XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium.

PurposeEpidemiological evidence suggests that UV irradiation plays an important role in pterygium pathogenesis. UV irradiation can produce a wide range of DNA damage. The base excision repair (BER) pathway is considered the most important pathway involved in the repair of radiation-induced DNA damage. Based on previous studies, single-nucleotide polymorphisms (SNPs) in 8-oxoguanine glycosylase-1 (OGG1), X-ray repair cross-complementing-1 (XRCC1), and AP-endonuclease-1 (APE1) genes in the BER pathway have been found to affect the individual sensitivity to radiation exposure and induction of DNA damage. Therefore, we hypothesize that the genetic polymorphisms of these repair genes increase the risk of pterygium.MethodsXRCC1, APE1, and hOGG1 polymorphisms were studied using fluorescence-labeled Taq Man probes on 83 pterygial specimens and 206 normal controls.ResultsThere was a significant difference between the case and control groups in the XRCC1 genotype (p=0.038) but not in hOGG1 (p=0.383) and APE1 (p=0.898). The odds ratio of the XRCC1 A/G polymorphism was 2.592 (95% CI=1.225-5.484, p=0.013) and the G/G polymorphism was 1.212 (95% CI=0.914-1.607), compared to the A/A wild-type genotype. Moreover, individuals who carried at least one C-allele (A/G and G/G) had a 1.710 fold increased risk of developing pterygium compared to those who carried the A/A wild type genotype (OR=1.710; 95% CI: 1.015-2.882, p=0.044). The hOGG1 and APE1 polymorphisms did not have an increased odds ratio compared with the wild type.ConclusionsXRCC1 (Arg399 Glu) is correlated with pterygium and might become a potential marker for the prediction of pterygium susceptibility

ANALYSIS OF TRUNK ROTATION PATTERNS WHEN SWINGING AT DIFFERENT SPEEDS: A PILOT STUDY

As the trunk plays a vital role during the golf full swing, it is important to understand how body movements affect the golf swing. The purpose of this study was to determine how golfers increase club head speed through trunk rotation. Trunk rotation patterns were captured by 3D motion capture system at 250 Hz. To investigate the effective factors of increasing club head speed, we compared two situations, swing at normal club head speed and at accelerated club head speed, via the trunk rotation angles at three dimensions through six temporary events. The results showed that subtle differences between normal club head speed and accelerated club head speed. To increase club head speed, golfers might optimize the separation between shoulder and pelvic in the early downswing

A TIME SERIOUS ANALYSIS OF THE DYNAMIC INFLUENCE OF FEMALE'S MENSTRUAL CYCLE TO SPORT PERFORMANCE

This research uses Cross Correlation Function, C.C.F., as a dynamic relationship evaluation model to study the dynamic influences of the menstrual cycle on sport performances. This research takes females with a regular menstrual cycle to be the test subjects. Their basic body temperatures were recorded every day. A Kistler Quattro Jump force plate was used to record continuously for sixty days the parameters of muscular strength, jump performance, and fatigue index during the subjects performance of a counter-movement Jump (CMJ), squat Jump (SJ), and thirty-second continuous bent leg jumps (CJB). The late stage of the follicular phase and the early stage of the luteal phase have a positive influence on sport performance. This also illustrates that sport performance for female athletes will be varied dynamically in accordance with the time of menstrual cycle

Outcome after endovascular stent graft treatment for mycotic aortic aneurysm: A systematic review

BackgroundSurgical treatment for mycotic aortic aneurysms is not optimal. Even with a large excision, extensive debridement, in situ or extra-anatomical reconstruction, and with or without lifelong antibiotic treatment, mycotic aneurysms still carry very high mortality and morbidity. The use of endovascular aneurysm repair (EVAR) for mycotic aortic aneurysms simplifies the procedure and provides a good alternative for this critical condition. However, the question remains: if EVAR is placed in an infected bed, what is the outcome of the infection? Does it heal, become aggravated, or even cause a disastrous aortic rupture? In this study, we tried to clarify the risk factors for such an adverse response.MethodsA literature review was undertaken by using MEDLINE. All relevant reports on endoluminal management of mycotic aortic aneurysms were included. Logistic regressions were applied to identify predictors of persistent infection.ResultsA total of 48 cases from 22 reports were included. The life-table analysis showed that the 30-day survival rate was 89.6% ± 4.4%, and the 2-year survival rate was 82.2% ± 5.8%. By univariate analysis, age 65 years or older, rupture of the aneurysm (including those with aortoenteric fistula and aortobronchial fistula), and fever at the time of operation were identified as significant predictors of persistent infection, and preoperative use of antibiotics for longer than 1 week and an adjunct procedure combined with EVAR were identified as significant protective factors for persistent infection. However, by multivariate logistic regression analysis, the only significant independent predictors identified were rupture of aneurysm and fever.ConclusionsEVAR seems a possible alternative method for treating mycotic aortic aneurysms. Identification of the risk factors for persistent infection may help to decrease surgical morbidity and mortality. EVAR could be used as a temporary measure; however, a definite surgical treatment should be considered for patients present with aneurysm rupture or fever

Keyword Join: Realizing Keyword Search in P2P-based Database Systems

In this paper, we present a P2P-based database sharing system that provides information sharing capabilities through keyword-based search techniques. Our system requires neither a global schema nor schema mappings between different databases, and our keyword-based search algorithms are robust in the presence of frequent changes in the content and membership of peers. To facilitate data integration, we introduce keyword join operator to combine partial answers containing different keywords into complete answers. We also present an efficient algorithm that optimize the keyword join operations for partial answer integration. Our experimental study on both real and synthetic datasets demonstrates the effectiveness of our algorithms, and the efficiency of the proposed query processing strategies.Singapore-MIT Alliance (SMA

Keyword Join: Realizing Keyword Search for Information Integration

Information integration has been widely addressed over the last several decades. However, it is far from solved due to the complexity of resolving schema and data heterogeneities. In this paper, we propose out attempt to alleviate such difficulty by realizing keyword search functionality for integrating information from heterogeneous databases. Our solution does not require predefined global schema or any mappings between databases. Rather, it relies on an operator called keyword join to take a set of lists of partial answers from different data sources as input, and output a list of results that are joined by the tuples from input lists based on predefined similarity measures as integrated results. Our system allows source databases remain autonomous and the system to be dynamic and extensible. We have tested our system with real dataset and benchmark, which shows that our proposed method is practical and effective.Singapore-MIT Alliance (SMA

PHYSIOLOGICAL AND ELECTROMYOGRAPHIC RESPONSES AT THREE LEVELS OF BICYCLE SEAT HEIGHT

Recently, bicycle riding has become one of the most popular exercises. As the use time increased, the risk of pedalling injury raised. Holmes (1994) indicated that inappropriate bicycle saddle height could result in lower limbs injuries. The motivation of this study was to find out the best riding position that could effectively use energy from the physiology and electromyography measures. The oxygen consumption (VO2), heart rate (HR), respiratory exchange ratio (RER) and the muscle activity (electromyography, EMG) from rectus femoris (RF) and biceps femoris (BF) of lower limb were collected during a 6 min cycling trail in three different heights of bicycle saddle. The purpose of this study was to compare the effects of three different types of bicycle seat heights and different perspectives of muscle activity and physiology’s parameters

Bacteroides fragilis aortic arch pseudoaneurysm: case report with review

We present a case of 58-year-old woman with underlying diabetes mellitus, hepatitis C virus-related liver cirrhosis, and total hysterectomy for uterine myoma 11 moths ago, who was diagnosed ruptured aortic arch mycotic pseudoaneurysm after a certain period of survey for her unknown fever cause. After emergent surgery with prosthetic graft interposition, all her blood cultures and tissue cultures revealed pathogen with Bacteroides fragilis. Although mycotic aneurysms have been well described in literatures, an aneurysm infected solely with Bacteroides fragilis is unusual, with only eight similar cases in the literature. Here we reported the only female case with her specific clinical and management course and summarized all reported cases of mycotic aneurysm caused by Bacteroides fragilis to clarify their conditions and treatments, alert the difficulty in diagnosis, and importance of highly suspicious