DataSheet_1_Brain-gut axis and psychiatric disorders: A perspective from bibliometric and visual analysis.docx

BackgroundThe Brain-Gut Axis, a bidirectional signaling pathway that connects the intestinal and central nervous systems, plays an important role in the development of psychiatric disorders. However, the overall research trends in this field are unclear. This study explored the patterns of research on the brain-gut axis and psychiatric disorders from a bibliometric perspective.MethodsRelevant data were retrieved from the Web of Science Core Collection, with search terms on psychiatric disorders and the brain-gut axis. R (version 4.2.0), VOSviewer (version 1.6.17), CiteSpace software, and the online bibliometric platform were used in the data analysis.ResultsA total of 2,298 articles published between 1993 and 2022 were identified, showing an increasing trend over time. China (1,859; 20.70%) was the country that contributed the most publications. The journal Nutrients (95; 4.13%) published the most publications. Cryan JF (153; H-index=73) and University College Cork (559; 22.54%) were the most influential author and the most productive institution, respectively. The high-frequency keywords were clustered into six themes, including neurodegenerative diseases, stress-related diseases, immune, brain behavior, depression, and probiotic-related topics; of which, depression (880; 2019), anxiety (207; 2018) and autism (191; 2019) were the most studied psychiatric disorders in the past 5 years. “Depressive symptom” (2019-2020) and “probiotic treatment” (2019-2020) were the main areas addressed in recent years.ConclusionResearch on the brain-gut axis and psychiatric disorders has attracted increasing attention in the past decade, with most publications originating from high-income level countries. This study provides a useful perspective on understanding the research trends, key hot topics, and research gaps in this expanding field.</p

Flexible Units Induced Three-Dimensional Covalent Organic Frameworks with a Heteromotif Molecular Junction for Photocatalytic H₂O₂ Production

In recent years, significant progress has been achieved in the field of three-dimensional covalent organic frameworks (3D COFs). However, there is still a great challenge to use flexible building units to synthesize high-connectivity 3D COFs. In this work, we showed that [6 + 3] 3D COFs could be constructed by inducing highly flexible planar building blocks from C3 antitriangular prismed 3D building blocks. Herein, two 3D COFs with spn topology based on flexible cyclotriphosphazene units were constructed and denoted as TAA/TAB-CTP-COF, and their redox ability and photophysical features can be finely regulated by the coupled functional group, such as benzene and triazine groups. As a result, the redox heteromotif molecular junction TAA-CTP-COF with fully exposed active sites achieved high photocatalytic production of hydrogen peroxide (H2O2) with a yield of 1041 μM h–1 without any additional photosensitizers, organic scavengers, or cocatalysts. Furthermore, in the presence of an electron donor, the production rate of H2O2 could reach up to 2221 μM h–1, exhibiting one of the best performances for photocatalytic H2O2 production in the field of crystalline materials. This work showcases the potential of using flexible building blocks in building 3D COFs and highlights the versatility and efficacy of metal-free COFs in solar energy conversion