N\Delta$ interaction on the pion photoproduction processes off the deuteron in the $\Delta$-resonance region is studied in the framework of recently proposed dressed-bag model. A common dressing procedure for bare three- and six-quark states is used to describe both the pion decay widths of baryon resonances and the effective $NN$ (or $N\Delta$) interaction at short ranges related to the inner dressed-bag states. It is shown that the effect of short-range $N\Delta$ interaction for the forward-angle $\pi^\mathrm{o}$ photoproduction off the deuteron cannot be neglected. The prospects for further development of the model to describe the short-range $NN$ (or $N\Delta$) correlations in the lightest nuclei are discussed

EZH2 promotes a bi-lineage identity in basal-like breast cancer cells

The mechanisms regulating breast cancer differentiation state are poorly understood. Of particular interest are molecular regulators controlling the highly aggressive and poorly differentiated traits of basal-like breast carcinomas. Here we show that the Polycomb factor EZH2 maintains the differentiation state of basal-like breast cancer cells, and promotes the expression of progenitor-associated and basal-lineage genes. Specifically, EZH2 regulates the composition of basal-like breast cancer cell populations by promoting a ‘bi-lineage’ differentiation state, in which cells co-express basal- and luminal-lineage markers. We show that human basal-like breast cancers contain a subpopulation of bi-lineage cells, and that EZH2-deficient cells give rise to tumors with a decreased proportion of such cells. Bi-lineage cells express genes that are active in normal luminal progenitors, and possess increased colony-formation capacity, consistent with a primitive differentiation state. We found that GATA3, a driver of luminal differentiation, performs a function opposite to EZH2, acting to suppress bi-lineage identity and luminal-progenitor gene expression. GATA3 levels increase upon EZH2 silencing, mediating a decrease in bi-lineage cell numbers. Our findings reveal a novel role for EZH2 in controlling basal-like breast cancer differentiation state and intra-tumoral cell composition

Temporal Coordination of Gene Networks by Zelda in the Early Drosophila Embryo

In past years, much attention has focused on the gene networks that regulate early developmental processes, but less attention has been paid to how multiple networks and processes are temporally coordinated. Recently the discovery of the transcriptional activator Zelda (Zld), which binds to CAGGTAG and related sequences present in the enhancers of many early-activated genes in Drosophila, hinted at a mechanism for how batteries of genes could be simultaneously activated. Here we use genome-wide binding and expression assays to identify Zld target genes in the early embryo with the goal of unraveling the gene circuitry regulated by Zld. We found that Zld binds to genes involved in early developmental processes such as cellularization, sex determination, neurogenesis, and pattern formation. In the absence of Zld, many target genes failed to be activated, while others, particularly the patterning genes, exhibited delayed transcriptional activation, some of which also showed weak and/or sporadic expression. These effects disrupted the normal sequence of patterning-gene interactions and resulted in highly altered spatial expression patterns, demonstrating the significance of a timing mechanism in early development. In addition, we observed prevalent overlap between Zld-bound regions and genomic “hotspot” regions, which are bound by many developmental transcription factors, especially the patterning factors. This, along with the finding that the most over-represented motif in hotspots, CAGGTA, is the Zld binding site, implicates Zld in promoting hotspot formation. We propose that Zld promotes timely and robust transcriptional activation of early-gene networks so that developmental events are coordinated and cell fates are established properly in the cellular blastoderm embryo

Genetic Background of Prop1df Mutants Provides Remarkable Protection Against Hypothyroidism-Induced Hearing Impairment

Hypothyroidism is a cause of genetic and environmentally induced deafness. The sensitivity of cochlear development and function to thyroid hormone (TH) mandates understanding TH action in this sensory organ. Prop1df and Pou1f1dw mutant mice carry mutations in different pituitary transcription factors, each resulting in pituitary thyrotropin deficiency. Despite the same lack of detectable serum TH, these mutants have very different hearing abilities: Prop1df mutants are mildly affected, while Pou1f1dw mutants are completely deaf. Genetic studies show that this difference is attributable to the genetic backgrounds. Using embryo transfer, we discovered that factors intrinsic to the fetus are the major contributor to this difference, not maternal effects. We analyzed Prop1df mutants to identify processes in cochlear development that are disrupted in other hypothyroid animal models but protected in Prop1df mutants by the genetic background. The development of outer hair cell (OHC) function is delayed, but Prestin and KCNQ4 immunostaining appear normal in mature Prop1df mutants. The endocochlear potential and KCNJ10 immunostaining in the stria vascularis are indistinguishable from wild type, and no differences in neurofilament or synaptophysin staining are evident in Prop1df mutants. The synaptic vesicle protein otoferlin normally shifts expression from OHC to IHC as temporary afferent fibers beneath the OHC regress postnatally. Prop1df mutants exhibit persistent, abnormal expression of otoferlin in apical OHC, suggesting delayed maturation of synaptic function. Thus, the genetic background of Prop1df mutants is remarkably protective for most functions affected in other hypothyroid mice. The Prop1df mutant is an attractive model for identifying the genes that protect against deafness