6,356 research outputs found

    Gene Therapy Using RNAi

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    Personalized Audio Quality Preference Prediction

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    This paper proposes to use both audio input and subject information to predict the personalized preference of two audio segments with the same content in different qualities. A siamese network is used to compare the inputs and predict the preference. Several different structures for each side of the siamese network are investigated, and an LDNet with PANNs' CNN6 as the encoder and a multi-layer perceptron block as the decoder outperforms a baseline model using only audio input the most, where the overall accuracy grows from 77.56% to 78.04%. Experimental results also show that using all the subject information, including age, gender, and the specifications of headphones or earphones, is more effective than using only a part of them

    Evaluating Stability of Aqueous Multiwalled Carbon Nanotube Nanofluids by Using Different Stabilizers

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    The 0.5 wt.% multiwalled carbon nanotubes/water nanofluids (MWNFs) were produced by using a two-step synthetic method with different types and concentrations of stabilizers. The static position method, centrifugal sedimentation method, zeta potential measurements, and rheological experiments were used to assess the stability of the MWNFs and to determine the optimal type and fixed MWCNTs-stabilizer concentration of stabilizer. Finally, MWNFs with different concentrations of MWCNTs were produced using the optimal type and fixed concentration ratio of stabilizer, and their stability, thermal conductivity, and pH were measured to assess the feasibility of using them in heat transfer applications. MWNFs containing SDS and SDBS with MWCNTs-stabilizer concentration ratio were 5 : 2 and 5 : 4, respectively, showed excellent stability when they were evaluated by static position, centrifugal sedimentation, zeta potential, and rheological experiments at the same time. The thermal conductivity of the MWNFs indicated that the most suitable dispersing MWNF contained SDBS. MWNFs with MWCNTs concentrations of 0.25, 0.5, and 1.0 wt.% were fabricated using an aqueous SDBS solution. In addition, the thermal conductivity of the MWNFs was found to have increased, and the thermal conductivity values were greater than that of water at 25°C by 3.20%, 8.46%, and 12.49%

    r-Hint: A message-efficient random access response for mMTC in 5G networks

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    Massive Machine Type Communication (mMTC) has attracted increasing attention due to the explosive growth of IoT devices. Random Access (RA) for a large number of mMTC devices is especially difficult since the high signaling overhead between User Equipments (UEs) and an eNB may overwhelm the available spectrum resources. To address this issue, we propose “respond by hint” (r-Hint), an ID-free handshaking protocol for contention-based RA in mMTC. The core idea of r-Hint is to avoid sequentially notifying contending UEs of their IDs by broadcasting a hint in the RA Response (RAR). To do so, we exploit the concept of prime factorization and hashing to encode the hint such that UEs can extract their required information accordingly. Our simulation results show that r-Hint reduces the RAR message size by 20%–40%. Such reduction can be translated to around 50% improvement of spectrum efficiency in LTE-M

    DeWave: Discrete EEG Waves Encoding for Brain Dynamics to Text Translation

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    The translation of brain dynamics into natural language is pivotal for brain-computer interfaces (BCIs), a field that has seen substantial growth in recent years. With the swift advancement of large language models, such as ChatGPT, the need to bridge the gap between the brain and languages becomes increasingly pressing. Current methods, however, require eye-tracking fixations or event markers to segment brain dynamics into word-level features, which can restrict the practical application of these systems. These event markers may not be readily available or could be challenging to acquire during real-time inference, and the sequence of eye fixations may not align with the order of spoken words. To tackle these issues, we introduce a novel framework, DeWave, that integrates discrete encoding sequences into open-vocabulary EEG-to-text translation tasks. DeWave uses a quantized variational encoder to derive discrete codex encoding and align it with pre-trained language models. This discrete codex representation brings forth two advantages: 1) it alleviates the order mismatch between eye fixations and spoken words by introducing text-EEG contrastive alignment training, and 2) it minimizes the interference caused by individual differences in EEG waves through an invariant discrete codex. Our model surpasses the previous baseline (40.1 and 31.7) by 3.06% and 6.34%, respectively, achieving 41.35 BLEU-1 and 33.71 Rouge-F on the ZuCo Dataset. Furthermore, this work is the first to facilitate the translation of entire EEG signal periods without needing word-level order markers (e.g., eye fixations), scoring 20.5 BLEU-1 and 29.5 Rouge-1 on the ZuCo Dataset, respectively. Codes and the final paper will be public soon

    Polymorphisms of the _ENPP1_ gene are not associated with type 2 diabetes or obesity in the Chinese Han population

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    *Objective:* Type 2 Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia and with a major feature of insulin resistance. Genetic association studies have suggested that _ENPP1_ might play a potential role in susceptibility to type 2 diabetes and obesity. Our study aimed to examine the association between _ENPP1_ and type 2 diabetes and obesity.

*Design:* Association study between two SNPs, rs1044498 (K121Q) and rs7754561 of ENPP1 and diabetes and obesity in the Chinese Han population.

*Subjects:* 1912 unrelated patients (785 male and 1127 female with a mean age 63.8 ± 9 years), 236 IFG/IGT subjects (83 male and 153 female with a mean age 64 ± 9 years) and 2041 controls (635 male and 1406 female with a mean age 58 ± 9 years).
 
*Measurements:* Subjects were genotyped for two SNPs using TaqMan technology on an ABI7900 system and tested by regression analysis.

*Results:* By logistic regression analysis, rs1044498 (K121Q) and rs7754561 showed no statistical association with type 2 diabetes, obesity under additive, dominant and recessive models either before or after adjusting for sex and age. Haplotype analysis found a marginal association of haplotype C-G (p=0.05) which was reported in the previous study.

*Conclusion:* Our investigation did not replicated the positive association found previously and suggested that the polymorphisms of _ENPP1_ might not play a major role in the susceptibility to type 2 diabetes or obesity in the Chinese Han population

    Pleiotropic Associations of RARRES2

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    Identification of SNP barcode biomarkers for genes associated with facial emotion perception using particle swarm optimization algorithm

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    BACKGROUND: Facial emotion perception (FEP) can affect social function. We previously reported that parts of five tested single-nucleotide polymorphisms (SNPs) in the MET and AKT1 genes may individually affect FEP performance. However, the effects of SNP-SNP interactions on FEP performance remain unclear. METHODS: This study compared patients with high and low FEP performances (n = 89 and 93, respectively). A particle swarm optimization (PSO) algorithm was used to identify the best SNP barcodes (i.e., the SNP combinations and genotypes that revealed the largest differences between the high and low FEP groups). RESULTS: The analyses of individual SNPs showed no significant differences between the high and low FEP groups. However, comparisons of multiple SNP-SNP interactions involving different combinations of two to five SNPs showed that the best PSO-generated SNP barcodes were significantly associated with high FEP score. The analyses of the joint effects of the best SNP barcodes for two to five interacting SNPs also showed that the best SNP barcodes had significantly higher odds ratios (2.119 to 3.138; P < 0.05) compared to other SNP barcodes. In conclusion, the proposed PSO algorithm effectively identifies the best SNP barcodes that have the strongest associations with FEP performance. CONCLUSIONS: This study also proposes a computational methodology for analyzing complex SNP-SNP interactions in social cognition domains such as recognition of facial emotion
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