Trifunctional Fe₃O₄/CaP/Alginate Core–Shell–Corona Nanoparticles for Magnetically Guided, pH-Responsive, and Chemically Targeted Chemotherapy

Chemotherapy of bladder cancer has limited efficacy because of the short retention time of drugs in the bladder during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting of iron oxide (Fe₃O₄) as the core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) as the shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate as the corona for cell targeting (with the composite denoted as RGD-Fe₃O₄/CaP/Alg NPs). We have optimized the reaction conditions to obtain RGD-Fe₃O₄/CaP/Alg NPs with high biocompatibility and suitable particle size, surface functionality, and drug loading/release behavior. The results indicate that the RGD-Fe₃O₄/CaP/Alg NPs exhibit enhanced chemotherapy efficacy toward T24 bladder cancer cells, owing to successful magnetic guidance, pH-responsive release, and improved cellular uptake, which give these NPs great potential as therapeutic agents for future in vivo drug delivery systems

Mesoporous TiO₂ Embedded with a Uniform Distribution of CuO Exhibit Enhanced Charge Separation and Photocatalytic Efficiency

Mixed metal oxide nanoparticles have interesting physical and chemical properties, but synthesizing them with colloidal methods is still challenging and often results in very heterogeneous structures. Here, we describe a simple method to synthesize mesoporous titania nanoparticles implanted with a uniform distribution of copper oxide nanocrystals (CuO@MTs). By calcining a titanium-based metal–organic framework (MIL-125) in the presence of Cu ions, we can trap the Cu in the TiO₂ matrix. Removal of the organic ligand creates mesoporosity and limits phase separation so that tiny CuO nanocrystals form in the interstices of the TiO₂. The CuO@MTs exhibits superior performance for photocatalytic hydrogen evolution (4760 μmol h^–1) that is >90 times larger than pristine titania