Comparison of energy, total choline, individual choline-containing compounds and betaine between colorectal cancer cases and controls.

<p>^a Intakes of total choline, individual choline-containing compounds and betaine were adjusted for the daily energy intake using the residual method.</p><p>Wilcoxon rank-sum test comparing the median consumption levels between cases and controls.</p><p>Comparison of energy, total choline, individual choline-containing compounds and betaine between colorectal cancer cases and controls.</p

Odds ratios (ORs) and 95% confidence intervals (95%CIs) of colorectal cancer according to quartiles of choline and betaine intake.

<p>^a Odds ratio was adjusted for age (continuous), sex (men/women), residence (urban/rural), marital status (married/other), education (primary school or blow/secondary school/high school/college or above), income level (<2,000/2,001–5,000/5,001–8,000/>8,001), occupation (white collar worker/blue collar worker/farmer or other), family history of cancer (yes/no), smoking status (current/never or past), passive smoking (yes/no), alcohol drinking (yes/no), degree of physical activity (less active/moderate active/more active), BMI (continuous).</p><p>^b Odds ratio was adjusted for the various above confounders and red meat (continuous), fish (continuous).</p><p>^c Odds ratio was adjusted for the various above confounders and red meat (continuous), fish (continuous), beans (continuous).</p><p>^d Odds ratio was adjusted for the various above confounders in ^b and folate intake (continuous).</p><p>^e Odds ratio was adjusted for the various above confounders in ^c and folate intake (continuous).</p><p>Odds ratios (ORs) and 95% confidence intervals (95%CIs) of colorectal cancer according to quartiles of choline and betaine intake.</p

Top five food sources of total choline, choline-containing compounds, and betaine among control subjects.

<p>Top five food sources of total choline, choline-containing compounds, and betaine among control subjects.</p

Correlation coefficients between energy-adjusted folate, betaine, choline and individual choline-containing compounds in controls (two-tailed Spearman).

<p>** Correlations are significant (<i>p</i><0.01).</p><p>* Correlations are significant (<i>p</i><0.05)</p><p>Correlation coefficients between energy-adjusted folate, betaine, choline and individual choline-containing compounds in controls (two-tailed Spearman).</p

Odds ratios (ORs) and 95% confidence intervals (95%CIs) of colorectal cancer according to quartiles of five main choline-containing compounds intakes.

<p>^a Odds ratio was adjusted for age (continuous), sex (men/women), residence (urban/rural), marital status (married/other), education (primary school or blow/secondary school/high school/college or above), income level (<2,000/2,001–5,000/5,001–8,000/>8,001), occupation (white collar worker/blue collar worker/farmer or other), family history of cancer (yes/no), smoking status (current/never or past), passive smoking (yes/no), alcohol drinking (yes/no), degree of physical activity (less active/moderate active/more active), and BMI (continuous).</p><p>^b Odds ratio was adjusted for the various above confounders and folate intake (continuous).</p><p>Odds ratios (ORs) and 95% confidence intervals (95%CIs) of colorectal cancer according to quartiles of five main choline-containing compounds intakes.</p

ROC curve to determine the IBL cutoff volume.

<p>ROC curve to determine the IBL cutoff volume.</p

Kaplan–Meier curves for overall survival (a) and recurrence free survival (b) after CRLM resection for the entire patient cohort.

<p>The median OS for all patients was 73.2 months, and the proportion of patients alive at 3 and 5 years was 65% and 53%, respectively. The median RFS period was 30.7 months.</p

The survival curves for patients in different time durations (A) and with different tumor locations (B).

<p>The survival curves for patients in different time durations (A) and with different tumor locations (B).</p