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Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling.
Organisms respond to tissue damage through the upregulation of protective responses which restore tissue structure and metabolic function. Mitochondria are key sources of intracellular oxidative metabolic signals that maintain cellular homeostasis. Here we report that tissue and cellular wounding triggers rapid and reversible mitochondrial fragmentation. Elevated mitochondrial fragmentation either in fzo-1 fusion-defective mutants or after acute drug treatment accelerates actin-based wound closure. Wounding triggered mitochondrial fragmentation is independent of the GTPase DRP-1 but acts via the mitochondrial Rho GTPase MIRO-1 and cytosolic Ca2+. The fragmented mitochondria and accelerated wound closure of fzo-1 mutants are dependent on MIRO-1 function. Genetic and transcriptomic analyzes show that enhanced mitochondrial fragmentation accelerates wound closure via the upregulation of mtROS and Cytochrome P450. Our results reveal how mitochondrial dynamics respond to cellular and tissue injury and promote tissue repair
Optimal transfer of an unknown state via a bipartite operation
A fundamental task in quantum information science is to transfer an unknown
state from particle to particle (often in remote space locations) by
using a bipartite quantum operation . We suggest the power of
for quantum state transfer (QST) to be the maximal average
probability of QST over the initial states of particle and the
identifications of the state vectors between and . We find the QST power
of a bipartite quantum operations satisfies four desired properties between two
-dimensional Hilbert spaces. When and are qubits, the analytical
expressions of the QST power is given. In particular, we obtain the exact
results of the QST power for a general two-qubit unitary transformation.Comment: 6 pages, 1 figur
Localization of Macroscopic Object Induced by the Factorization of Internal Adiabatic Motion
To account for the phenomenon of quantum decoherence of a macroscopic object,
such as the localization and disappearance of interference, we invoke the
adiabatic quantum entanglement between its collective states(such as that of
the center-of-mass (C.M)) and its inner states based on our recent
investigation. Under the adiabatic limit that motion of C.M dose not excite the
transition of inner states, it is shown that the wave function of the
macroscopic object can be written as an entangled state with correlation
between adiabatic inner states and quasi-classical motion configurations of the
C.M. Since the adiabatic inner states are factorized with respect to each parts
composing the macroscopic object, this adiabatic separation can induce the
quantum decoherence. This observation thus provides us with a possible solution
to the Schroedinger cat paradoxComment: Revtex4,23 pages,1figur
Magneto-Optical Stern-Gerlach Effect in Atomic Ensemble
We study the birefringence of the quantized polarized light in a
magneto-optically manipulated atomic ensemble as a generalized Stern-Gerlach
Effect of light. To explain this engineered birefringence microscopically, we
derive an effective Shr\"odinger equation for the spatial motion of two
orthogonally polarized components, which behave as a spin with an effective
magnetic moment leading to a Stern-Gerlach split in an nonuniform magnetic
field. We show that electromagnetic induced transparency (EIT) mechanism can
enhance the magneto-optical Stern-Gerlach effect of light in the presence of a
control field with a transverse spatial profile and a inhomogeneous magnetic
field.Comment: 7 pages, 5 figure
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