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Total Synthesis of (−)-Sessilifoliamide J
An efficient synthesis of the <i>Stemona</i> alkaloid
(−)-sessilifoliamide J (<b>1</b>) in 12 steps and 7.7%
overall yield from the known building block <b>8</b> is presented.
The synthesis features the Corey lactonization reaction and a highly
diastereoselective α-methylation reaction to build the spiro-lactone
moiety