A Novel and General Method for the Formation of S-Aryl, Se-Aryl, and Te-Aryl Phosphorochalcogenoates

A new and general method for the synthesis of S-, Se-, and Te-aryl phosphorochalcogenoates (chalcogenophosphates) has been developed. S-P, Se-P, and Te-P bonds were formed by the coupling of readily available dialkyl phosphites with diaryl dichalcogenides at 30 degrees C in dimethyl sulfoxide in the presence of catalytic amounts of copper iodide and diethylamine. The reaction proceeded smoothly without exclusion of moisture or air.Major Program of National Natural Science Foundation of China [20732004, J0630429]; Projects of International Cooperation of the Ministry of Science and Technology of the Peoples Republic of China [2006DFA43030

Methyl 2-[2-(tert-but­oxy­carbonyl­amino)-1,3-benzothia­zole-6-carboxamido]­acetate

In the title compound, C16H19N3O5S, the dihedral angle between the benzene ring and the carbonyl­amino group is 18.18 (2)°. In the crystal, mol­ecules form centrosymmetric dimers via pairs of N—H⋯N hydrogen bonds. The dimers are connected via N—H⋯O hydrogen bonds into a three-dimensional network.

Model independent analysis of top quark forward-backward asymmetry at the Tevatron up to \mathcal{O}(\as^2/\Lambda^2)

We present the complete calculations of the forward-backward asymmetry ($A_{\rm FB}$) and the total cross section of top quark pair production induced by dimension-six four quark operators at the Tevatron up to \mathcal{O}(\as^2/\Lambda^2). Our results show that next-to-leading order (NLO) QCD corrections can change $A_{\rm FB}$ and the total cross section by about 10%. Moreover, NLO QCD corrections reduce the dependence of $A_{\rm FB}$ and total cross section on the renormalization and factorization scales significantly. We also evaluate the total cross section and the charge asymmetry ($A_{\rm C}$) induced by these operators at the Large Hadron Collider (LHC) up to \mathcal{O}(\as^2/\Lambda^2), for the parameter space allowed by the Tevatron data. We find that the value of $A_{\rm C}$ induced by these operators is much larger than SM prediction, and LHC has potential to discover these NP effects when the measurement precision increases.Comment: 25 pages, 10 figures; final version in PR

Case report: A novel WASHC5 variant altering mRNA splicing causes spastic paraplegia in a patient

Background: Hereditary spastic paraplegia (HSP) is a progressive upper-motor neurodegenerative disease. Mutations in the WASHC5 gene are associated with autosomal dominant HSP, spastic paraplegia 8 (SPG8). However, due to the small number of reported cases, the exact mechanism remains unclear.Method: We report a Chinese family with HSP. The proband was referred to our hospital due to restless leg syndrome and insomnia. The preliminary clinical diagnosis of the proband was spastic paraplegia. Whole-exome sequencing (WES) and RNA splicing analysis were conducted to evaluate the genetic cause of the disease in this family.Results: A novel splice-altering variant (c.712–2A>G) in the WASHC5 gene was detected and further verified by RNA splicing analysis and Sanger sequencing. Real-time qPCR analysis showed that the expression of genes involved in the Wiskott–Aldrich syndrome protein and SCAR homolog (WASH) complex and endosomal and lysosomal systems was altered due to this variant.Conclusion: A novel heterozygous splice-altering variant (c.712–2A>G) in the WASHC5 gene was detected in a Chinese family with HSP. Our study provided data for genetic counseling to this family and offered evidence that this splicing variant in the WASHC5 gene is significant in causing HSP